Celecoxib Krka
Celecoxib Krka is a medicine that reduces pain and inflammation for adults with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Form
kapseli, kova
Strength
200 mg
Active Ingredient
Celecoxib
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
The usual dose is 200 mg per day. Your doctor may change your dose if needed.
Method
Swallow the capsule whole with water. You can take it with or without food, but try to take it at the same time each day.
Important
Do not take more than 400 mg of Celecoxib Krka capsules per day.
Possible Side Effects
COMMON
- •High blood pressure, or worsening of existing high blood pressure.
- •Heart attack.
- •Swelling in ankles, feet, or hands due to fluid buildup.
- •Urinary tract infections.
- •Breathing problems, sinus infection, stuffy or runny nose, sore throat, cough, cold or flu-like symptoms.
- •Dizziness, trouble sleeping.
- •Vomiting, stomach pain, diarrhea, indigestion, gas.
- •Rash, itching.
- •Muscle stiffness.
- •Difficulty swallowing.
- •Headache.
- •Nausea (feeling sick).
- •Joint pain.
- •Worsening of existing allergies.
- •Injury from accident.
RARE
- •Stroke.
- •Heart failure, heart palpitations (feeling your heartbeat), fast heartbeat.
- •Abnormal liver tests.
- •Abnormal kidney tests.
- •Anemia (low red blood cells, causing tiredness and shortness of breath).
- •Anxiety, depression, tiredness, drowsiness, tingling skin.
- •High potassium levels in blood (can cause nausea, tiredness, muscle weakness or palpitations).
- •Blurred or reduced vision, ringing in ears (tinnitus), mouth pain or sores, hearing problems.
- •Constipation, burping, stomach inflammation (indigestion, stomach pain or vomiting), worsening of stomach or bowel inflammation.
- •Leg cramps.
- •Hives (itchy rash).
- •Eye inflammation.
- •Difficulty breathing.
- •Skin discoloration (bruising).
- •Chest pain (general pain not related to heart).
- •Swelling of the face.
- •Stomach, esophagus, or bowel ulcers (bleeding), or bowel perforation (can cause stomach pain, fever, nausea, vomiting, bowel blockage), black or bloody stools, pancreas inflammation (stomach pain), esophagus inflammation.
- •Low sodium levels in blood (hyponatremia).
- •Decreased white blood cells (body's defense against infection), decreased platelets (increased risk of bleeding or bruising).
- •Muscle coordination problems.
- •Confusion, taste changes.
- •Increased sensitivity to light.
- •Hair loss.
- •Hallucinations.
- •Bleeding in the eye.
- •Sudden reaction that can lead to lung inflammation.
- •Irregular heartbeat.
- •Redness and flushing.
- •Blood clot in lung blood vessels (pulmonary embolism), with symptoms like sudden shortness of breath, sharp pain when breathing, or fainting.
- •Bleeding in stomach or intestines (can cause blood in stools or vomit), small or large bowel inflammation.
- •Severe liver inflammation (hepatitis), with symptoms like nausea, diarrhea, yellow skin or eyes, dark urine, pale stools, easy bleeding, itching, or chills.
- •Sudden kidney failure.
- •Menstrual problems.
- •Swelling of face, lips, tongue, or throat, or difficulty swallowing.
- •Severe allergic reactions (including life-threatening anaphylactic shock).
- •Severe skin diseases (like Stevens-Johnson syndrome, peeling skin, widespread rash with small pus-filled blisters).
- •Delayed allergic reaction (with symptoms like rash, facial swelling, fever, swollen glands, and abnormal blood/liver tests).
- •Life-threatening brain bleeding.
- •Brain and spinal cord membrane inflammation (meningitis).
- •Liver failure, liver damage, severe liver inflammation (fulminant hepatitis), sometimes leading to death or transplant, with symptoms like nausea, diarrhea, yellow skin or eyes, dark urine, pale stools, easy bleeding, itching, or chills.
- •Liver problems (like cholestasis or cholestatic hepatitis), with symptoms like discolored stools, nausea, and yellow skin or eyes.
- •Kidney inflammation and other kidney problems (like nephrotic syndrome, with symptoms like fluid retention, foamy urine, tiredness, and loss of appetite).
- •Worsening of epilepsy (possibly more or more severe seizures).
- •Partial or complete loss of vision due to a blocked blood vessel in the eye.
- •Blood vessel inflammation (vasculitis), with symptoms like fever, pain, dark purple spots on skin.
- •Lack of all blood cells (pancytopenia), causing tiredness, easy bruising, frequent nosebleeds, and increased infection risk.
- •Muscle pain and weakness.
- •Decreased sense of smell.
- •Loss of taste.
- •Decreased fertility in women (usually goes away after stopping the medicine).
Important Warnings
- Do not take if you are allergic to celecoxib or any other ingredient in this medicine.
- Do not take if you have had an allergic reaction to sulfonamide medicines (like some antibiotics).
- Do not take if you currently have a stomach ulcer or bleeding in your stomach or intestines.
- Do not take if you have had asthma, nasal polyps, severe stuffy nose, or an allergic reaction (like rash, swelling of face/lips/tongue/throat, breathing difficulty) after taking aspirin or other pain/inflammation medicines.
- Do not take if you are pregnant or planning to become pregnant.
Show 21 more warnings
- Do not take if you are breastfeeding.
- Do not take if you have severe liver disease.
- Do not take if you have severe kidney disease.
- Do not take if you have an inflammatory bowel disease (like ulcerative colitis or Crohn's disease).
- Do not take if you have heart failure, known heart disease (like a heart attack, stroke, chest pain), or blockages in heart or brain blood vessels.
- Do not take if you have or have had circulation problems (peripheral artery disease) or surgery on arteries in your legs.
- Tell your doctor if you have had a stomach ulcer or bleeding in your stomach or intestines in the past.
- Tell your doctor if you take aspirin, even low doses for your heart.
- Tell your doctor if you take medicines to prevent blood clots (antiplatelets).
- Tell your doctor if you take blood thinners (like warfarin or apixaban).
- Tell your doctor if you take steroid medicines (like prednisone).
- Do not take other anti-inflammatory pain medicines (like ibuprofen or diclofenac) with Celecoxib Krka.
- Tell your doctor if you smoke, have diabetes, high blood pressure, or high cholesterol.
- Tell your doctor if your heart, liver, or kidneys do not work well.
- Tell your doctor if you have fluid buildup (swelling in your ankles and feet).
- Tell your doctor if you are dehydrated (for example, from illness, diarrhea, or taking diuretics).
- Tell your doctor if you have had a severe allergic reaction or severe skin reaction to any medicine.
- Tell your doctor if you feel sick due to an infection or suspect you have one, as Celecoxib Krka can hide fever and other signs of infection.
- Tell your doctor if you are over 65 years old.
- Avoid alcohol with Celecoxib Krka as it may increase the risk of stomach and bowel problems.
- This medicine can cause severe liver problems. Contact your doctor immediately if you have symptoms like nausea, diarrhea, yellow skin or eyes.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. For short-term use only. Consider adverse renal effect in chronic kidney disease. Do not use in severe renal impairment. May increase swelling. Worsens renal and cardiac failure and causes cardiovascular events. Risk of gastrointestinal bleeding less than with traditional NSAIDs. Consider potential interactions especially with preparations that increase risk of bleeding. (updated 16.9.2024)