Cisplatin Ebewe
Cisplatin is a cancer medicine (cytostatic) used alone or with other medicines to destroy cancer cells.
Form
infuusiokonsentraatti, liuosta varten
Strength
1 mg/ml
Active Ingredient
Cisplatin
Manufacturer
Ebewe Pharma Ges.m.b.H. Nfg.KG
How to Use
Dosage
Your doctor will decide your dose based on your condition; it can be 50–120 mg/m² as a single dose every 3–4 weeks, or 15–20 mg/m² daily for five days every 3–4 weeks, or 20 mg/m² or more every 3–4 weeks in combination therapy.
Method
The medicine is given as a drip into a vein.
Important
Generally, up to 20 mg/m² per day when the medicine is given over several days, though higher single doses (up to 120 mg/m²) are given less often.
Possible Side Effects
COMMON
- •Low white blood cell count, increasing the risk of infection (leukopenia).
- •Low platelet count, increasing the risk of bruising and bleeding (thrombocytopenia).
- •Low red blood cell count, which can cause pale skin, weakness, or shortness of breath (anemia).
- •Bone marrow failure (no production of blood cells).
- •Low blood sodium levels.
- •Fever.
- •Sepsis (blood poisoning).
- •Heart rhythm problems, including slow heartbeat (bradycardia) and fast heartbeat (tachycardia).
- •Shortness of breath (dyspnea), lung inflammation (pneumonia), and respiratory failure.
- •Persistent or severe diarrhea or vomiting.
- •Inflammation of the mouth/mucosa (sore lips or sores in the mouth).
- •Swelling of the face, lips, mouth, or throat.
- •Unexplained respiratory symptoms, such as dry cough, difficulty breathing, or wheezing.
- •Difficulty swallowing.
- •Numbness or tingling in the fingers or toes.
- •Extreme fatigue or weakness.
- •Abnormal bruising or bleeding.
- •Signs of infection, such as sore throat or fever.
- •Unpleasant feeling at or near the injection site during infusion.
- •Severe pain or swelling in one or both legs, chest pain, or difficulty breathing (possible signs of blood clots).
RARE
- •Decreased sperm and egg production, and painful breast enlargement in men (gynecomastia).
- •Acute leukemia.
- •Low blood magnesium levels (hypomagnesemia).
- •Hearing damage (ototoxicity) or deafness.
- •Metallic taste or loss of taste.
- •Various brain disorders (leukoencephalopathy).
- •High blood cholesterol levels (hypercholesterolemia).
- •Seizures.
- •Numbness, tingling, or burning sensation (peripheral neuropathy).
- •Abnormal brain changes, which can cause symptoms like headache, confusion, seizures, and vision loss (reversible posterior leukoencephalopathy syndrome).
- •Heart attacks.
- •Inflammation of the oral mucosa (stomatiitti).
- •Increased blood iron levels.
- •Heart stops pumping blood (cardiac arrest).
- •Breakdown of red blood cells (Coombs-positive hemolytic anemia).
- •Increase in levels of a certain enzyme (amylase).
- •Syndrome of inappropriate ADH secretion, causing fluid retention, electrolyte imbalance, and low blood sodium ('water intoxication').
- •Dehydration.
- •Low blood electrolyte levels (potassium, phosphate, calcium).
- •Increased uric acid levels in the blood.
- •Muscle cramps or spasms (tetany).
- •Stroke.
- •Inflammation in brain blood vessels.
- •Sudden sharp pain from the neck radiating down the back and legs when bending forward (Lhermitte's sign).
- •Spinal cord compression (myelopathy).
- •Nerve damage affecting involuntary body functions (can affect blood pressure, temperature control, digestion, bladder function).
- •Blurred vision, color blindness, vision loss (blindness), optic nerve inflammation, swelling around the optic nerve (papilledema), or retinal pigmentation.
- •Ringing, buzzing, hissing, clicking, or other sounds in the ears.
- •Heart problems.
- •Hemolytic uremic syndrome (a combination of red blood cell breakdown, kidney failure, and low platelets).
- •Pale and bluish fingers or toes (Raynaud's phenomenon).
- •Loss of appetite.
- •Hiccups.
- •Increased blood enzyme levels, which may be a sign of liver damage.
- •Blood clots in the lungs.
- •Rash.
- •Hair loss (alopecia).
- •Worsened or complete loss of kidney function.
- •Redness, inflammation, swelling, and pain at the injection site due to the medicine leaking into surrounding tissues instead of the vein.
Important Warnings
- Do not use if you are allergic to cisplatin or any other ingredient in this medicine, or to other platinum-containing medicines.
- Do not use if you have kidney problems.
- Do not use if you are dehydrated.
- Do not use if you have a low blood cell count.
- Do not use if you have hearing problems.
Show 11 more warnings
- If you are pregnant, breastfeeding, or planning to become pregnant, talk to your doctor. You must use effective contraception during and for at least 7 months after treatment.
- Do not use if you are receiving a yellow fever vaccine or phenytoin at the same time.
- If you have a nervous system disorder not caused by cisplatin, discuss it with your doctor.
- If you have an infection, contact your doctor.
- If you experience vomiting or diarrhea after cisplatin treatment, you need to replace lost fluids.
- Men receiving cisplatin treatment should not father a child during treatment and for at least 4 months afterward. Men should also consider sperm banking before starting treatment.
- Do not drive or operate machinery that requires full attention, as cisplatin may cause drowsiness and/or vomiting.
- Cisplatin must not come into contact with any aluminum-containing materials.
- Your doctor will perform blood tests to check calcium, sodium, potassium, and magnesium levels, as well as blood count, and liver and kidney function. Your hearing will also be tested before each dose.
- Cisplatin must always be given under strict supervision by a specialist experienced in cancer treatment.
- If cisplatin is injected outside the vein, stop administration immediately as it can cause tissue damage. If cisplatin spills on the skin, wash the affected area immediately with soap and water.