Thiotepa Abcur
Thiotepa Abcur is used to prepare patients for bone marrow transplantation by destroying bone marrow cells, allowing new, healthy blood cells to form.
Form
kuiva-aine välikonsentraatiksi infuusionestettä varten, liuos
Strength
100 mg
Active Ingredient
Thiotepa
Manufacturer
Abcur AB
How to Use
Dosage
Your doctor will calculate your dose based on your body surface area or weight and your medical condition.
Method
Thiotepa Abcur is given as an intravenous infusion (a drip into a vein) by a healthcare professional after the medicine is diluted. Each infusion takes 2-4 hours.
Important
Your doctor will determine your maximum daily dose, which depends on your condition and body size, ensuring a specific total amount is not exceeded during treatment.
Possible Side Effects
COMMON
- •Increased risk of infection
- •Blood poisoning (sepsis)
- •Low levels of white blood cells, platelets, and red blood cells (anemia)
- •Transplanted cells attacking your body (graft-versus-host disease)
- •Dizziness, headache, blurred vision
- •Uncontrolled shaking (seizures)
- •Tingling, prickling, or numbness
- •Partial loss of ability to move
- •Cardiac arrest
- •Nausea, vomiting, diarrhea
- •Inflammation in the mouth lining (mucositis)
- •Irritated stomach, esophagus, intestine
- •Colon inflammation
- •Loss of appetite
- •High blood sugar
- •Rash, itching, peeling skin
- •Changes in skin color (not jaundice)
- •Skin redness (erythema)
- •Hair loss
- •Back and abdominal pain
- •Muscle and joint pain
- •Abnormal heart rhythm
- •Lung inflammation
- •Enlarged liver
- •Changes in organ function
- •Liver vein blockage
- •Yellowing of skin and eyes (jaundice)
- •Hearing loss
- •Blocked lymphatic vessels
- •High blood pressure
- •High levels of liver, kidney, and digestive enzymes
- •Abnormal blood electrolyte levels
- •Weight gain
- •Fever, general weakness, chills
- •Bleeding
- •Nosebleeds
- •Swelling due to fluid retention (edema)
- •Pain or inflammation at the injection site
- •Eye infection (conjunctivitis)
- •Decreased sperm count
- •Vaginal bleeding
- •Missed periods (amenorrhea)
- •Memory loss
- •Delayed weight and height growth
- •Bladder problems
- •Low testosterone production
- •Low thyroid hormone production
- •Low pituitary gland activity
- •Confusion
- •Anxiety, confusion
- •Abnormal bulging of a brain artery (aneurysm)
- •High creatinine levels
- •Allergic reactions
- •Blood clot
- •Heart rhythm disorders
- •Heart failure
- •Cardiovascular system failure
- •Lack of oxygen
- •Fluid in the lungs (pulmonary edema)
- •Lung bleeding
- •Breathing stops
- •Blood in urine (hematuria) and moderate kidney problems
- •Bladder inflammation
- •Painful or difficult urination, less urine
- •Increased nitrogen compounds in the blood
- •Cataracts
- •Liver dysfunction
- •Brain bleeding
- •Cough
- •Constipation and stomach discomfort
- •Bowel obstruction
- •Stomach perforation
- •Changes in muscle tension
- •Poor muscle coordination
- •Bruises due to low platelet count
- •Menopausal symptoms
- •Cancer (secondary tumors)
- •Abnormal brain function
- •Male and female infertility
RARE
- •Skin inflammation and peeling (erythrodermic psoriasis)
- •Delirium, nervousness, hallucinations, agitation
- •Stomach or intestinal ulcer
- •Heart muscle inflammation (myocarditis)
- •Heart disease (cardiomyopathy)
Important Warnings
- Do not take if you are allergic to thiotepa or any other ingredients in this medicine.
- Do not take if you are pregnant or think you might be pregnant.
- Do not breastfeed while taking this medicine.
- Do not get live vaccines, such as yellow fever, bacterial, or live viral vaccines.
- Tell your doctor if you have liver, kidney, heart, or lung problems.
Show 6 more warnings
- Tell your doctor if you have had seizures or epilepsy.
- You will need regular blood tests during treatment because this medicine destroys bone marrow cells.
- This medicine may increase your risk of developing another type of cancer in the future.
- Both men and women must use effective contraception during and for a year after treatment. Men should not father children during this time.
- This medicine can affect fertility in both men and women. Men should consider sperm banking before treatment.
- Do not drive or use machines if you experience side effects like dizziness, headache, or blurred vision.