•Abnormal periods (heavy, light, infrequent, or absent), breakthrough bleeding, painful periods, breast swelling
•Tiredness, weakness, general discomfort, weight gain
•Blood clots (in legs, lungs, heart, brain, or other organs)
•Allergic reactions
•Mood swings, changes in sex drive, hives, fluid retention
Important Warnings
Do not use if you have or have had a blood clot in your legs, lungs, or other parts of your body. Seek immediate medical help if you notice symptoms of a blood clot, such as leg swelling or sudden shortness of breath.
Tell your doctor if you are going to have surgery or will be on prolonged bed rest.
Do not use if you have ever had a heart attack or stroke.
Do not use if you have severe diabetes, very high blood pressure, very high levels of fat in your blood, or certain types of migraine with aura.
Do not use if you have severe liver disease or a liver tumor.
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Do not use if you have a cancer affected by sex hormones, such as breast or cervical cancer.
Do not use if you have unexplained vaginal bleeding.
Do not use if you are allergic to ethinylestradiol, dienogest, or any other ingredients in Yanulez.
Do not use if you have Hepatitis C and are taking certain medications for it (e.g., combinations of ombitasvir/paritaprevir/ritonavir and dasabuvir, or glecaprevir/pibrentasvir, or sofosbuvir/velpatasvir/voxilaprevir).
Contact a doctor immediately if you develop symptoms of angioedema, such as swelling of the face, tongue, or throat, difficulty swallowing, or hives with breathing difficulties.
If you experience mood changes or symptoms of depression, contact your doctor.