Bortezomib Viatris
Bortezomib Viatris is a proteasome inhibitor that helps control cell function and growth, thus destroying cancer cells.
Form
injektiokuiva-aine, liuosta varten
Strength
3.5 mg
Active Ingredient
Bortezomib
Manufacturer
Viatris Limited
How to Use
Dosage
The usual starting dose is 1.3 mg/m² of body surface area.
Method
This medicine is given as an injection into a vein (intravenously) or under the skin (subcutaneously) by a healthcare professional. Intravenous injections are given quickly (3-5 seconds), while subcutaneous injections are given into the thigh or abdomen.
Important
The medicine is typically given twice a week, and the total number of treatment cycles is limited, for example, up to 8 cycles (24 weeks) depending on the treatment plan.
Possible Side Effects
COMMON
- •Nerve damage causing sensitivity, numbness, tingling, warmth, or pain in hands or feet.
- •Decrease in red and/or white blood cell count.
- •Fever.
- •Nausea and vomiting, decreased appetite.
- •Constipation, possibly with bloating (can be severe).
- •Diarrhea; if this occurs, drink more water than usual and your doctor may prescribe other medicine for diarrhea.
- •Tiredness (fatigue), feeling weak.
- •Muscle pain, bone pain.
- •Hair loss and abnormal hair structure.
- •Low blood pressure, sudden drop in blood pressure when standing, which can lead to fainting.
- •High blood pressure.
- •Impaired kidney function.
- •Headache.
- •General malaise, pain, spinning sensation, dizziness, weakness, or loss of consciousness.
- •Chills.
- •Infections such as pneumonia, respiratory tract infections, bronchitis, fungal infections, cough with mucus, flu-like illness.
- •Shingles (localized, around the eyes, or spread across the body).
- •Chest pain, shortness of breath during physical activity.
- •Various rashes.
- •Itchy skin, skin lumps, or dry skin.
- •Facial flushing or broken capillaries.
- •Skin redness.
- •Dehydration.
- •Heartburn, bloating, belching, flatulence, stomach pain, bleeding from intestines or stomach.
- •Soreness of mouth or lips, dry mouth, mouth sores, or sore throat.
- •Weight loss, loss of taste.
- •Muscle cramps, spasms, muscle weakness, limb pain.
- •Blurred vision.
- •Infection of the outer layer of the eye and inner surface of the eyelid (conjunctivitis).
- •Nosebleed.
- •Sleep difficulties or disturbances, sweating, anxiety, mood swings, sadness, restlessness or agitation, changes in mental state, disorientation.
- •Body swelling, including swelling around the eyes and other body parts.
- •Redness or pain at the injection site.
- •General malaise.
- •Weight gain.
RARE
- •Heart problems, including heart attack, chest pain on exertion (angina pectoris), heart failure, chest discomfort, slow or fast heart rate.
- •Kidney dysfunction or kidney cancer.
- •Blood vessel inflammation or bleeding, blood clots in veins and lungs.
- •Insufficient blood circulation.
- •Inflammation of the sac around the heart or fluid around the heart.
- •Infections such as urinary tract infections, flu, herpes virus infections, ear infections, cellulitis, bacterial and viral infections, tooth infection.
- •Bloody stools or bleeding from mucous membranes, e.g., in the mouth, vagina.
- •Cerebrovascular disorders, brain hemorrhage.
- •Paralysis, seizures, falls, movement disorders, abnormal or decreased senses (touch, hearing, taste, smell), concentration problems, tremors, twitching.
- •Joint inflammation, including inflammation of fingers, toes, and jaws.
- •Lung disorders where the body doesn't get enough oxygen, including breathing difficulties, shortness of breath, shortness of breath without exertion, shallow, labored or intermittent breathing, wheezing.
- •Hiccups, speech disorders.
- •Increased or decreased urine production (due to kidney damage), painful urination, blood/protein in urine, fluid retention.
- •Altered consciousness, confusion, memory impairment or memory loss.
- •Hypersensitivity.
- •Hearing loss, deafness or ringing in ears, ear discomfort.
- •Hormone disorder that may affect salt and water absorption, overactive or underactive thyroid, inability to produce enough insulin or reduced effect of normal insulin levels.
- •Eye irritation or inflammation, very watery eyes, sore eyes, dry eyes, eye infections, eyelid cyst (chalazion), red and swollen eyelids, eye discharge, abnormal vision, eye bleeding.
