Ketipinor
Ketipinor is a medicine containing quetiapine, used to treat mental health conditions like bipolar depression, mania, and schizophrenia.
Form
depottabletti
Strength
200 mg
Active Ingredient
Quetiapine fumarate
Manufacturer
Orion Corporation
How to Use
Dosage
Your doctor will prescribe a starting dose, and the daily dose usually ranges from 150 mg to 800 mg, depending on your condition.
Method
Take tablets once daily, whole with water, without food (at least 1 hour before a meal or at bedtime). Do not split, chew, or crush.
Important
The usual maximum daily dose is 800 mg.
Possible Side Effects
COMMON
- •Dizziness (may lead to falls), headache, dry mouth
- •Drowsiness (may disappear with continued use, may lead to falls)
- •Withdrawal symptoms (e.g., insomnia, nausea, headache, diarrhea, vomiting, dizziness, irritability) if treatment is stopped suddenly.
- •Weight gain
- •Abnormal muscle movements (difficulty starting movements, tremor, restlessness, muscle stiffness without pain)
- •Changes in certain fat levels (triglycerides and total cholesterol)
- •Fast pulse, palpitations, pounding or skipping heartbeat
- •Constipation, indigestion
- •Weakness
- •Swelling of hands or feet
- •Low blood pressure, especially when standing up (may cause dizziness or faintness, leading to falls)
- •High blood sugar
- •Blurred vision
- •Abnormal dreams and nightmares
- •Increased appetite
- •Irritability
- •Speech problems
- •Suicidal thoughts and worsening depression
- •Shortness of breath
- •Vomiting (mainly in the elderly)
- •Fever
- •Changes in thyroid hormone levels in the blood
- •Decrease in certain types of blood cells
- •Increased liver enzymes in the blood
- •Increased prolactin levels in the blood (can cause breast swelling and unexpected milk production in men and women, or missed/irregular periods in women)
RARE
- •Seizures (epileptic fits)
- •Allergic reactions (e.g., hives, swelling of skin around mouth)
- •Unpleasant feeling in the legs (restless legs syndrome)
- •Difficulty swallowing
- •Uncontrolled movements, especially of the face or tongue
- •Sexual dysfunction
- •Diabetes
- •Changes in heart's electrical activity seen on ECG (QT prolongation)
- •Slower than normal heart rate (especially at start of treatment, may be associated with low blood pressure and fainting)
- •Difficulty urinating
- •Fainting (may lead to falls)
- •Stuffy nose
- •Decrease in red blood cell count
- •Decrease in blood sodium levels
- •Worsening of diabetes
- •Confusion
- •Severe reaction with fever, sweating, stiff muscles, extreme drowsiness or weakness (neuroleptic malignant syndrome)
- •Yellowing of skin and eyes (jaundice)
- •Liver inflammation (hepatitis)
- •Prolonged, painful erection (priapism)
- •Breast swelling and unexpected milk production (galactorrhea)
- •Menstrual disorders
- •Blood clots in veins (especially in legs, with swelling, pain, redness), potentially traveling to lungs causing chest pain and breathing difficulties; seek immediate medical help.
- •Sleepwalking, sleep-talking, sleep-eating, or other sleep-related activities
- •Decrease in body temperature (hypothermia)
- •Pancreatitis
- •Metabolic syndrome (combination of belly fat, low 'good' cholesterol, high triglycerides, high blood pressure, and high blood sugar)
- •Fever, flu-like symptoms, sore throat or other infection with very low white blood cell count (agranulocytosis)
- •Bowel obstruction
- •Increased blood levels of creatine phosphokinase (a substance from muscles)
- •Severe rash, blisters, or red patches on the skin
- •Severe allergic reaction (anaphylactic shock), which can cause breathing difficulties or shock
- •Rapid swelling of the skin, usually around the eyes, lips, or throat (angioedema)
- •Severe blistering of the skin, mouth, eyes, or genitals (Stevens-Johnson syndrome)
- •Abnormal secretion of hormone that regulates urine volume
- •Muscle fiber breakdown and muscle pain (rhabdomyolysis)
- •Rash with irregular red patches (erythema multiforme)
- •Red skin areas with small pus-filled blisters (acute generalized exanthematous pustulosis, AGEP)
- •Severe, sudden allergic reaction with fever, skin blisters, and peeling skin (toxic epidermal necrolysis)
- •General allergic reaction (DRESS syndrome) with flu-like symptoms, rash, fever, swollen lymph nodes, and abnormal blood values (e.g., increased eosinophils, liver enzymes)
- •Heart muscle disease (cardiomyopathy)
- •Heart muscle inflammation (myocarditis)
- •Blood vessel inflammation (vasculitis), often with red or purple spots on the skin
- •Withdrawal symptoms in newborns if the mother used Ketipinor during pregnancy
- •Stroke
Important Warnings
- Do not take Ketipinor if you are allergic to quetiapine or any of its ingredients.
- Avoid grapefruit juice. Do not take with certain HIV medicines, antifungal medicines (azoles), erythromycin or clarithromycin (antibiotics), or nefazodone (an antidepressant).
- Contact a doctor immediately if you have thoughts of harming yourself or suicide.
- Seek immediate medical attention if you experience fever, severe muscle stiffness, sweating, or reduced consciousness at the same time (symptoms of neuroleptic malignant syndrome).
- Report uncontrolled movements, especially of the face or tongue, to your doctor.
Show 21 more warnings
- Tell your doctor if you feel dizzy or very sleepy, as this can increase the risk of falls, especially in older patients.
- Inform your doctor about any seizures.
- Report a prolonged, painful erection (priapism) to your doctor.
- Seek urgent cardiac evaluation if you experience a fast and irregular heartbeat, even at rest, palpitations, breathing difficulties, chest pain, or unexplained tiredness.
- Using Ketipinor with antidepressants can cause serotonin syndrome, a serious condition.
- Tell your doctor if you or your family have a history of heart problems.
- Inform your doctor if you have low blood pressure.
- Tell your doctor if you have had a stroke, especially if you are elderly.
- Inform your doctor if you have liver problems.
- Tell your doctor if you have diabetes or a high risk of developing it.
- Inform your doctor if you have a history of low white blood cell count.
- Ketipinor should not be used in elderly patients with dementia due to increased risks.
- Inform your doctor if you are elderly and have Parkinson's disease or parkinsonism.
- Tell your doctor if you or your family have a history of blood clots.
- Tell your doctor if you have sleep apnea or use medicines that slow down brain activity.
- Inform your doctor if you have urinary retention, enlarged prostate, bowel obstruction, or high eye pressure.
- Tell your doctor if you have a history of alcohol or drug abuse.
- Stop taking Ketipinor and contact your doctor immediately if you develop severe skin reactions like blisters, peeling skin, or a rash with fever and swollen glands.
- Weight gain can occur; your doctor will monitor your weight regularly.
- Ketipinor should not be used in children and adolescents under 18 years.
- Do not stop taking Ketipinor suddenly without consulting your doctor, as it can cause withdrawal symptoms like insomnia, nausea, headache, diarrhea, vomiting, dizziness, or irritability.
Use in Elderly Patients
Category D
Avoid use in older adults. Anticholinergic. Sedative. For treatment of psychosis only. Inappropriate as a hypnotic. Increases the risk of cardiovascular events, QT prolongation and orthostatic hypotension. Increases risk of falls, extrapyramidal symptoms and cognitive impairment. Reduces the effectiveness of drugs for Alzheimer’s disease. Avoid grapefruit. (updated 15.1.2024)