Tramadol Retard Hexal
This medicine is a pain reliever for moderate to severe pain. It works in your brain and spinal cord to reduce pain signals.
Form
depottabletti
Strength
100 mg
Active Ingredient
Tramadol hydrochloride
Manufacturer
Hexal A/S
How to Use
Dosage
Take one 100 mg tablet twice a day, usually in the morning and evening. Your doctor may increase the dose to 150 mg or 200 mg twice daily if needed.
Method
Swallow the tablets whole with enough liquid, like a glass of water. Do not break, crush, or chew them. You can take them with or without food.
Important
Always wait at least 8 hours between doses. Do not take more than 400 mg per day, unless your doctor tells you otherwise.
Possible Side Effects
COMMON
- •Nausea
- •Dizziness
- •Headache
- •Drowsiness
- •Fatigue
- •Vomiting
- •Constipation
- •Dry mouth
- •Sweating
RARE
- •Allergic reactions (e.g., swelling, difficulty breathing)
- •Effects on blood circulation (e.g., fast heartbeat, weakness, low blood pressure when standing)
- •Stomach problems (e.g., pain, bloating, diarrhea, gagging)
- •Skin reactions (e.g., itching, rash, sudden redness)
- •Mental changes (e.g., hallucinations, confusion, anxiety, sleep issues, mood changes)
- •Drug dependence or addiction
- •Appetite changes
- •Strange skin feelings (e.g., tingling, numbness)
- •Shaking (tremor)
- •Shallow or slow breathing
- •Seizures
- •Involuntary muscle twitching or weakness
- •Fainting or coordination problems
- •Vision problems (e.g., blurred vision, pupil changes)
- •Heart rate or blood pressure changes
- •Difficulty urinating or reduced urine output
- •Increased liver enzymes
- •Serotonin syndrome (a serious condition with symptoms like restlessness, fever, fast heart rate, muscle stiffness, nausea, diarrhea)
- •Low blood sugar
- •Hiccups
Important Warnings
- Do not take this medicine if you are allergic to tramadol or any other ingredients. Seek immediate medical help if you have signs of an allergic reaction like swelling of the face, tongue, or throat, or difficulty breathing.
- Do not use if you are intoxicated by alcohol, sleeping pills, other strong pain medicines (opioids), or medicines that affect your mood or emotions.
- Do not use if you are taking or have taken MAO inhibitors (for depression or Parkinson's disease) in the last 14 days.
- Do not use if you have epilepsy and your seizures are not well controlled by treatment.
- Do not use as a substitute for drug withdrawal treatment.
Show 16 more warnings
- Tell your doctor if you think you are already dependent on other opioid pain relievers.
- Tell your doctor if you have reduced consciousness (e.g., feel dizzy or dazed) or are in shock (cold sweat can be a sign).
- Tell your doctor if you have breathing problems or sleep-related breathing issues (like stopping breathing during sleep, waking up due to shortness of breath, or feeling very sleepy during the day).
- Tell your doctor if you have increased pressure in your brain (e.g., after a head injury or with brain diseases).
- Tell your doctor if you have liver or kidney problems. Do not take if you have severe liver or kidney failure; for mild to moderate problems, your doctor might adjust your dose.
- Tell your doctor if you are sensitive to opioids.
- Tell your doctor if you have a history of epilepsy or seizures.
- Tell your doctor if you have depression or take antidepressants, as there's a small risk of a serious condition called serotonin syndrome. Seek immediate medical help if you experience symptoms like confusion, agitation, fever, sweating, fast heart rate, muscle twitching, or severe diarrhea.
- Contact your doctor if you experience severe tiredness, loss of appetite, severe stomach pain, nausea, vomiting, or low blood pressure, as these could be signs of adrenal insufficiency.
- This medicine is not for children under 12 years old, especially those with breathing problems, as side effects can be more severe.
- If you are over 75, your doctor may recommend longer breaks between doses because the medicine might stay in your body longer.
- Avoid alcohol and tell your doctor if you take other medicines that slow down brain function (like other strong pain relievers, cough medicines), as this can cause severe drowsiness or dizziness.
- Tell your doctor if you take blood-thinning medicines (like warfarin), as this medicine can increase the risk of bleeding.
- Using this medicine with sedatives (like sleeping pills or anti-anxiety drugs) can cause severe drowsiness, breathing problems, or coma, which can be life-threatening. Tell your doctor about all sedatives you take.
- This medicine can make you drowsy, dizzy, or blur your vision, affecting your ability to react. Do not drive or use machines if you feel these effects.
- This medicine contains an opioid, which can lead to dependence, misuse, and addiction if used repeatedly, especially with higher doses or longer use. This risk is higher if you or your family have a history of alcohol or drug abuse, if you smoke, or have a history of mood problems or other mental health issues.
Use in Elderly Patients
Category D
Avoid use in older adults. Serotonergic. Prodrug. Genotype affects the response. Reduce the dose in moderately severe and severe renal impairment. Increases the risk of confusion and falling. Need for laxative is often necessary. Consider potential interactions. (updated 18.8.2025)