- •Swollen lymph nodes.
- •Stiff joints or muscles, feeling of heaviness, groin pain.
- •Allergic reactions.
- •Mouth pain.
- •Mouth infections or inflammation, mouth sores, esophageal, stomach, and intestinal ulcers sometimes with pain or bleeding, slowed bowel movements (including bowel obstruction), abdominal or esophageal discomfort, difficulty swallowing, vomiting blood.
- •Skin infections.
- •Pancreatitis, bile duct obstruction.
- •Genital pain, erectile dysfunction.
- •Thirst.
- •Changed liver function or hepatitis.
- •Disorders related to the injection site or administration device.
- •Skin reactions and disorders (which can be severe and life-threatening), skin wounds, bruises, falls, and injuries.
- •Blood vessel inflammation or bleeding, which may appear as small red or purple spots (usually on legs) or large bruise-like patches under the skin or tissue.
- •Benign cysts.
- •Severe reversible brain condition, including seizures, high blood pressure, headache, fatigue, confusion, blindness, or other vision problems.
- •Facial and neck flushing.
- •Blood vessel discoloration.
- •Spinal cord nerve inflammation.
- •Ear problems, bleeding from ear.
- •Budd-Chiari syndrome (clinical symptoms caused by liver vein obstruction).
- •Changes or abnormalities in bowel function.
- •Yellowing of eyes and skin (jaundice).
- •Severe allergic reactions (anafylactic shock), symptoms of which may include difficulty breathing, chest pain or tightness, dizziness/lightheadedness, severe skin itching or raised welts, swelling of face, lips, tongue, and/or throat, which may cause difficulty swallowing, loss of consciousness.
- •Breast disorders.
- •Genital ulcers.
- •Swelling of genitals.
- •Alcohol intolerance.
- •Increased appetite.
- •Fistulas.
- •Joint fluid effusion.
- •Cysts on joint surfaces (synovial cysts).
- •Fractures.
- •Muscle tissue breakdown, leading to other complications.
- •Liver swelling, liver bleeding.
- •Psoriasis-like skin disease.
- •Skin cancer.
- •Pale skin.
- •Increase in platelets or plasma cells (a type of white blood cell) in the blood.
- •Small blood vessel blockage (thrombotic microangiopathy).
- •Abnormal reaction to blood transfusion.
- •Partial or total vision loss.
- •Decreased sex drive.
- •Drooling.
- •Severe nerve inflammation that can cause paralysis and breathing difficulties (Guillain-Barré syndrome).
- •Protruding eyeballs.
- •Photosensitivity.
- •Rapid breathing.
- •Rectal pain.
- •Gallstones.
- •Hernia.
- •Brittle or weak nails.
- •Abnormal protein deposits in vital organs.
- •Coma.
- •Intestinal ulcers.
- •Multi-organ failure.
- •Death.
Important Warnings
- Do not use if you are allergic to bortezomib, boron, or any other ingredients in this medicine.
- Do not use if you have certain severe lung or heart diseases.
- Tell your doctor if you have low red or white blood cell counts.
- Tell your doctor if you have bleeding disorders or low platelet count.
- Tell your doctor if you have diarrhea, constipation, nausea, or vomiting.
Show 13 more warnings
- Tell your doctor if you have a history of fainting, dizziness, or lightheadedness.
- Tell your doctor if you have kidney problems.
- Tell your doctor if you have moderate to severe liver problems.
- Tell your doctor if you have a history of numbness, tingling, or pain in your hands or feet (neuropathy).
- Tell your doctor if you have heart problems or blood pressure issues.
- Tell your doctor if you have shortness of breath or a cough.
- Tell your doctor if you have had seizures.
- Tell your doctor if you have shingles (localized, around the eyes, or spread across the body).
- Tell your doctor if you have symptoms of tumor lysis syndrome, such as muscle cramps, weakness, confusion, vision loss or blurred vision, and shortness of breath.
- Tell your doctor if you experience memory loss, difficulty thinking, problems walking, or vision loss, as these could be symptoms of a serious brain infection.
- Do not use Bortezomib Viatris if you are pregnant, unless absolutely necessary. Do not breastfeed during treatment.
- Both men and women must use effective contraception during treatment with Bortezomib Viatris and for 3 months after treatment ends.
- This medicine may cause tiredness, dizziness, fainting, or blurred vision. Do not drive or use machines if you experience these side effects.