Thiotepa Fresenius Kabi
Thiotepa Fresenius Kabi is a medicine used as a preparatory treatment before a bone marrow transplant, by destroying old bone marrow cells to allow new, healthy blood cells to form.
Form
kuiva-aine välikonsentraatiksi infuusionestettä varten, liuos
Strength
15 mg
Active Ingredient
Thiotepa
Manufacturer
Fresenius Kabi AB
How to Use
Dosage
Your doctor will calculate your dose based on your body surface area or weight and your disease.
Method
Thiotepa Fresenius Kabi is given as an intravenous infusion (drip into a vein) after the medicine has been diluted. Each infusion lasts 2-4 hours.
Important
Treatment can last up to five days, with infusions given every 12 or 24 hours.
Possible Side Effects
COMMON
- •Increased risk of infections
- •Sepsis (severe body infection)
- •Decreased number of white blood cells, platelets, and red blood cells (anemia)
- •Graft-versus-host disease (transplanted cells attacking your body)
- •Dizziness, headache, blurred vision
- •Uncontrolled body trembling (convulsions)
- •Tingling, pricking, or numbness (paresthesia)
- •Partial loss of movement
- •Cardiac arrest
- •Nausea, vomiting, diarrhea
- •Inflammation of mouth lining (mucositis)
- •Irritated stomach, esophagus, or bowel
- •Colon inflammation
- •Loss of appetite
- •High blood sugar levels
- •Rash, itching, flaking skin
- •Skin discoloration (not jaundice)
- •Skin redness (erythema)
- •Hair loss
- •Back and abdominal pain
- •Muscle and joint pain
- •Abnormal heart rhythm (arrhythmia)
- •Lung tissue inflammation
- •Enlarged liver
- •Altered organ function
- •Blockage of a liver vein (veno-occlusive liver disease)
- •Yellowing of skin and eyes (jaundice)
- •Hearing loss
- •Blocked lymph nodes
- •High blood pressure
- •Elevated liver, kidney, and digestive enzyme levels
- •Abnormal blood electrolyte levels
- •Weight gain
- •Fever, general weakness, chills
- •Bleeding
- •Nosebleeds
- •Swelling due to fluid retention (edema)
- •Pain or inflammation at the injection site
- •Eye inflammation (conjunctivitis)
- •Decreased sperm count
- •Vaginal bleeding
- •Absence of menstruation (amenorrhea)
- •Memory loss
- •Delayed weight gain and growth
- •Bladder problems
- •Low testosterone production
- •Low thyroid hormone production
- •Pituitary gland problems
- •Confusion
- •Anxiety, confusion
- •Abnormal bulging of brain arteries (intracranial aneurysm)
- •Elevated creatinine levels
- •Allergic reactions
- •Blood clot in a blood vessel
- •Heart rhythm disturbances
- •Heart failure
- •Cardiovascular failure
- •Lack of oxygen
- •Fluid in the lungs (pulmonary edema)
- •Lung bleeding
- •Respiratory arrest
- •Blood in urine (hematuria) and moderate kidney failure
- •Bladder inflammation
- •Painful urination and decreased urine output (dysuria and oliguria)
- •Increased nitrogenous compounds in blood
- •Cataracts
- •Liver failure
- •Brain hemorrhage
- •Cough
- •Constipation and stomach discomfort
- •Bowel obstruction
- •Stomach perforation
- •Changes in muscle tone
- •Severe lack of muscle coordination
- •Bruising due to low platelet count
- •Menopausal symptoms
- •Cancer (second primary cancer)
- •Abnormal brain function
- •Male and female infertility
RARE
- •Skin inflammation and peeling (erythrodermic psoriasis)
- •Confusion, nervousness, hallucinations, agitation
- •Gastrointestinal ulcer
- •Inflammation of heart muscle (myocarditis)
- •Abnormal heart condition (cardiomyopathy)
- •High blood pressure in lung arteries (pulmonary arterial hypertension)
- •Severe, life-threatening skin damage (e.g., severe lesions, blisters) covering the entire body
- •Life-threatening brain damage (leukoencephalopathy)
Important Warnings
- Do not use if you are allergic to thiotepa.
- Do not use if you are pregnant or think you might be pregnant.
- Do not use if you are breastfeeding.
- Do not use if you are receiving a yellow fever vaccine or other live vaccines.
- Tell your doctor if you have liver, kidney, heart, or lung problems, or if you have a history of seizures.
Show 4 more warnings
- This medicine may increase the risk of developing another type of cancer later. Your doctor will discuss this with you.
- Both men and women must use effective birth control during treatment and for a period after treatment (6 months for women, 3 months for men).
- Male patients should discuss sperm banking with their doctor before starting treatment, as this medicine may affect fertility.
- This medicine can cause dizziness, headache, and blurred vision, which may affect your ability to drive or use machines. Do not drive or operate machinery if you experience these symptoms.