Zofran Zydis
Zofran Zydis is a medicine that helps stop you from feeling sick (nausea) and throwing up (vomiting) after cancer treatment or surgery.
How to Use
Dosage
Your doctor will tell you the exact dose. For nausea from cancer treatment, adults usually take 8 mg twice a day for up to 5 days, starting with a dose before treatment. Children's dose is decided by the doctor, but should not be more than 8 mg per day for up to 5 days. For nausea after surgery, adults usually take 4-8 mg one hour before the operation.
Method
Do not push the tablet through the foil. Peel back the foil in the direction of the arrow and gently push out the tablet. Place the tablet on your tongue where it will quickly dissolve. Then swallow as usual.
For adults, the maximum daily dose for cancer treatment is usually 16 mg. For children, the maximum daily dose for cancer treatment is 8 mg. For adults preventing nausea after surgery, the maximum single dose is 8 mg. Do not take more than your doctor prescribes. If you vomit within one hour of taking a tablet, take the same dose again, but do not exceed the total daily dose prescribed by your doctor.
Possible Side Effects
- •Headache
- •Warm feeling or flushing
- •Constipation
- •Convulsions or seizures
- •Problems with movement
- •Irregular or slow heartbeat (arrhythmia)
- •Chest pain
- •Low blood pressure
- •Hiccups
- •Increased liver enzyme levels (shown in blood tests, usually with no symptoms)
- •Temporary blurred vision or other vision problems
- •Temporary loss of vision
- •Widespread rash with blisters and peeling skin (toxic epidermal necrolysis)
Important Warnings
- Do not take Zofran Zydis if you are taking apomorphine, a medicine for Parkinson's disease.
- Tell your doctor if you are allergic to ondansetron or any other ingredient in Zofran Zydis, or to similar medicines like granisetron or palonosetron.
- Talk to your doctor if you have ever had heart problems, like an irregular heartbeat.
- Talk to your doctor if you have problems with your bowels (intestines).
- Talk to your doctor if you have liver disease, as your doctor might need to lower your dose.
Show 6 more warnings
- Do not use Zofran Zydis during the first three months of pregnancy, as it may slightly increase the risk of your baby being born with a cleft lip and/or palate. If you are pregnant, think you might be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Women who can get pregnant should use effective birth control.
- It is not recommended to breastfeed while taking Zofran Zydis because the medicine's ingredients can pass into breast milk and affect your baby.
- Stop taking Zofran Zydis and get immediate medical help if you experience a severe allergic reaction (signs include raised, itchy rash, swelling of the face or mouth causing breathing difficulties, or fainting).
- Seek immediate medical attention if you experience sudden chest pain or a tight feeling in your chest.
- This medicine contains aspartame. If you have phenylketonuria (PKU), talk to your doctor.
- This medicine contains benzyl alcohol. Do not give it to newborns (up to 4 weeks old) or use for more than one week in children under 3 years unless directed by a doctor. If you are pregnant or breastfeeding, or have liver or kidney problems, ask your doctor or pharmacist for advice as large amounts of benzyl alcohol can build up in the body and cause side effects.
Use in Elderly Patients
Suitable for older adults, with specific cautions. May prolong the QT interval especially with other preparations prolonging QT. Take interactions into account. (updated 20.5.2024)