Uromitexan
Uromitexan is used to protect your bladder from damage when you are treated with certain cancer medicines (ifosfamide or cyclophosphamide).
Form
injektioneste, liuos
Strength
100 mg/ml
Active Ingredient
Mesna
Manufacturer
Baxter Oy
How to Use
Dosage
Your doctor will decide the correct dose for you, taking into account other cancer medicines you are receiving.
Method
This medicine is given as an injection or drip (infusion) directly into a vein in the hospital. It will always be given by a healthcare professional.
Important
Your doctor will determine the maximum daily dose for you individually.
Possible Side Effects
COMMON
- •Headache
- •Dizziness, feeling faint
- •Drowsiness, lethargy
- •Flushing
- •Abdominal pain, colic
- •Nausea
- •Diarrhea
- •Rash
- •Reactions at the injection/infusion site, such as itching, rash, pain, redness, swelling
- •Fever
- •Flu-like illness
- •Swollen/enlarged lymph nodes (lymphadenopathy)
- •Vomiting
- •Decreased appetite, anorexia
- •Flatulence
- •Constipation
- •Feeling of dehydration
- •Insomnia
- •Nightmares
- •Tingling or numbness of the skin (paresthesia)
- •Increased skin sensitivity (hyperesthesia)
- •Reduced sensation (hypoesthesia)
- •Attention disorder
- •Conjunctivitis (inflammation of the eye lining)
- •Light sensitivity
- •Blurred vision
- •Palpitations (fast or strong heartbeat)
- •Nasal congestion
- •Sharp chest pain when breathing (pleuritic pain)
- •Dry mouth
- •Bronchospasm (muscle cramps in the airways)
- •Shortness of breath
- •Laryngeal discomfort (throat discomfort)
- •Nosebleed (epistaxis)
- •Stiffness
- •Weakness, fatigue
- •Chest pain
- •Malaise (general feeling of being unwell)
- •Redness
- •Cough
- •Pharyngitis (sore throat)
- •Mucous membrane irritation
- •Burning chest pain (substernal/epigastric pain)
- •Gum bleeding
- •Increased liver enzymes in blood (transaminases)
- •Itching (pruritus)
- •Excessive sweating (hyperhidrosis)
- •Joint pain (arthralgia)
- •Back pain
- •Muscle pain (myalgia)
- •Limb pain (arm/leg pain)
- •Jaw pain
- •Painful or difficult urination (dysuria)
RARE
- •Hypersensitivity reactions
- •Severe allergic reaction (anaphylaxis, anaphylactoid reaction)
- •Low counts of all blood cells (red and white blood cells, platelets) in the blood (pancytopenia)
- •Low counts of infection-fighting white blood cells (leukopenia, lymphopenia)
- •Abnormally high amounts of eosinophils (a type of blood cell formed in the bone marrow) in the blood or body tissues (eosinophilia)
- •Low platelet count (thrombocytopenia)
- •Convulsions, seizures
- •Swelling around the eyes (periorbital edema)
- •Changes in ECG (ST segment elevation or other abnormal findings)
- •Fast pulse
- •Circulatory problems
- •Low or high blood pressure
- •Shortness of breath
- •Low oxygen levels in the body (hypoxia, reduced oxygen saturation)
- •Coughing up blood from the lungs or airways (hemoptysis)
- •Mouth inflammation (stomatitis)
- •Bad taste in mouth
- •Liver inflammation (hepatitis)
- •Increased liver enzymes in blood (gamma-glutamyltransferase, alkaline phosphatase)
- •Blistering (vesiculation)
- •Life-threatening condition causing rash, sores, sore throat, conjunctivitis (inflammation of eye lining), and skin peeling (toxic epidermal necrolysis, Stevens-Johnson syndrome)
- •Hives-like swelling (urticarial edema)
- •Itchy, red rash that can develop into sores (erythema multiforme)
- •Skin redness (erythema)
- •Drug rash
- •Sores and/or blisters on the skin and mucous membranes
- •Sudden, localized swelling under the skin or mucous membranes (angioedema)
- •Rash that reappears in the same spot with repeated drug exposure (fixed drug eruption)
- •Photosensitivity rash
- •Hives (urticaria)
- •Burning sensation in the skin
- •Acute kidney failure
- •Asthenia (lack of energy)
- •Mucous membrane reactions
- •Facial swelling (facial edema)
- •Peripheral edema (swelling of limbs due to fluid retention)
- •Increased breathing rate
- •Reactions at the injection site (thrombophlebitis, irritation)
- •Severe blood clotting disorder with increased risk of blood clots in vessels (disseminated intravascular coagulation (DIC))
- •Abnormal laboratory results (e.g., prolonged prothrombin time, prolonged activated partial thromboplastin time)
Important Warnings
- Do not use Uromitexan if you are allergic to mesna or similar medicines (thiols).
- Tell your doctor if you have previously had breathing difficulties, wheezing, skin redness, itching, or swelling after receiving Uromitexan.
- Tell your doctor if you have an autoimmune disease, such as rheumatoid arthritis or systemic lupus erythematosus, as this may increase the risk of side effects.
- Tell your doctor if you have previously had a blockage in your urinary tract that prevents normal urine flow.
- Seek immediate medical attention if you develop swelling of the face, tongue, or throat, difficulty swallowing, hives, or breathing difficulties.
Show 3 more warnings
- If you are taking a blood-thinning medicine (warfarin), tell your doctor, as Uromitexan can increase its effect. Blood clotting values should be monitored regularly.
- If you are pregnant, breastfeeding, or planning to become pregnant, ask your doctor for advice before using Uromitexan.
- This medicine may cause dizziness, drowsiness, or blurred vision, which can affect your ability to drive or operate machinery.