Mitomycin Accord
Mitomycin Accord is a medicine that slows down or stops the growth of cancer cells.
Form
injektio/infuusiokuiva-aine, liuosta varten
Strength
20 mg
Active Ingredient
Mitomycin
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
Your doctor will decide your dose. It can be given into a vein (10-20 mg per square meter of body surface every 6-8 weeks, 8-12 mg per square meter every 3-4 weeks, or 5-10 mg per square meter every 1-6 weeks) or into the bladder (20-40 mg weekly for 8-12 weeks, or 4-10 mg 1-3 times a week).
Method
This medicine is given by a healthcare professional. It is given as an injection or infusion into a vein, or into the bladder after being mixed.
Important
The maximum dose per administration is 20 mg per square meter of body surface (for intravenous) or 40 mg (for intravesical).
Possible Side Effects
COMMON
- •Blood disorders: reduced blood cell production in bone marrow, decreased white blood cells (increasing infection risk), decreased platelets (causing bruising and bleeding).
- •Nausea, vomiting.
- •Lung problems: shortness of breath, dry cough, and wheezing (interstitial pneumonia).
- •Skin rash and irritation.
- •Numbness, swelling, and painful redness in palms and soles (hand-foot syndrome).
- •Kidney problems: kidney failure, kidney damage, increased creatinine levels – kidneys may not work properly.
- •Cellulitis and tissue death (necrosis) due to accidental injection outside the vein.
- •Bladder inflammation (cystitis), possibly with blood in urine or bladder bleeding (after bladder administration).
- •Painful urination, frequent urination, sometimes at night (after bladder administration).
- •Blood in urine (hematuria) (after bladder administration).
- •Local irritation of the bladder wall (after bladder administration).
RARE
- •Inflammation of mucous membranes (mucositis), including mouth lining.
- •Diarrhea.
- •Hair loss (alopecia).
- •Fever.
- •Loss of appetite (anorexia).
- •Life-threatening infection.
- •Blood poisoning (sepsis).
- •Decreased red blood cells, sometimes with acute kidney failure (hemolytic anemia, MAHA syndrome, HUS).
- •Heart failure after previous cancer treatment (anthracyclines).
- •Increased blood pressure in lung vessels, leading to shortness of breath, dizziness, and fainting (pulmonary hypertension).
- •Narrowing of lung veins (pulmonary veno-occlusive disease [PVOD]).
- •Liver disease (liver failure).
- •Increased liver enzyme levels (transaminases).
- •Yellowing of skin and whites of eyes (jaundice).
- •Blockage of liver veins (veno-occlusive liver disease), leading to fluid buildup, enlarged liver, and high bilirubin levels.
- •Widespread rash.
- •Severe allergic reaction (symptoms may include weakness, rash or hives, itching, swelling of lips, face, and airways with breathing difficulties, loss of consciousness).
- •Severe bladder inflammation where parts of the bladder wall may die (allergic cystitis, necrotizing cystitis) (after bladder administration).
- •Narrowing of the ureter (after bladder administration).
- •Decreased bladder capacity (after bladder administration).
- •Hardening of the bladder wall (calcification, fibrosis) (after bladder administration).
Important Warnings
- Do not use if you are allergic to mitomycin or any other ingredients in this medicine.
- Do not use if you are breastfeeding.
- Do not use if you have very low blood cell counts (red, white, or platelets), a tendency to bleed, or an active infection.
- If using in the bladder, do not use if your bladder wall is perforated (has a hole).
- Tell your doctor if you have lung, liver, or kidney problems.
Show 7 more warnings
- Tell your doctor if your general health is poor.
- Tell your doctor if you are receiving radiation therapy or other cancer medicines, as side effects might worsen.
- If you are receiving this medicine in your bladder, tell your doctor if you have bladder inflammation.
- Tell your doctor if you have bone marrow depression (your bone marrow cannot make enough blood cells), as this can worsen and lead to life-threatening infections.
- Women of childbearing age must avoid getting pregnant and use contraception during treatment and for at least 6 months after. Men should also use contraception.
- Do not get vaccinated with live vaccines during treatment, as it increases infection risk.
- This medicine should only be given by healthcare professionals experienced with this type of treatment.