Lenalidomide Sandoz
Lenalidomide Sandoz is a medicine containing lenalidomide that affects the immune system, used to treat multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma, and follicular lymphoma in adults.
Form
kapseli, kova
Strength
7.5 mg
Active Ingredient
Lenalidomide
Manufacturer
Sandoz A/S
How to Use
Dosage
Your doctor will determine your specific dose and treatment schedule, which may be in 21-day or 28-day cycles.
Method
Swallow capsules whole with water, with or without food, at the same time each day as directed by your doctor. Do not break, open, or chew the capsules.
Important
The maximum daily dose is determined and adjusted by your doctor based on your condition and blood test results.
Possible Side Effects
COMMON
- •Decrease in red blood cells (anemia), causing tiredness and weakness.
- •Skin rashes, itching.
- •Muscle cramps, muscle weakness, muscle pain, bone pain, joint pain, back pain, limb pain.
- •Swelling, including swelling in arms and legs.
- •Weakness, tiredness.
- •Fever and flu-like symptoms, including muscle aches, headache, earache, cough, chills.
- •Numbness, tingling or burning sensation, pain in hands or feet, dizziness, tremor.
- •Decreased appetite, altered taste.
- •Increased pain, increased tumor size or redness around the tumor.
- •Weight loss.
- •Constipation, diarrhea, nausea, vomiting, abdominal pain, heartburn.
- •Low potassium or calcium, and/or low sodium in blood.
- •Underactive thyroid gland (hypothyroidism).
- •Leg pain (may be a blood clot symptom), chest pain or shortness of breath (may be lung blood clots).
- •All types of infections, including sinus, lung, and upper respiratory tract infections.
- •Shortness of breath.
- •Blurred vision.
- •Clouding of the eye (cataract).
- •Kidney problems (kidneys not working properly).
- •Abnormal liver function test results.
- •Increased protein in blood that can cause artery swelling (vasculitis).
- •High blood sugar (diabetes).
- •Low blood sugar.
- •Headache.
- •Nosebleeds.
- •Dry skin.
- •Depression, mood changes, difficulty sleeping.
- •Cough.
- •Low blood pressure.
- •General feeling of being unwell.
- •Sore inflamed mouth, dry mouth.
- •Dehydration.
- •Breakdown of red blood cells (hemolytic anemia).
- •Certain types of skin tumors.
- •Bleeding from gums, stomach or intestines.
- •High blood pressure, slow, fast or irregular heartbeat.
- •Increased levels of a substance from normal and abnormal breakdown of red blood cells.
- •Increased levels of a protein indicating inflammation.
- •Darker skin, skin discoloration due to bleeding under the skin (bruising, swelling).
- •Increased uric acid in blood.
- •Skin problems (redness, cracking, flaking, scaling, hives).
- •Increased sweating, night sweats.
- •Difficulty swallowing, sore throat, impaired voice or voice changes.
- •Runny nose.
- •Unusual urine output (too much or too little) or inability to control urine.
- •Blood in urine.
- •Shortness of breath, especially when lying down (may be a symptom of heart failure).
- •Erectile dysfunction.
- •Stroke, fainting, dizziness (inner ear problem), temporary loss of consciousness.
- •Chest pain radiating to arms, neck, jaw, back or stomach, sweating and shortness of breath, nausea or vomiting (may be symptoms of a heart attack).
- •Muscle weakness, lack of energy.
- •Neck pain, chest pain.
- •Chills.
- •Joint swelling.
- •Slow or blocked bile flow from the liver.
- •Low phosphate or magnesium in blood.
- •Difficulty speaking.
- •Liver damage.
- •Balance problems, difficulty moving.
- •Deafness, ringing in ears (tinnitus).
- •Nerve pain, unpleasant or abnormal sensations, especially to touch.
- •Excess iron in body.
- •Thirst.
- •Confusion.
- •Toothache.
- •Falls leading to injuries.
RARE
- •Bleeding inside the skull.
- •Circulatory problems.
- •Vision loss.
- •Loss of libido (sex drive).
- •Large urine output with bone pain and weakness, which may be signs of kidney disease (Fanconi syndrome).
- •Yellowing of skin, mucous membranes or eyes (jaundice), pale stools, dark urine, itchy skin, rash, abdominal pain or swelling (may be signs of liver damage).
- •Abdominal pain, swelling or diarrhea, which may be symptoms of colon inflammation (colitis or appendicitis).
- •Kidney cell damage (renal tubular necrosis).
- •Skin color changes, sensitivity to sunlight.
- •Tumor lysis syndrome (metabolic complications from cancer treatment, possibly including changes in blood chemistry, high potassium, phosphate, uric acid, low calcium, leading to kidney or heart rhythm problems, seizures, and sometimes death).
- •High blood pressure in the blood vessels carrying blood to the lungs (pulmonary hypertension).
- •Sudden or worsening upper abdominal and/or back pain for several days, possibly with nausea, vomiting, fever, and rapid heart rate (may be signs of pancreatitis).
- •Wheezing, shortness of breath, or dry cough (may be signs of lung inflammation).
- •Muscle tissue breakdown (rhabdomyolysis), which can cause kidney problems; some cases occurred when Lenalidomide Sandoz was given with a statin (cholesterol-lowering medicine).
- •Skin disease caused by small blood vessel inflammation (leukocytoclastic vasculitis) with joint pain and fever.
- •Stomach or intestinal wall rupture, leading to severe infection. Report severe abdominal pain, fever, nausea, vomiting, bloody stools or changes in bowel habits.
- •Viral infections, including shingles (painful blistering rash) and recurrence of hepatitis B infection (yellow skin/eyes, dark urine, right-sided abdominal pain, fever, nausea, vomiting).
- •Rejection of transplanted organs (e.g., kidney, heart).
Important Warnings
- Do not take this medicine if you are pregnant, planning to get pregnant, or could get pregnant, as it can cause severe birth defects. You must use effective birth control.
- Stop taking this medicine and get medical help right away if you have a serious allergic reaction, such as hives, rash, swelling of your face or throat, or trouble breathing. Also, report severe skin reactions like widespread rash with skin peeling or blistering.
- Tell your doctor immediately if you have signs of a serious infection (fever, chills, sore throat, cough, mouth sores) or if you bleed or bruise easily without injury. Also, report any new chest pain, leg pain (which could mean a blood clot), or sudden shortness of breath.
- Consult your doctor if you experience bone pain, muscle weakness, confusion, or unusual tiredness, as these could be signs of high calcium levels in your blood.
- Report any blurred vision, speech problems, weakness in your arms or legs, balance issues, numbness, memory loss, or confusion to your doctor, as these may indicate a rare but serious brain condition called PML.
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- Inform your doctor if you have new or worsening shortness of breath, dizziness, chest pain, a fast heartbeat, or swelling in your legs or ankles, as these could be symptoms of high blood pressure in the lungs (pulmonary hypertension).