Clozapine STADA
Clozapine Stada is a medicine used to treat severe schizophrenia and serious thought and behavior problems caused by Parkinson's disease when other medicines haven't helped.
Form
tabletti
Strength
100 mg
Active Ingredient
Clozapine
Manufacturer
STADA Arzneimittel AG
How to Use
Dosage
For schizophrenia, start with 12.5 mg once or twice a day, slowly increasing the dose to 200-450 mg per day. For Parkinson's disease-related thought problems, start with 12.5 mg in the evening, slowly increasing to 25-37.5 mg per day in the evening. Always follow your doctor's instructions for dosage increases.
Method
Swallow the tablets whole with water.
Important
The maximum daily dose for schizophrenia is 900 mg. For Parkinson's disease-related problems, the maximum daily dose is 100 mg. Always use the lowest effective dose.
Possible Side Effects
COMMON
- •Severe constipation.
- •Fast heart rate.
- •Sleepiness.
- •Dizziness.
- •Increased saliva production.
RARE
- •Cold or flu-like symptoms, fever, sore throat, or other signs of infection.
- •Seizures or convulsions.
- •Sudden fainting or loss of consciousness with muscle weakness.
- •Sudden high fever, stiff muscles, which can lead to unconsciousness (Neuroleptic Malignant Syndrome).
- •Feeling strange, unreal, dizzy, or faint when standing up, which increases the risk of falls.
- •Signs of respiratory infection or pneumonia, such as fever, cough, difficulty breathing, or wheezing.
- •Severe, burning pain in the upper abdomen that spreads to the back, with nausea and vomiting (due to inflammation of the pancreas).
- •Fainting and/or muscle weakness due to a significant drop in blood pressure (circulatory collapse).
- •Difficulty swallowing (which can cause food to go down the wrong pipe).
- •Nausea, vomiting, and/or loss of appetite (your liver may need to be checked).
- •Signs of weight gain or increased obesity.
- •Pauses in breathing during sleep, with or without snoring.
- •Fast and irregular heartbeat, even at rest, palpitations, shortness of breath, chest pain, or unexplained tiredness.
- •Persistent painful erection of the penis (priapism).
- •Spontaneous bleeding or bruising, which may be a sign of low platelet count.
- •Symptoms due to uncontrolled blood sugar, such as nausea, vomiting, stomach pain, increased thirst, frequent urination, confusion, or disorientation.
- •Stomach pain, cramps, swollen abdomen, vomiting, constipation, and gas problems (signs of bowel obstruction).
- •Loss of appetite, swollen abdomen, stomach pain, yellow skin, severe weakness, and feeling unwell (signs of liver disease that can lead to liver cell death).
- •Nausea, vomiting, tiredness, weight loss (symptoms of kidney inflammation).
- •Severe chest pain, tightness, pressure in the chest, shortness of breath, sweating, weakness, dizziness, nausea, vomiting, and palpitations (heart attack symptoms). Seek immediate medical attention.
- •Pressure over the chest, heaviness, tightness, burning or choking sensation (signs of insufficient blood flow and oxygen to the heart muscle).
- •Intermittent 'thumping,' 'pounding,' or 'fluttering' feeling in the chest (palpitations).
- •Fast and irregular heartbeats (atrial fibrillation). May cause temporary palpitations, fainting, shortness of breath, or chest pain.
- •Symptoms of low blood pressure like dizziness, lightheadedness, fainting, blurred vision, unusual tiredness, cold sweats, or nausea.
- •Signs of blood clots in the veins, especially in the legs (swelling, pain, and redness in the legs), which can travel to the lungs and cause chest pain and difficulty breathing.
- •Confirmed or suspected infection with fever or low body temperature, abnormally fast breathing, fast heart rate, changes in awareness, and low blood pressure (sepsis symptoms).
- •Heavy sweating, headache, nausea, vomiting, and diarrhea (cholinergic syndrome symptoms).
- •Significantly reduced urine output (signs of kidney failure).
- •Allergic reaction (swelling mainly of the face, mouth, throat, and tongue, which can be itchy or painful).
- •Loss of appetite, swollen abdomen, stomach pain, yellow skin, severe weakness, and feeling unwell (signs of liver diseases where normal liver tissue is replaced by scar tissue, leading to decreased liver function, liver failure, liver damage, and liver transplantation).
- •Burning pain in the upper abdomen, especially between meals or early morning, or after acidic drinks; tar-like, black, or bloody stool; bloating, heartburn, nausea or vomiting, early fullness (stomach and/or intestinal ulcer).
- •Severe stomach pain worsened by movement, nausea, vomiting including blood (or coffee-ground like fluid); stiff abdomen with spreading tenderness; fever and/or chills (ruptured stomach and/or intestine).
- •Constipation, stomach pain, tenderness in the abdomen, fever, swelling, and/or bloody diarrhea (signs of megacolon or bowel infarction/ischemia/necrosis).
- •Sharp chest pain with shortness of breath, with or without coughing.
- •Increased or new muscle weakness, muscle spasms, muscle pain (rhabdomyolysis).
- •Sharp chest or abdominal pain with shortness of breath, with or without cough or fever.
- •Very intense and severe skin reactions, such as drug rash with eosinophilia and systemic symptoms (DRESS syndrome). Symptoms may include rash with or without blisters, skin irritation, swelling, fever, and flu-like symptoms.
- •High white blood cell count (leukocytosis), high count of a specific type of white blood cells (eosinophilia).
