Vortioxetine Krka
Vortioxetine Krka is an antidepressant medication used to treat major depression in adults, helping to ease symptoms like sadness and anxiety.
Form
tabletti, kalvopäällysteinen
Strength
15 mg
Active Ingredient
Vortioxetine hydrobromide
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
For adults under 65, the usual dose is 10 mg once daily. Your doctor may adjust it between 5 mg and 20 mg daily. For those 65 and older, the starting dose is 5 mg once daily.
Method
Take one tablet with a glass of water. You can take it with or without food.
Important
The maximum daily dose is 20 mg, and the minimum is 5 mg.
Possible Side Effects
COMMON
- •Nausea
- •Diarrhea
- •Constipation
- •Vomiting
- •Dizziness
- •Itching all over the body
- •Abnormal dreams
- •Increased sweating
- •Indigestion
RARE
- •Redness of the skin
- •Night sweats
- •Blurred vision
- •Involuntary tremors
- •Hallucinations (seeing, hearing, or feeling things that are not there)
- •Dilated pupils (mydriasis), which may increase the risk of glaucoma.
- •Low blood sodium (salt) levels, which can cause dizziness, weakness, confusion, sleepiness, severe tiredness, or feeling sick. More serious signs include fainting, seizures, or falls.
- •Serotonin syndrome (a serious condition with symptoms like seeing or hearing things that aren't there, fast heartbeat, high blood pressure, fever, and severe stomach issues).
- •Severe allergic reactions (swelling of face, lips, tongue or throat, breathing/swallowing difficulties, sudden drop in blood pressure).
- •Hives (itchy skin rash).
- •Excessive or unexplained bleeding (including bruising, nosebleeds, stomach/gut, and vaginal bleeding).
- •Skin rash
- •Sleep disorders (insomnia or trouble sleeping)
- •Agitation and aggression. If these occur, contact your doctor.
- •Headache
- •Increased levels of prolactin (a hormone) in the blood.
- •Constant need to move (akathisia)
- •Teeth grinding (bruxism)
- •Inability to open mouth (lockjaw/trismus)
- •Restless legs syndrome (an irresistible urge to move legs, often at night, to stop painful or strange sensations).
- •Abnormal milk secretion from the breast (galactorrhea).
- •Increased risk of bone fractures.
- •Increased risk of sexual dysfunction.
- •Abdominal pain (more common in children and adolescents).
- •Suicidal thoughts (more common in children and adolescents).
Important Warnings
- Do not take if you are allergic to vortioxetine or any other ingredient in this medicine.
- Do not take Vortioxetine Krka if you are taking certain other antidepressants called MAOIs. You must wait 14 days after stopping an MAOI before starting Vortioxetine Krka, and 14 days after stopping Vortioxetine Krka before starting an MAOI.
- Tell your doctor if you take other medicines that affect serotonin, such as strong painkillers (e.g., tramadol) or migraine medicines (e.g., sumatriptan). Taking them with Vortioxetine Krka can lead to serotonin syndrome, causing symptoms like confusion, muscle twitching, fast heartbeat, high blood pressure, fever, nausea, or diarrhea.
- Tell your doctor if you have had seizures or have epilepsy, as this medicine might increase the risk. Treatment should be stopped if seizures occur or get worse.
- Tell your doctor if you have had mania (a period of extreme high mood or energy).
Show 12 more warnings
- Tell your doctor if you easily bleed or bruise, or if you are pregnant, as this medicine might increase the risk of bleeding.
- Tell your doctor if you have low blood sodium (salt) levels.
- If you are 65 years or older, tell your doctor.
- Tell your doctor if you have severe kidney or liver disease.
- Tell your doctor if you have or have had high eye pressure or glaucoma. Contact your doctor if you experience eye pain or blurred vision during treatment.
- If you feel aggressive, agitated, angry, or irritable during treatment, contact your doctor.
- If you have suicidal thoughts or thoughts of harming yourself, contact your doctor immediately or go to a hospital. This risk may increase at the start of treatment, especially if you are a young adult or have had such thoughts before.
- If you are pregnant, think you might be pregnant, or are planning a baby, ask your doctor for advice. Vortioxetine Krka should not be used during pregnancy unless absolutely necessary.
- Using this medicine in the last 3 months of pregnancy can cause serious problems for the newborn like breathing difficulties, blue skin, seizures, or feeding problems. It can also increase the risk of a lung problem called PPHN. Contact your doctor or midwife immediately if your baby shows any such symptoms.
- Taking Vortioxetine Krka late in pregnancy may increase the risk of heavy vaginal bleeding after birth, especially if you have had bleeding problems before. Inform your doctor or midwife.
- Do not use Vortioxetine Krka while breastfeeding, as its ingredients may pass into breast milk.
- Be cautious when driving or operating machines, especially at the start of treatment or when your dose changes, as dizziness has been reported.