Zomylac
Zomylac is a combination medicine containing two antibiotics, sulfamethoxazole and trimethoprim, used to treat certain bacterial and fungal infections.
Form
infuusiokonsentraatti, liuosta varten
Strength
80 mg/ml + 16 mg/ml
Active Ingredient
Trimethoprim
Manufacturer
Macure Healthcare Limited
How to Use
Dosage
Adults (over 18 years) typically receive 2 ampoules (5 ml each) in the morning and 2 ampoules (5 ml each) in the evening.
Method
This medicine is given as an infusion directly into a vein, usually if you cannot take medicine by mouth. It is given slowly over a period of time.
Important
The maximum daily dose for adults is 3 ampoules (5 ml each) in the morning and 3 ampoules (5 ml each) in the evening.
Possible Side Effects
COMMON
- •High potassium levels in the blood, which can cause irregular heartbeats, shortness of breath, chest pain, nausea, or vomiting.
- •Fungal infection in the mouth or vagina (thrush or candidiasis).
- •Headache.
- •Nausea.
- •Diarrhea.
- •Rash.
RARE
- •Vomiting.
- •High fever or repeated infections due to low white blood cell count.
- •Low platelet count, which affects blood clotting.
- •High levels of a certain type of white blood cell (eosinophilia).
- •A condition where the blood's ability to carry oxygen is reduced (methemoglobinemia).
- •Enlargement or breakdown of red blood cells.
- •Sudden wheezing or breathing difficulties.
- •Cough.
- •Shortness of breath.
- •Rash or skin redness.
- •Severe allergic reaction (anaphylactic reaction).
- •Potentially life-threatening rashes (Stevens-Johnson syndrome, toxic epidermal necrolysis).
- •Very rare cases of generalized redness over the entire body (acute generalized exanthematous pustulosis, AGEP).
- •Mouth sores, cold sores, and tongue sores or tenderness (stomatiitti).
- •Inflammation of blood vessels (polyarteritis nodosa), sometimes causing purplish rash.
- •Skin lumps or hives with joint swelling and stomach pain (hypersensitivity vasculitis similar to Henoch-Schönlein purpura).
- •Target-like red spots with a darker center, blisters, or scabs (erythema multiforme).
- •Serum sickness, a hypersensitivity reaction with symptoms like rash, fever, and joint pain.
- •Eye inflammation causing pain and redness (uveitis).
- •Rash or sunburn after being outdoors (even on cloudy days).
- •Swelling in deeper skin layers due to fluid buildup (angioedema).
- •Severe skin redness, peeling rash, and crusty skin changes, possibly with fever (exfoliative dermatitis).
- •Low blood sugar (hypoglycemia).
- •Low sodium levels in the blood (hyponatremia).
- •Changes in blood test results.
- •Heart problems caused by infection and/or inflammation (allergic myocarditis).
- •Jaundice (yellowing of skin and whites of eyes), which may occur with unexpected bleeding or bruising.
- •Pancreatitis (inflammation of the pancreas) causing stomach pain, possibly with blood in stool.
- •Tongue inflammation with white spots and swelling (glossitis).
- •Muscle or joint pain (myalgia and arthralgia).
- •Urinary problems like bloody or cloudy urine, increased urine production, and feeling unwell (tubulointerstitial nephritis).
- •Increased blood acidity due to reduced kidney function (renal tubular acidosis).
- •Kidney problems.
- •Connective tissue inflammation (systemic lupus erythematosus).
- •Sudden headache or stiff neck with fever (meningitis).
- •Difficulty controlling movements.
- •Seizures (convulsions or epileptic seizures).
- •Feeling like the world is spinning around you, or that you are spinning (vertigo).
- •Ringing or unusual sounds in the ears (tinnitus).
- •Sharp, stabbing, burning pain in hands or feet, and extreme sensitivity to touch (peripheral neuropathy).
- •Strange or unusual sights or sounds (hallucinations).
- •Depression.
- •Acute inflammation of the lining of the small and large intestines with pseudomembranous plaques and superficial ulcers (pseudomembranous colitis).
- •Breakdown or destruction of liver tissue, which can be life-threatening (hepatic necrosis).
- •Loss of appetite.
- •Acid buildup in the body, causing fast heartbeat, confusion, dizziness, tiredness, loss of appetite, and headache (metabolic acidosis).
- •Psychotic disorders (mental states where touch with reality can be lost).
- •Drug rash with eosinophilia and systemic symptoms (DRESS) (an allergic reaction that can cause fever, skin rash, abnormal blood tests, and liver function test results).
- •Plum-colored, raised, and painful sores on limbs and sometimes on the face and neck, with fever (Sweet's syndrome).
Important Warnings
- Do not use if you are allergic to sulfamethoxazole, trimethoprim, co-trimoxazole, or any other ingredient in this medicine.
- Seek immediate medical help if you develop a severe skin rash, such as Stevens-Johnson syndrome or toxic epidermal necrolysis.
- Do not use if you have severe kidney or liver problems.
- Do not use if you have a history of blood problems like bruising or bleeding (thrombocytopenia) caused by trimethoprim and/or sulfonamides.
- Do not use if you have a rare blood disorder called porphyria.
Show 4 more warnings
- Not for use in newborns under 6 weeks of age.
- Do not use during pregnancy or breastfeeding unless strictly necessary by a doctor; breastfeeding may increase the risk of jaundice in the baby.
- Talk to your doctor if you have alcohol dependency, as this medicine contains ethanol.
- Do not drive or operate machinery if you experience dizziness or fainting while using this medicine.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Contraindicated in case of severe hepatic impairment. Reduce the dose in severe renal impairment. Consider the risks when used in combination with medicines that predispose to hyperkalaemia and are myelotoxic. (updated 6.11.2023)