Triptyl
Triptyl is a medicine used to treat depression, nerve pain, certain types of headaches, and bedwetting.
Form
tabletti, kalvopäällysteinen
Strength
10 mg
Active Ingredient
Amitriptyline hydrochloride
Manufacturer
Orion Corporation
How to Use
Dosage
For adults with depression, the usual starting dose is 25 mg twice a day; your doctor may slowly increase it up to 150 mg per day, split into two doses.
Method
Take this medicine with or without food; swallow the tablets whole with some water, do not chew them.
Important
The maximum daily dose for adults is generally 150 mg, but your doctor will decide the right dose for you.
Possible Side Effects
COMMON
- •Drowsiness or sleepiness
- •Shaking in hands or other body parts
- •Dizziness
- •Headache
- •Irregular, strong, or fast heartbeat
- •Dizziness when standing up due to low blood pressure
- •Dry mouth
- •Constipation
- •Nausea (feeling sick)
- •Heavy sweating
- •Weight gain
- •Slurred or slow speech
- •Aggression
- •Stuffy nose
- •Confusion
- •Sexual changes (like reduced sex drive, problems with erection)
- •Problems with paying attention
- •Changes in taste
- •Numbness or tingling in arms and legs
- •Problems with coordination
- •Large pupils
- •Heart block (a type of irregular heartbeat)
- •Tiredness
- •Low sodium levels in the blood
- •Restlessness or agitation
- •Problems with urination
- •Thirst
RARE
- •Excitement, anxiety, trouble sleeping, nightmares
- •Seizures
- •Ringing in the ears
- •High blood pressure
- •Diarrhea, vomiting
- •Rash, hives, swelling of the face and tongue
- •Difficulty urinating
- •Increased breast milk production or discharge (not related to breastfeeding)
- •Increased eye pressure
- •Dizziness and fainting spells
- •Worsening heart failure
- •Reduced liver function (e.g., cholestatic liver disease)
- •Decreased appetite
- •Delirium (a state of confusion or loss of touch with reality, especially in older patients), hallucinations
- •Abnormal heart rhythm or irregular heartbeat
- •Swollen salivary glands
- •Hair loss
- •Increased sensitivity to sunlight
- •Breast enlargement in men
- •Fever
- •Weight loss
- •Abnormal liver function tests
- •Heart muscle disease
- •Feeling restless and needing to move constantly
- •Nerve problems (like numbness or tingling in arms and legs, changes in feeling)
- •Sudden increase in eye pressure
- •Specific types of abnormal heart rhythm (e.g., Torsades de Pointes)
- •Allergic inflammation in the lungs
- •Increased or decreased blood sugar levels
- •Paranoia (false beliefs)
- •Movement problems (uncontrolled or reduced movements)
- •Heart muscle inflammation due to an allergic reaction
- •Liver inflammation
- •Hot flushes
- •Dry eyes
Important Warnings
- Do not take this medicine if you are allergic to amitriptyline or any other ingredient in it.
- Do not take this medicine if you have recently had a heart attack or have heart problems such as an irregular heartbeat, heart block, or coronary artery disease.
- Do not take this medicine if you are currently taking or have taken MAOI inhibitors (a type of antidepressant) in the last 14 days, or moclobemide the day before.
- Do not take this medicine if you have severe liver disease.
- This medicine should not be given to children under 6 years of age.
Show 4 more warnings
- Tell your doctor if you have a slow heart rate or other heart issues, as Triptyl can affect heart rhythm, visible on an ECG as "QT prolongation".
- If you are depressed and have thoughts of harming yourself, talk to your doctor immediately or go to a hospital; this is especially important for young adults under 25.
- Stop taking Triptyl and see a doctor right away if you get a widespread rash, fever, and swollen lymph nodes (a severe allergic reaction called DRESS syndrome).
- This medicine can make you sleepy or dizzy, especially at the start of treatment; do not drive or use machines if you feel this way.
Use in Elderly Patients
Category D
Avoid use in older adults. Anticholinergic. Sedative. Serotonergic. Risk of QT prolongation. Significant adverse effects include confusion, cognitive impairment, arrhythmias and orthostatic hypotension. Increases risk of falls. Consider the numerous potential interactions. Reduces the effectiveness of drugs for Alzheimer’s disease. (updated 12.2.2024)