Paclitaxel Accord
Paclitaxel Accord is a cancer medicine that stops cancer cells from growing.
Form
infuusiokonsentraatti, liuosta varten
Strength
6 mg/ml
Active Ingredient
Paclitaxel
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
Your doctor will determine your specific dose based on your condition.
Method
This medicine is given as a drip into a vein (intravenous infusion) by a healthcare professional.
Important
The infusion usually lasts 3 or 24 hours and is given every 2 or 3 weeks, as directed by your doctor.
Possible Side Effects
COMMON
- •Minor allergic reactions like flushing, rash, itching.
- •Infections, mainly upper respiratory tract infection and urinary tract infection.
- •Shortness of breath.
- •Sore throat or mouth sores, painful and red mouth, diarrhea, feeling sick or being sick (vomiting).
- •Hair loss.
- •Muscle pain, cramps, joint pain.
- •Fever, severe chills, headache, dizziness, tiredness, paleness, bleeding, easier bruising.
- •Numbness, tingling, or weakness in arms and legs (signs of nerve damage).
- •Blood tests may show low platelet count, low red or white blood cell count, low blood pressure.
- •Temporary, mild changes to nails and skin, reactions at the injection site (local swelling, pain, redness).
- •Blood tests may show slower heart rhythm, severely increased liver enzymes.
RARE
- •Low white blood cell count with fever and increased infection risk (febrile neutropenia).
- •Nerve effects causing muscle weakness in arms and legs (motor neuropathy).
- •Shortness of breath, blood clot in the lung, lung scarring, lung inflammation, fluid in the lungs.
- •Bowel blockage, bowel rupture, colon inflammation (ischemic colitis), pancreas inflammation (pancreatitis).
- •Itching, rash, red skin (erythema).
- •Blood poisoning (sepsis), abdominal lining inflammation (peritonitis).
- •Fever, dehydration, weakness, swelling, general feeling of being unwell.
- •Severe, potentially life-threatening allergic reaction (anafylaksia).
- •Blood tests may show increased blood creatinine, a sign of kidney problems.
- •Heart failure.
- •Shock caused by infections (septic shock).
- •Heart palpitations, heart conduction problems, fast heartbeat, heart attack, respiratory distress.
- •Exhaustion, sweating, fainting, significant allergic reactions, vein inflammation caused by blood clot (thrombophlebitis), swelling of face, lips, mouth, tongue, or throat.
- •Back pain, chest pain, pain in hands and feet, chills, abdominal pain (stomach pain).
- •Blood tests may show severe increase in bilirubin (jaundice), high blood pressure, and blood clots.
- •Irregular, fast heartbeat (atrial fibrillation, supraventricular tachycardia).
- •Sudden disorder of blood-forming cells (acute myeloid leukemia, myelodysplastic syndrome).
- •Optic nerve and/or vision problems.
- •Hearing loss or reduction (ototoxicity), ringing in ears (tinnitus), vertigo.
- •Cough.
- •Blood clot in blood vessels of abdomen and bowel (mesenteric thrombosis), colon inflammation sometimes with persistent severe diarrhea (pseudomembranous colitis, neutropenic colitis), fluid in abdomen (ascites), esophagus inflammation, constipation.
- •Severe hypersensitivity reactions including fever, red skin, joint pain and/or eye inflammation (Stevens-Johnson syndrome), localized skin peeling (epidermal necrolysis), redness with irregular red (fluid-filled) spots (erythema multiforme), skin inflammation with blisters and flaking (exfoliative dermatitis), hives, nail detachment (patients under treatment should protect hands and feet from sunlight).
- •Loss of appetite (anorexia).
- •Severe and potentially fatal hypersensitivity reactions with shock (anaphylactic shock).
- •Liver dysfunction (liver necrosis, hepatic encephalopathy, both with reported fatalities).
- •State of confusion.
- •Skin hardening/thickening (scleroderma).
- •Sudden tightening of airway muscles (bronchospasm).
- •Metabolic complications after cancer treatment (tumor lysis syndrome).
- •Eye diseases, such as thickened and swollen macula (macular edema), seeing flashes of light (photopsia), and floating spots, dots, specks, and 'cobwebs' in the field of vision (vitreous floaters).
- •Vein inflammation (phlebitis).
- •Systemic lupus erythematosus.
- •Severe condition causing easy bleeding, easy blood clots, or both (disseminated intravascular coagulation, DIC).
- •Redness and swelling on palms or soles, which may cause skin peeling.
Important Warnings
- Do not use if you are allergic to paclitaxel or any other ingredient, especially polyoxyl 35 castor oil.
- Do not use if you are breastfeeding.
- Do not use if your white blood cell count is too low. Your doctor will check this with blood tests.
- Do not use if you have a severe, uncontrolled infection and are being treated for Kaposi's sarcoma.
- Tell your doctor immediately if you have severe allergic reactions like trouble breathing, chest tightness, dizziness, or skin rash.
Show 9 more warnings
- Tell your doctor immediately if you have fever, severe chills, sore throat, or mouth sores (signs of bone marrow problems).
- Tell your doctor immediately if you feel numbness, tingling, or weakness in your arms or legs (signs of nerve damage). Your dose may need to be lowered.
- Tell your doctor if you have severe liver problems, as this medicine may not be suitable for you.
- Tell your doctor if you have heart rhythm problems.
- Tell your doctor immediately if you develop severe or lasting diarrhea with fever and stomach pain.
- Tell your doctor if you have previously had radiation therapy to the chest, as it may increase the risk of lung inflammation.
- Tell your doctor if you have a sore or red mouth (sign of inflammation) and are being treated for Kaposi's sarcoma. Your dose may need to be lowered.
- This medicine must always be given into a vein. Giving it into an artery can cause pain, swelling, redness, and warmth.
- If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor. You must use effective birth control during treatment and for 6 months after. Do not breastfeed.