Bendamustine Medac
Bendamustine medac is a medicine that contains bendamustine hydrochloride and is used to treat certain types of cancer.
Form
kuiva-aine välikonsentraatiksi infuusionestettä varten, liuos
Strength
2.5 mg/ml
Active Ingredient
Bendamustine hydrochloride
Manufacturer
Medac Gesellschaft Für Klinische Spezialpräparate mbH
How to Use
Dosage
Your doctor will determine the exact dose for you based on your condition and body size.
Method
The medicine is given as a drip into a vein (intravenous infusion) over 30 to 60 minutes.
Important
The maximum dose and total treatment duration are determined by your doctor.
Possible Side Effects
COMMON
- •Low white blood cell count
- •Decreased red blood cell count (hemoglobin)
- •Low platelet count
- •Infections
- •Nausea
- •Vomiting
- •Inflammation of mucous membranes
- •Increased blood creatinine levels
- •Increased blood urea levels
- •Fever
- •Fatigue
- •Headache
- •Bleeding
- •Metabolic disorders due to waste products released from dying cancer cells (tumor lysis syndrome)
- •Anemia (decreased red blood cells, causing paleness, weakness, or shortness of breath)
- •Low neutrophil count
- •Allergic reactions (e.g., skin inflammation, hives)
- •Increased liver enzyme levels (ASAT/ALAT)
- •Increased alkaline phosphatase enzyme levels
- •Increased bilirubin levels
- •Low potassium levels in blood
- •Heart problems (palpitations, chest pain), irregular heartbeats
- •Low or high blood pressure
- •Lung function problems
- •Diarrhea
- •Constipation
- •Mouth pain (stomatitis)
- •Loss of appetite
- •Hair loss
- •Skin changes
- •Missed menstrual periods
- •Pain
- •Insomnia
- •Chills
- •Dehydration
- •Dizziness
- •Itchy hives
RARE
- •Fluid accumulation around the heart
- •Insufficient production of all blood cell types (myelodysplastic syndrome)
- •Acute leukemia
- •Heart attack, chest pain
- •Heart failure
- •Blood poisoning (sepsis)
- •Severe allergic reactions
- •Symptoms resembling allergic reactions
- •Drowsiness
- •Loss of voice
- •Acute circulatory failure
- •Skin redness
- •Skin inflammation
- •Itching
- •Macular rash
- •Heavy sweating
- •Bone marrow failure (can cause feeling unwell and show in blood tests)
- •Atypical pneumonia
- •Red blood cell breakdown
- •Sudden drop in blood pressure (sometimes with skin reactions or rash, anaphylactic shock)
- •Taste disturbance
- •Sensory disturbances (e.g., tingling, numbness, crawling sensation)
- •Discomfort and pain in arms and legs (peripheral neuropathy)
- •Nervous system disorder (anticholinergic syndrome)
- •Neurological disorders
- •Impaired coordination
- •Brain inflammation
- •Increased heart rate
- •Vein inflammation
- •Lung scarring (pulmonary fibrosis)
- •Esophageal inflammation with bleeding
- •Stomach or intestinal bleeding
- •Infertility
- •Multiple organ failure
- •Liver failure
- •Kidney failure
- •Irregular and often fast heartbeat (atrial fibrillation)
- •Painful, red or purple rash with blisters, peeling skin, or sores on mucous membranes (mouth, genitals), especially if sensitive to light, respiratory infection, or fever.
- •Drug rash with rituximab combination therapy
- •Lung inflammation (pneumonitis)
- •Lung bleeding
- •Excessive urination, including at night, and strong thirst even after drinking fluids (nephrogenic diabetes insipidus).
Important Warnings
- Do not use if you are allergic to bendamustine hydrochloride or any other ingredients in this medicine.
- Do not use if you are breastfeeding; if treatment is necessary, you must stop breastfeeding.
- Do not use if you have severe liver problems or yellowing of the skin or eyes (jaundice) due to liver or blood issues.
- Do not use if your bone marrow is severely suppressed, meaning you have very low white blood cell or platelet counts.
- Do not use if you have had major surgery within 30 days before starting treatment.
Show 11 more warnings
- Do not use if you have an infection, especially if your white blood cell count is low.
- Do not use with yellow fever vaccination.
- Contact your doctor immediately if you notice memory loss, thinking difficulties, walking problems, or vision loss, as these could be signs of a serious brain infection (PML).
- Report any suspicious skin changes to your doctor, as this medicine may increase the risk of certain skin cancers.
- Seek immediate medical attention if you experience severe skin rashes, including red spots, blisters, skin peeling, or sores in the mouth, nose, eyes, or genitals, possibly with fever.
- Tell your doctor if you experience side pain, blood in urine, or reduced urine, as these can be signs of tumor lysis syndrome.
- Be aware of severe allergic or infusion reactions, especially after the first treatment cycle.
- This medicine can significantly affect your ability to drive or use machines. Do not drive or operate machinery if you experience side effects like dizziness or coordination problems.
- Men undergoing treatment should avoid fathering children during treatment and for 6 months afterward, as the treatment may cause permanent infertility.
- Women who can become pregnant must use effective contraception during treatment and for 6 months after.
- Men must use effective contraception and should not father children during treatment and for 3 months after.