Thiotepa Abcur
Thiotepa Abcur is a medicine that helps prepare your body for a bone marrow transplant by destroying old bone marrow cells so new, healthy ones can grow.
Form
kuiva-aine välikonsentraatiksi infuusionestettä varten, liuos
Strength
15 mg
Active Ingredient
Thiotepa
Manufacturer
Abcur AB
How to Use
Dosage
Your doctor will decide your exact dose based on your body size and illness.
Method
This medicine is given as a drip into a vein (intravenous infusion) after it has been diluted, and each infusion takes 2-4 hours.
Important
Your doctor will determine your maximum daily dose, and the total dose over your treatment period will not exceed safe limits.
Possible Side Effects
COMMON
- •Increased risk of infections
- •Severe body infection (sepsis)
- •Low blood cell counts (white, red, platelets), causing anemia
- •Transplanted cells attacking your body
- •Dizziness, headache, blurred vision
- •Uncontrolled body shaking (seizures)
- •Tingling, prickling, or numbness
- •Partial loss of movement
- •Cardiac arrest
- •Nausea, vomiting, diarrhea
- •Mouth sores (mucositis)
- •Irritated stomach, esophagus, or bowels
- •Colon inflammation
- •Loss of appetite
- •High blood sugar
- •Rash, itching, peeling skin
- •Changes in skin color
- •Redness of skin
- •Hair loss
- •Back and belly pain
- •Muscle and joint pain
- •Abnormal heart rhythm
- •Lung inflammation
- •Enlarged liver
- •Changes in organ function
- •Blocked liver vein
- •Yellow skin and eyes (jaundice)
- •Hearing loss
- •Blocked lymph vessels
- •High blood pressure
- •High liver, kidney, and digestion enzyme levels
- •Abnormal blood electrolyte levels
- •Weight gain
- •Fever, general weakness, chills
- •Bleeding
- •Nosebleeds
- •General swelling due to fluid retention
- •Pain or inflammation at injection site
- •Eye infection (conjunctivitis)
- •Decreased sperm count
- •Vaginal bleeding
- •Missed periods (amenorrhea)
- •Memory loss
- •Delayed weight and height development
- •Bladder problems
- •Low testosterone production
- •Low thyroid hormone production
- •Pituitary gland problems
- •Anxiety, confusion
- •Abnormal bulging of a brain artery
- •High creatinine levels
- •Allergic reactions
- •Blood clot
- •Heart rhythm problems
- •Heart failure
- •Cardiovascular system failure
- •Lack of oxygen
- •Fluid in lungs (pulmonary edema)
- •Lung bleeding
- •Breathing stopping
- •Blood in urine and moderate kidney problems
- •Bladder inflammation
- •Painful or difficult urination, less urine
- •Increased nitrogen compounds in blood
- •Cataract
- •Liver failure
- •Brain bleeding
- •Cough
- •Constipation and stomach upset
- •Blocked bowels
- •Stomach perforation
- •Changes in muscle tension
- •Poor muscle coordination
- •Bruises from low platelets
- •Menopause symptoms
- •Secondary cancers
- •Abnormal brain function
- •Male and female infertility
RARE
- •Skin inflammation and peeling (red skin rash)
- •Delirium, nervousness, hallucinations, restlessness
- •Stomach or bowel ulcers
- •Heart muscle inflammation
- •Heart muscle disease
Important Warnings
- Do not take this medicine if you are allergic to thiotepa or any other ingredients in it.
- Do not take this medicine if you are pregnant or think you might be pregnant.
- Do not breastfeed while taking this medicine.
- Do not get live vaccines (like yellow fever, bacterial, or viral vaccines) while taking this medicine.
- Tell your doctor if you have liver, kidney, heart, or lung problems.
Show 4 more warnings
- Tell your doctor if you have or have had seizures (epilepsy).
- This medicine may increase your risk of getting another type of cancer in the future; your doctor will discuss this with you.
- This medicine can affect fertility in both men and women. Men should consider sperm banking before treatment and avoid fathering children during treatment and for one year afterward. Women should use effective birth control during treatment and for one year afterward.
- Some side effects, like dizziness, headache, or blurred vision, might affect your ability to drive or use machines. Do not drive or use machines if you have these symptoms.