Tostran
Tostran is a testosterone hormone gel for adult men to treat health problems caused by low testosterone levels.
Form
transdermaaligeeli
Strength
20 mg/g
Active Ingredient
Testosterone
Manufacturer
Advanz Pharma Limited
How to Use
Dosage
The usual starting dose is 3 grams of gel (60 mg testosterone) per day.
Method
Apply the gel once a day at the same time, such as in the morning after a shower, to clean, dry, healthy skin. Rub it gently onto your abdomen or the inner part of both thighs until it dries. Do not apply to other areas or genitals. Cover the area with clothes once dry and wash your hands well with soap and water.
Important
The maximum daily dose is 4 grams of gel (80 mg testosterone).
Possible Side Effects
COMMON
- •Skin reactions where gel is applied (burning, stinging, dryness, rash, redness, itching)
RARE
- •Swelling of hands or feet
- •High blood pressure
- •Prostate changes (including higher PSA levels)
- •Increased body hair
- •Breast enlargement
- •Increase in red blood cells, hematocrit, and hemoglobin (seen in blood tests)
- •Hair loss, dandruff, acne
- •Liver problems (jaundice, abnormal tests)
- •Nausea, changes in sex drive, more erections
- •Trouble urinating, feeling sad or nervous, hostility
- •Weight gain, muscle cramps or pain
- •Fluid retention, swollen ankles, sleep apnea
- •Painful or long-lasting erections (rare), decreased sperm production/testicle size (high doses), changes in salt levels
- •High blood sugar (hyperglycemia)
Important Warnings
- Do not use if you are allergic to testosterone or any other ingredient, or if you have or might have breast or prostate cancer.
- If you have severe heart, liver, or kidney problems, Tostran can cause serious issues like fluid build-up in your body.
- Tell your doctor if you have high blood pressure, as testosterone can increase it.
- Testosterone treatment may increase the risk of an enlarged prostate or prostate cancer.
- Tell your doctor if you have swollen hands/feet, are overweight or have a chronic lung disease (Tostran can worsen sleep apnea), have diabetes (Tostran can affect insulin), have epilepsy or migraine (can worsen conditions), have bone cancer (calcium levels need checking), or have blood clotting problems (thrombophilia or risk factors like past clots, smoking, obesity, cancer, immobility, or family history of clots).
Show 8 more warnings
- Contact your doctor if you have frequent or long-lasting erections, feel irritable, nervous, gain weight, have nausea, vomiting, skin color changes, swollen ankles, or breathing changes during sleep. These could mean your dose is too high.
- Athletes should note that Tostran contains testosterone, which can cause positive doping test results.
- Tostran should not be used for male infertility or impotence treatment.
- Women should not use Tostran as it can cause male features like increased hair, deeper voice, or menstrual changes.
- Tostran can transfer to others through skin contact, causing male features in women (e.g., hair growth, deeper voice) or early puberty in children. Cover the application area with clothes and wash it before contact to reduce this risk.
- Contact your doctor if untreated individuals (like your partner or children) show signs of male features, such as increased hair or severe acne.
- Inform your doctor or pharmacist about any other medications you are taking, especially blood thinners or corticosteroids.
- Pregnant or breastfeeding women must not use Tostran. Pregnant women must avoid any skin contact with Tostran, as it can harm or cause birth defects in the unborn baby.
Use in Elderly Patients
Category D
Avoid use in older adults. Start and continue therapy under specialist supervision. Consider risk of cardiovascular adverse effects and possibility of mental disorders. (updated 21.10.2024)