Bendamustine Accord
Bendamustine Accord is a medicine used to treat certain types of cancer.
Form
kuiva-aine välikonsentraatiksi infuusionestettä varten, liuos
Strength
2.5 mg/ml
Active Ingredient
Bendamustine hydrochloride
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
The dosage is calculated based on your body surface area (height and weight) and varies depending on the type of cancer; it's given on specific days in treatment cycles.
Method
This medicine is given as an infusion (drip) into a vein over 30-60 minutes.
Important
Your doctor will decide your maximum daily dose based on your specific condition and blood tests.
Possible Side Effects
COMMON
- •Low white blood cell counts
- •Decreased hemoglobin levels (protein in red blood cells that carries oxygen)
- •Low platelet counts (cells that help blood clot)
- •Infections
- •Nausea
- •Vomiting
- •Mucositis (inflammation of mucous membranes)
- •Increased blood creatinine levels (waste product from muscles)
- •Increased blood urea levels (waste product)
- •Fever
- •Fatigue
- •Headache
- •Bleeding
- •Metabolic changes due to breakdown of cancer cells
- •Anemia (low red blood cells causing paleness, weakness, shortness of breath)
- •Low neutrophil counts (a type of white blood cell important for fighting infections)
- •Hypersensitivity reactions (e.g., allergic rash, hives)
- •Increased liver enzyme levels (ASAT/ALAT), which can indicate liver inflammation or damage
- •Increased alkaline phosphatase levels (an enzyme mainly produced in the liver and bones)
- •Increased bile pigment levels (a substance formed during normal red blood cell breakdown)
- •Decreased blood potassium levels (important for nerve and muscle cells, including the heart)
- •Heart function disorders
- •Cardiac arrhythmias (irregular heartbeat)
- •Low or high blood pressure
- •Lung function disorders
- •Diarrhea
- •Constipation
- •Mouth pain (stomatitis)
- •Loss of appetite
- •Hair loss
- •Skin changes
- •Absence of menstruation
- •Pain
- •Insomnia
- •Chills
- •Dehydration
- •Dizziness
- •Itchy hives
RARE
- •Fluid buildup around the heart (pericardial effusion)
- •Insufficient production of all types of blood cells in the bone marrow
- •Acute leukemia
- •Heart attack, chest pain (myocardial infarction)
- •Heart failure
- •Blood poisoning (sepsis)
- •Severe allergic hypersensitivity reactions (anaphylactic reactions)
- •Anaphylactoid reactions (symptoms similar to anaphylaxis)
- •Drowsiness
- •Hoarseness
- •Acute circulatory failure (sudden drop in blood pressure and flow)
- •Skin redness (erythema)
- •Rash (dermatitis)
- •Itching (pruritus)
- •Macular rash
- •Excessive sweating (hyperhidrosis)
- •Bone marrow failure (which may cause malaise and show in blood tests)
- •Primary atypical pneumonia
- •Breakdown of red blood cells (hemolysis)
- •Rapid drop in blood pressure, sometimes with skin reactions or rash (anaphylactic shock)
- •Taste disorders
- •Sensory disturbances (paraesthesia)
- •Peripheral nerve damage (discomfort and pain in limbs)
- •Serious condition causing nerve receptor dysfunction (anticholinergic syndrome)
- •Nervous system disorders
- •Coordination disorders (ataxia)
- •Encephalitis (brain inflammation)
- •Rapid heartbeat (tachycardia)
- •Vein inflammation (phlebitis)
- •Lung fibrosis (scarring of lung tissue)
- •Esophagitis with bleeding
- •Gastrointestinal bleeding (stomach or intestinal)
- •Infertility
- •Multiple organ failure
- •Kidney failure
- •Liver failure
- •Irregular and often fast heartbeat (atrial fibrillation)
- •Severe painful, red or purple rash with blisters that spread and may involve mucous membranes (e.g., mouth, lips), possibly with fever (Stevens-Johnson syndrome, toxic epidermal necrolysis).
- •Drug rash in combination with rituximab
- •Pneumonitis (lung inflammation)
- •Pulmonary hemorrhage (lung bleeding)
- •Excessive urination, even at night, and excessive thirst even after drinking fluids (nephrogenic diabetes insipidus)
Important Warnings
- Do not use if you are allergic to bendamustine hydrochloride or any other ingredients in this medicine.
- Do not breastfeed during treatment.
- Do not use if you have severe liver problems or yellowing of the skin or eyes (jaundice).
- Do not use if your bone marrow is severely weakened, leading to very low white blood cell or platelet counts. Your doctor will check these regularly.
- Do not use if you have had major surgery within 30 days before starting treatment.
Show 9 more warnings
- Do not use if you have an infection, especially with a low white blood cell count.
- Do not use if you have recently received a yellow fever vaccine.
- Tell your doctor immediately if you develop severe painful, spreading red or purple rashes, blisters, or peeling skin, especially on your mouth, lips, eyes, or genitals, potentially with fever.
- Tell your doctor if you have a history of heart disease, like a heart attack, chest pain, or severe irregular heartbeats.
- Contact your doctor if you experience side pain, blood in your urine, or reduced urine output, as this could be tumor lysis syndrome, causing kidney or heart problems.
- Tell your doctor if you have a severe allergic reaction or hypersensitivity, especially if you get reactions during or after your first infusion.
- Seek medical help immediately if you or someone else notices memory loss, difficulty thinking, trouble walking, or vision loss, as these can be signs of a rare but serious brain infection called PML.
- Contact your doctor if you notice any new or suspicious skin changes, as this medicine may increase your risk of certain types of skin cancer.
- Seek medical attention if you experience a widespread rash, high body temperature, swollen lymph nodes, and symptoms affecting other organs (DRESS reaction).