Adport
Adport is a medicine that weakens your immune system to help prevent your body from rejecting a transplanted organ.
Form
kapseli, kova
Strength
2 mg
Active Ingredient
Tacrolimus monohydrate
Manufacturer
Sandoz A/S
How to Use
Dosage
Your doctor will determine your exact dose based on your weight and health, usually between 0.075-0.30 mg per kg of body weight per day.
Method
Take two doses daily, usually morning and evening. Take on an empty stomach, at least 1 hour before or 2-3 hours after food. Swallow capsules whole with a glass of water immediately after removing them from the blister pack.
Important
Your doctor will regularly adjust your dose, and they will tell you your maximum daily dose.
Possible Side Effects
COMMON
- •High blood sugar, diabetes, high potassium in blood.
- •Sleep problems.
- •Tremors, headache.
- •High blood pressure.
- •Abnormal liver function tests.
- •Diarrhea, nausea.
- •Kidney problems.
- •Decreased blood cells (platelets, red or white blood cells), increased white blood cells, changes in red blood cells (seen in blood tests).
- •Low levels of magnesium, phosphate, potassium, calcium or sodium in blood, fluid retention, high uric acid or blood fats, poor appetite, increased blood acidity, other blood salt changes.
- •Anxiety, confusion, depression, mood changes, nightmares, hallucinations, and other mental problems.
- •Seizures, problems with consciousness, tingling and numbness (sometimes painful) in hands and feet, dizziness, difficulty writing, nervous system disorders.
- •Increased sensitivity to light, eye disorders.
- •Ringing in the ears (tinnitus).
- •Reduced blood flow in heart vessels, rapid heartbeat.
- •Bleeding, partial or complete blockage of blood vessels, low blood pressure.
- •Shortness of breath, changes in lung tissue, fluid around lungs, throat inflammation, cough, flu-like symptoms.
- •Stomach pain or diarrhea caused by inflammation or ulcers, stomach bleeding, mouth inflammation/ulcers, fluid in the abdomen, vomiting, digestive issues, constipation, gas, bloating, loose stools, abnormal liver enzyme tests, yellowing of skin/eyes due to liver problems, liver damage, and liver inflammation.
- •Itching, rash, hair loss, acne, increased sweating.
- •Joint, limb, back, and foot pain, muscle spasms.
- •Kidney failure, decreased urine production, painful or difficult urination.
- •General weakness, fever, fluid retention in the body, pain and discomfort, increased alkaline phosphatase enzyme in blood, weight gain, feeling of abnormal body temperature.
RARE
- •Changes in blood clotting, decreased number of all blood cells.
- •Dehydration.
- •Decreased blood protein or sugar, increased blood phosphate.
- •Deep unconsciousness (coma), brain hemorrhage, stroke, paralysis, brain disease, speech and language difficulties, memory problems.
- •Clouding of the eye lens (cataract).
- •Impaired hearing.
- •Irregular heartbeats, cardiac arrest, weakened heart, heart muscle disease, enlarged heart muscle, stronger heartbeats, abnormal ECG, abnormal heart rate and pulse.
- •Blood clot in a vein in leg or arm, shock.
- •Respiratory distress, respiratory diseases, asthma.
- •Bowel obstruction, increased amylase in blood, acid reflux, delayed stomach emptying.
- •Dermatitis, burning sensation in skin in sunlight.
- •Joint pain.
- •Urinary incontinence, painful periods and abnormal menstrual bleeding.
- •Multi-organ failure, flu-like symptoms, increased sensitivity to heat and cold, chest pressure, nervousness or abnormal sensations, increased lactate dehydrogenase enzyme in blood, weight loss.
- •Small bleeding in skin due to clotted blood.
- •Increased muscle stiffness.
- •Deafness.
- •Fluid accumulation around the heart.
- •Acute shortness of breath.
- •Cyst formation in the pancreas.
- •Liver blood flow problems.
- •Increased hair growth.
