Targiniq
Targiniq is a medicine for severe pain that also helps prevent constipation, a common side effect of strong pain relievers.
How to Use
Dosage
The usual starting dose for adults is one 10 mg oxycodone / 5 mg naloxone tablet taken every 12 hours. Your doctor will adjust the dose based on your pain.
Method
Swallow the tablets whole with about half a glass of water, with or without food. Do not break, chew, or crush them. Take them at the same times every 12 hours (e.g., 8 AM and 8 PM).
The maximum daily dose is 160 mg of oxycodone hydrochloride and 80 mg of naloxone hydrochloride. Do not exceed a total of 400 mg of oxycodone hydrochloride per day.
Possible Side Effects
- •Abdominal pain
- •Constipation
- •Diarrhea
- •Dry mouth
- •Nausea
- •Vomiting
- •Decreased appetite
- •Dizziness
- •Headache
- •Sweating
- •Itching
- •Drowsiness
- •Fatigue
- •Feeling of weakness
- •Flatulence
- •Hot flashes
- •Skin reactions or rash
- •Vertigo (spinning sensation)
- •Sleep problems
- •Indigestion
- •Abdominal distension
- •Anxiety
- •Confusion
- •Depression
- •Nervousness
- •Chest tightness
- •Palpitations (fast or irregular heartbeat)
- •Gallstone attack
- •Chest pain
- •General malaise (feeling unwell)
- •Pain
- •Swelling of hands, ankles or feet
- •Difficulty concentrating
- •Speech disorders
- •Tremor (shaking)
- •Breathing difficulties
- •Restlessness
- •Chills
- •Increased liver enzyme levels
- •Increased blood pressure
- •Decreased libido
- •Runny nose
- •Cough
- •Allergic reactions
- •Weight loss
- •Accidental injuries
- •Frequent urination
- •Muscle cramps
- •Muscle twitching
- •Muscle pain
- •Impaired vision
- •Epileptic seizures (especially in people prone to seizures)
- •Decreased blood pressure
- •Withdrawal symptoms (e.g., agitation)
- •Fainting
- •Weakness
- •Thirst
- •Altered taste
- •Increased heart rate
- •Drug dependence
- •Tooth changes
- •Yawning
- •Weight gain
- •Euphoria (very strong feeling of happiness)
- •Severe drowsiness
- •Erectile dysfunction
- •Nightmares
- •Hallucinations
- •Shallow breathing
- •Urination difficulties
- •Aggressiveness
- •Skin tingling/prickling sensation
- •Burping
- •Sleep apnea (breathing stops during sleep)
- •Thinking disturbances
Important Warnings
- Do not take if you are allergic to any ingredients in Targiniq.
- Do not break, chew, or crush the tablets; this can release too much medicine at once and be dangerous.
- Avoid alcohol and grapefruit juice while taking this medicine, as they can increase side effects or cause serious breathing problems.
- This medicine can cause slow and shallow breathing, especially with too high a dose, which can be life-threatening. Seek immediate medical help if this happens.
- This medicine contains an opioid and can lead to dependence or addiction, even with regular use.
Show 2 more warnings
- Tell your doctor if you have severe lung disease (like COPD or severe asthma), severe liver problems, or a condition called cor pulmonale.
- Do not use if you have a bowel obstruction (paralytic ileus) not caused by other opioid treatment.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. Reduce the dose already in mild renal impairment. Increases the risk of confusion and falling. Need for laxative is often necessary. Consider potential interactions. Avoid grapefruit. (updated 24.3.2025)