- •Blurred vision.
- •Headache.
- •Tremors, stiffness, restlessness, muscle twitching, abnormal movements, difficulty starting movements, difficulty staying still.
- •Changes in heart's electrical activity (ECG changes).
- •High blood pressure.
- •Weakness or strange, unreal feeling after changing body position.
- •Dry mouth.
- •Minor abnormal liver function test results.
- •Urinary incontinence, difficulty urinating.
- •Tiredness, fever, increased sweating, increased body temperature, speech problems (e.g., slurred speech).
- •Low white blood cell count (agranulocytosis), speech problems (e.g., stuttering).
- •Low red blood cell count (anemia).
- •Restlessness, agitation, confusion, delirium.
- •Irregular heartbeat, inflammation of the heart muscle (myocarditis) or the membrane around the heart muscle (pericarditis), fluid accumulation around the heart (pericardial effusion).
- •High blood sugar, diabetes mellitus.
- •Blood clots in the lungs (pulmonary embolism).
- •Liver inflammation (hepatitis), liver disease causing yellow skin, dark urine, and itching.
- •High levels of an enzyme called creatine phosphokinase in the blood.
- •Increased platelet count with a risk of blood clots.
- •Involuntary movements of the mouth, tongue, arms, and legs.
- •Obsessive thoughts and repetitive compulsive behaviors (OCD symptoms).
- •Skin reactions.
- •Swelling in front of the ear (enlargement of the salivary glands).
- •Difficulty breathing.
- •Very high levels of triglycerides or cholesterol in the blood.
- •Heart muscle disease (cardiomyopathy).
- •Cardiac arrest.
- •Sudden unexplained death.
- •Changes in brain activity (seen on EEG).
- •Diarrhea.
- •Unpleasant feeling in the stomach, heartburn, stomach pain after meals.
- •Muscle weakness, muscle cramps, muscle pain.
- •Stuffy nose.
- •Bedwetting.
- •Sudden, uncontrolled increase in blood pressure (pseudopheochromocytoma).
- •Uncontrolled twisting of the body to one side (pleurothotonus).
- •Ejaculation problems in men where semen goes into the bladder instead of out the penis (dry orgasm or retrograde ejaculation).
- •Rash, purple-red spots, fever or itching due to blood vessel inflammation.
- •Colon inflammation causing diarrhea, abdominal pain, fever, skin color changes, facial 'butterfly rash,' joint pain, muscle pain, fever, and weakness (lupus erythematosus).
- •Restless legs syndrome (irresistible urge to move legs or arms, usually with unpleasant feelings at rest, especially in the evening or night, temporarily relieved by movement).
Important Warnings
- Do not take this medicine if you are allergic to clozapine or any other ingredients.
- You must be able to have regular blood tests. Do not take this medicine if you cannot.
- Do not take this medicine if you have ever had a low white blood cell count, especially if it was caused by other medicines.
- Do not take this medicine if you had to stop clozapine treatment before due to severe side effects like very low white blood cell count or heart problems.
- Do not take this medicine if you are being treated or have been treated with long-acting antipsychotic injections.
Show 22 more warnings
- Do not take this medicine if you have or have had a bone marrow disease.
- Do not take this medicine if you have uncontrolled epilepsy (seizures).
- Do not take this medicine if you have a severe mental illness caused by alcohol or drugs.
- Do not take this medicine if you have reduced awareness or are very sleepy.
- Do not take this medicine if you have circulatory collapse from severe shock.
- Do not take this medicine if you have severe kidney, heart (like myocarditis), or liver disease (with symptoms like yellow skin, nausea).
- Do not take this medicine if you have paralytic ileus (bowel blockage) or severe constipation.
- Do not take this medicine if you are taking medicines that stop your bone marrow from working normally or reduce your white blood cells.
- Do not give this medicine to someone who is unconscious or in a coma.
- Tell your doctor if you or your family have had blood clots, as this medicine can increase the risk.
- Tell your doctor if you have high eye pressure (glaucoma), diabetes, prostate problems, or difficulty urinating.
- Tell your doctor if you have long-term constipation or take medicines that cause constipation.
- Tell your doctor if you have controlled epilepsy, colon disease, or have had abdominal surgery.
- Tell your doctor if you or your family have had heart rhythm problems (prolonged QT interval) or if you have a high risk of stroke (e.g., high blood pressure, heart problems).
- Contact your doctor immediately before taking your next dose if you get cold or flu-like symptoms, fever, sore throat, or other signs of infection.
- Contact your doctor immediately if you have a sudden high fever and/or stiff muscles, which could lead to unconsciousness (Neuroleptic Malignant Syndrome).
- Contact your doctor immediately if you have a fast and irregular heartbeat, even at rest, or feel palpitations, shortness of breath, chest pain, or unexplained tiredness.
- Contact your doctor immediately if you have nausea, vomiting, and/or loss of appetite, as your liver may need to be checked.
- Contact your doctor immediately if you have severe constipation that needs medical treatment to prevent other problems.
- Contact your doctor immediately if you have constipation, stomach pain, tenderness in the abdomen, fever, swelling, and/or bloody diarrhea.
- This medicine can cause tiredness, sleepiness, and seizures, especially when you start taking it. Do not drive or use machines if you have these symptoms.
- Do not change your dose or stop taking this medicine without talking to your doctor first, as stopping suddenly can cause withdrawal symptoms.