Triplixam
Triplixam is a triple combination medicine that lowers high blood pressure.
Form
tabletti, kalvopäällysteinen
Strength
5 mg / 1.25 mg / 5 mg
Active Ingredient
Perindopril arginine
Manufacturer
Les Laboratoires Servier
How to Use
Dosage
One tablet once a day.
Method
Take the tablet with a glass of water in the morning before a meal.
Important
Do not exceed one tablet per day, unless your doctor tells you otherwise.
Possible Side Effects
COMMON
- •Swelling (fluid retention)
- •Headache
- •Dizziness or feeling light-headed
- •Feeling your heartbeat (palpitations)
- •Red face or neck (flushing)
- •Spinning sensation (vertigo)
- •Tingling or numbness
- •Blurred or double vision
- •Ringing in the ears (tinnitus)
- •Feeling unreal or detached, due to low blood pressure
- •Cough
- •Shortness of breath
- •Stomach upset, like nausea, vomiting, stomach pain, indigestion, diarrhea, or constipation
- •Changes in taste
- •Allergic skin reactions, like rash or itching
- •Muscle spasms
- •Feeling tired, weak, or sleepy
- •Swelling of the ankles
- •Low potassium level in the blood
- •Severe dizziness or fainting
RARE
- •Sudden wheezing, chest pain, or serious breathing problems
- •Swelling of the eyelids, face, lips, mouth, tongue, or throat that causes major breathing trouble
- •Severe skin reactions like bad rash, hives, redness, intense itching, blisters, skin peeling, or swelling (e.g., Stevens-Johnson syndrome)
- •Heart attack or a dangerous irregular heartbeat
- •Pancreatitis (inflammation of the pancreas), causing severe stomach and back pain, and feeling very sick
- •Muscle weakness, cramps, tenderness, or pain, especially with fever (could be due to muscle breakdown)
- •Mood changes, anxiety, depression, or sleep problems
- •Trembling, fainting, or loss of sensation to pain
- •Irregular or fast heartbeat
- •Blocked or runny nose
- •Hair loss
- •Purple spots on the skin (purpura) or skin discoloration
- •Sweating, chest pain, or joint/muscle/back pain
- •General feeling of being unwell, kidney problems, trouble urinating, or needing to urinate more often at night
- •Problems with erections (impotence)
- •Fever or discomfort/enlargement of male breasts
- •Weight gain or loss
- •Changes in blood tests like increased white blood cells, high potassium, low blood sugar, low sodium (leading to dehydration/low blood pressure)
- •Inflammation of blood vessels (vasculitis)
- •Skin reactions when exposed to sunlight or artificial UV light
- •Clusters of blisters on the skin, or swelling of hands, ankles, or feet
- •Increased creatinine and urea in blood tests
- •Falls or dry mouth
- •Confusion
- •Other blood test changes like low chloride, low magnesium, high liver enzymes, or high bilirubin
- •Worsening of psoriasis, flushing, or greatly reduced urine output/kidney failure
- •Dark urine, nausea/vomiting, muscle cramps, confusion, and seizures (symptoms of SIADH)
- •Low white blood cells, low platelets (easy bruising/nosebleeds), or low red blood cells (anemia)
- •Angina (chest pain with exertion) or a rare type of lung inflammation (eosinophilic pneumonia)
- •Swollen, tender, or thickened gums, or bleeding
- •Liver problems like inflammation (hepatitis) or yellowing of the skin/eyes (jaundice)
- •Stomach inflammation (gastritis)
- •Nerve problems causing weakness, tingling, or numbness, or severe muscle stiffness
- •High blood sugar or high calcium in the blood
- •Stroke, possibly caused by very low blood pressure
- •Brain problems due to liver disease (hepatic encephalopathy)
- •Abnormal heart test (ECG) results
- •Nearsightedness, blurred vision, or eye pain due to high eye pressure (fluid buildup or glaucoma)
- •Trembling, stiff posture, expressionless face, slow movements, shuffling walk, discolored/numb/painful fingers or toes (Raynaud's phenomenon)
Important Warnings
- Do not take this medicine if you are allergic to any of its ingredients.
- Stop immediately and call your doctor if you get sudden swelling in your face, lips, tongue, or throat, making it hard to breathe or swallow.
- Do not use this medicine if you are pregnant (especially over 3 months) or breastfeeding. Talk to your doctor if you plan to become pregnant.
- Do not take if you have severe liver or kidney disease, or if you are on dialysis.
- Do not take if you have very low blood pressure.
Show 8 more warnings
- Do not take if you have diabetes or kidney problems and are taking a medicine containing aliskiren.
- Do not use at the same time as a heart failure medicine containing sacubitril and valsartan.
- Tell your doctor if you get eye pain or worsening eyesight.
- Athletes should know that this medicine can cause a positive doping test result.
- This medicine must not be given to children or adolescents.
- Do not eat grapefruit or drink grapefruit juice while taking this medicine.
- Tell your doctor if you are taking other blood pressure medicines or medicines that raise potassium (e.g., lithium, potassium-sparing diuretics).
- Tell your doctor or dentist if you are going to have anesthesia or surgery.
Use in Elderly Patients
Category A
Suitable for older adults. Significant adverse effects include ankle oedema and orthostatic hypotension. Consider potential interactions. Avoid grapefruit. (updated 17.2.2025)