Zoledronic acid SUN Pharma
This medicine strengthens bones in adults with osteoporosis or Paget's disease, helping to prevent fractures.
Form
infuusioneste, liuos
Strength
5 mg / 100 ml
Active Ingredient
Zoledronic acid monohydrate
Manufacturer
Sun Pharmaceutical Industries Europe B.V.
How to Use
Dosage
A typical dose is 5 mg, given once a year.
Method
It is given as a 15-minute infusion into a vein once a year.
Important
This medicine is given once a year, so there is no daily maximum dose.
Possible Side Effects
COMMON
- •Fever
- •Headache
- •Dizziness
- •Nausea
- •Vomiting
- •Diarrhea
- •Muscle pain
- •Bone and/or joint pain
- •Back, arm, or leg pain
- •Flu-like symptoms (e.g., tiredness, chills, joint and muscle pain)
- •Chills
- •Feeling tired and lacking interest
- •Weakness
- •Pain
- •Feeling unwell
- •Swelling and/or pain at the infusion site
- •Irregular heartbeat (atrial fibrillation)
RARE
- •Swelling, redness, pain, itching, or sensitivity to light in the eyes
- •Ear pain, ear infection, or discharge from the ear, which may be signs of bone damage in the ear
- •Unusual thigh bone fractures
- •Low phosphate levels in the blood
- •Pain in the mouth and/or jaw, swelling, non-healing sores in the mouth or jaw, pus from sores, numbness or heavy feeling in the jaw, or loose teeth. These can be signs of jawbone damage (osteonecrosis).
- •Severe allergic reaction, including dizziness and difficulty breathing, swelling mainly in the face and throat, low blood pressure, dehydration related to acute phase reactions (symptoms such as fever, vomiting, and diarrhea after dosing).
- •Kidney problems (e.g., reduced urine output).
- •Flu
- •Upper respiratory infections
- •Reduced red blood cells
- •Loss of appetite
- •Insomnia
- •Drowsiness, possibly with reduced alertness and awareness
- •Tingling or numbness
- •Extreme tiredness
- •Tremors
- •Temporary loss of consciousness
- •Eye infection or painful/red irritation and inflammation
- •Vertigo
- •High blood pressure
- •Flushing
- •Cough
- •Shortness of breath
- •Indigestion
- •Abdominal pain
- •Constipation
- •Dry mouth
- •Heartburn
- •Rash
- •Heavy sweating
- •Itching
- •Red skin
- •Neck pain
- •Stiffness in muscles, bones, and/or joints
- •Joint swelling
- •Muscle cramps
- •Shoulder pain
- •Chest muscle or chest pain
- •Arthritis
- •Muscle weakness
- •Abnormal kidney function test results
- •Frequent urination
- •Swelling in hands, ankles, and feet
- •Thirst
- •Toothache
- •Taste disturbances
Important Warnings
- Do not take if you are allergic to zoledronic acid, other bisphosphonates, or any ingredients in this medicine.
- Do not take if you have very low calcium levels in your blood.
- Do not take if you have severe kidney problems.
- Do not take if you are pregnant, planning to become pregnant, or breastfeeding.
- Tell your doctor if you have jaw pain, swelling, non-healing sores in your mouth, or loose teeth. This could be a sign of a serious jawbone problem.
Show 3 more warnings
- Your doctor will check your kidney function with blood tests before each dose. Drink at least 2 glasses of water a few hours before your infusion to prevent dehydration.
- Take calcium and vitamin D supplements as directed by your doctor.
- Do not drive or use machines if you feel dizzy after treatment.