- •Thirst, falls, chest pressure, reduced mobility, ulcers.
- •Muscle weakness.
- •Abnormal results in heart ultrasound (echocardiography).
- •Liver failure, bile duct narrowing.
- •Painful urination with blood in urine.
- •Increased fatty tissue.
- •Rupture in the digestive tract, with strong stomach pain, chills, fever, nausea, or vomiting.
- •The transplanted organ is not working properly.
- •Blurred vision.
- •Damage to small blood vessels (thrombotic microangiopathy), including a condition called hemolytic uremic syndrome with symptoms like low or no urine, extreme tiredness, yellow skin or eyes, and unusual bruising or bleeding.
- •A condition where small blood vessels are damaged, causing fever, red spots under the skin, extreme tiredness, confusion, yellow skin or eyes, kidney problems, vision loss, and seizures.
- •Severe skin reaction with skin damage and blisters, red swollen skin that can peel off widely.
- •Blindness.
- •A severe skin reaction with widespread skin pain, facial swelling, blisters on skin, mouth, eyes and genitals, hives, swollen tongue, and red or purple rash that spreads and peels.
- •Changes in heart rate with chest pain, fainting, dizziness, nausea, palpitations, and breathing difficulties.
- •Long-lasting diarrhea, fever, and sore throat due to infections (bacterial, fungal, viral, parasitic).
- •Benign and malignant tumors (cancers), including skin cancers and a rare cancer called Kaposi's sarcoma, with skin changes like new spots, color changes, or lumps.
- •Severe decrease in red blood cells (pure red cell aplasia) and hemolytic anemia (decreased red blood cells due to abnormal breakdown, with tiredness) and febrile neutropenia (decreased white blood cells that fight infection, with fever). Symptoms can include tiredness, pallor, shortness of breath, dizziness, headache, chest pain, and cold hands/feet.
- •Severe decrease in white blood cells (agranulocytosis) with mouth sores, fever, and infection. Symptoms can include sudden fever, stiffness, and sore throat.
- •Allergic reactions (hives, swelling of hands, feet, ankles, face, lips, mouth or throat making swallowing or breathing difficult) and fainting.
- •Headache, confusion, mood changes, seizures, and vision problems (PRES).
- •Vision problems like blurred vision, color vision changes, difficulty seeing details, or limited visual field (optic neuropathy).
Important Warnings
- Do not use St. John's Wort or other herbal products, as they can change how Adport works.
- Tell your doctor if you have or have had liver problems, as this may affect your Adport dose.
- Contact your doctor immediately if you have severe stomach pain, chills, fever, nausea, vomiting, or diarrhea lasting over one day.
- Inform your doctor about any changes in your heart's electrical activity (QT prolongation).
- Avoid strong sunlight and UV light. Wear protective clothing and high SPF sunscreen, as Adport can increase your risk of skin cancer.
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- Tell your doctor before getting any vaccinations.
- Adport can increase your risk of certain types of cancers (lymphoproliferative disorders) and blood vessel damage. Discuss any concerns with your doctor.
- Tell your doctor if you get fever, bruises under the skin (red spots), extreme tiredness, confusion, yellow skin or eyes, less urine, vision loss, or seizures. These can be signs of small blood vessel damage, which Adport can worsen, especially when taken with sirolimus or everolimus.
- Avoid grapefruit and grapefruit juice while taking Adport.
- Do not use Adport if you are pregnant or breastfeeding, or planning to become pregnant. Adport passes into breast milk.
- Do not drive or use machines if you feel dizzy, sleepy, or have blurred vision after taking Adport. These effects are worse with alcohol.
- If your doctor has told you that you have an intolerance to some sugars (like lactose), talk to them before taking this medicine.
- Do not stop taking Adport without your doctor's advice, as this increases the risk of organ rejection.
- Tell your doctor about all other medicines you are taking, including over-the-counter and herbal remedies, as many can affect Adport. Do not use Adport with ciclosporin.