Thiotepa Fresenius Kabi
This medicine helps prepare for bone marrow transplant by destroying old bone marrow cells, allowing new healthy cells to be transplanted.
Form
kuiva-aine välikonsentraatiksi infuusionestettä varten, liuos
Strength
100 mg
Active Ingredient
Thiotepa
Manufacturer
Fresenius Kabi AB
How to Use
Dosage
Your doctor will calculate your dose based on your body surface area or weight and your condition.
Method
The medicine is given as a drip into a vein (infusion) after dilution, and the infusion takes 2–4 hours.
Important
Your doctor will determine the maximum daily amount, and treatment can last up to five days.
Possible Side Effects
COMMON
- •Increased risk of infection
- •Body-wide inflammation (sepsis)
- •Decrease in white blood cells, platelets, and red blood cells (anemia)
- •Transplanted cells attacking your body (graft-versus-host disease)
- •Dizziness, headache, blurred vision
- •Uncontrolled body shaking (seizures)
- •Tingling, prickling, or numbness (paresthesia)
- •Partial loss of movement ability
- •Cardiac arrest
- •Nausea, vomiting, diarrhea
- •Inflammation of mouth lining (mucositis)
- •Irritated stomach, esophagus, intestine
- •Colon inflammation
- •Loss of appetite
- •High blood sugar
- •Rash, itching, peeling skin
- •Skin color changes (not jaundice)
- •Skin redness (erythema)
- •Hair loss
- •Back and abdominal pain, general pain
- •Muscle and joint pain
- •Abnormal heart rhythm (arrhythmias)
- •Lung tissue inflammation
- •Enlarged liver
- •Changes in organ function
- •Liver vein blockage (veno-occlusive liver disease)
- •Yellowing of skin and eyes (jaundice)
- •Hearing loss
- •Lymphatic blockage
- •High blood pressure
- •Increased liver, kidney, and digestive enzyme levels
- •Abnormal blood electrolyte levels
- •Weight gain
- •Fever, general weakness, chills
- •Bleeding
- •Nosebleed
- •General swelling due to fluid retention (edema)
- •Pain or inflammation at the infusion site
- •Eye inflammation (conjunctivitis)
- •Decreased sperm count
- •Vaginal bleeding
- •Absence of menstruation (amenorrhea)
- •Memory loss
- •Delayed weight gain and growth
- •Bladder dysfunction
- •Low testosterone production
- •Low thyroid hormone production
- •Pituitary gland underactivity
- •Confusion
RARE
- •Anxiety
- •Abnormal bulging of an artery in the brain (intracranial aneurysm)
- •Increased creatinine levels
- •Allergic reactions
- •Blood clot (embolism)
- •Heart rhythm disorders
- •Heart failure
- •Cardiovascular failure
- •Lack of oxygen
- •Fluid accumulation in the lungs (pulmonary edema)
- •Lung bleeding
- •Respiratory arrest
- •Blood in urine (hematuria) and moderate kidney impairment
- •Bladder inflammation
- •Discomfort during urination and decreased urine output (dysuria and oliguria)
- •Increased nitrogen compounds in the blood (increased BUN)
- •Cataracts
- •Liver failure
- •Brain hemorrhage
- •Cough
- •Constipation and stomach problems
- •Bowel obstruction
- •Stomach perforation
- •Changes in muscle tone
- •Severely reduced muscle coordination
- •Bruises due to low platelet count
- •Menopausal symptoms
- •Cancer (secondary primary cancer)
- •Abnormal brain function
- •Male and female infertility
- •Skin inflammation and peeling (erythrodermic psoriasis)
- •Delirium, nervousness, hallucinations, agitation
- •Stomach/intestinal ulcer
- •Inflammation of heart muscle (myocarditis)
- •Heart disease (cardiomyopathy)
- •Elevated blood pressure in lung arteries (pulmonary arterial hypertension)
- •Severe skin damage (life-threatening)
- •Damage to part of the brain (life-threatening leukoencephalopathy)
Important Warnings
- Do not use if you are allergic to thiotepa.
- Do not use if you are pregnant or think you might be pregnant.
- Do not use if you are breastfeeding.
- Avoid yellow fever vaccine or live virus/bacteria vaccines.
- Tell your doctor if you have liver or kidney problems.
Show 4 more warnings
- Tell your doctor if you have heart or lung problems.
- Tell your doctor if you have had seizures or epilepsy.
- This medicine may increase the risk of other cancers later; discuss this with your doctor.
- Some side effects like dizziness, headache, or blurred vision can affect driving and using machines. Do not drive or operate machinery if you have these symptoms.