Targiniq
Targiniq is a strong pain reliever that works for 12 hours and contains naloxone to help prevent constipation.
How to Use
Dosage
The usual starting dose is one 10 mg/5 mg tablet every 12 hours.
Method
Swallow the whole tablet with enough water. Do not break, chew, or crush it. You can take it with or without food.
The maximum daily dose is 160 mg of oxycodone hydrochloride and 80 mg of naloxone hydrochloride. Your doctor might give you more oxycodone without naloxone, but the total oxycodone should not exceed 400 mg per day.
Possible Side Effects
- •Stomach pain
- •Constipation
- •Diarrhea
- •Dry mouth
- •Feeling sick (nausea)
- •Being sick (vomiting)
- •Gas (bloating)
- •Loss of appetite
- •Dizziness (feeling lightheaded)
- •Headache
- •Hot flashes
- •Feeling unusually weak or tired
- •Itching
- •Skin rash
- •Sweating a lot
- •Spinning sensation (vertigo)
- •Trouble sleeping
- •Feeling sleepy
- •Stomach swelling
- •Unusual thoughts or confusion
- •Feeling anxious or nervous
- •Feeling depressed
- •Tightness or pain in the chest
- •Fast heart rate or heart palpitations
- •Gallbladder problems (like gallstones)
- •Feeling generally unwell or weak
- •Swelling in your hands, ankles, or feet
- •Trouble concentrating or speaking
- •Shaking (tremor)
- •Difficulty breathing
- •Feeling restless or having chills
- •Changes in liver test results
- •High blood pressure
- •Lower sex drive
- •Problems with teeth
- •Getting addicted to the medicine
- •Runny nose or cough
- •Allergic reactions
- •Weight changes (loss or gain)
- •Injuries from falls
- •Needing to pee more often
- •Muscle cramps, twitches, or pain
- •Blurry vision
- •Seizures (fits)
- •Feeling very happy (euphoria)
- •Seeing or hearing things that aren't real (hallucinations)
- •Very severe drowsiness
- •Shallow breathing
- •Erection problems
- •Trouble urinating
- •Nightmares
- •Feeling aggressive
- •Yawning a lot
- •Tingling or numb skin sensation
- •Burping
- •Pauses in breathing while you sleep (sleep apnea)
Important Warnings
- Do not take if you are allergic to oxycodone, naloxone, or any other ingredients in this medicine.
- Do not take if you have severe breathing problems or a serious lung disease.
- Do not take if you have moderate to severe liver problems. Discuss with your doctor if you have kidney or mild liver problems.
- This medicine can cause sleep-related breathing problems like sleep apnea (pauses in breathing while you sleep). If you notice symptoms like pauses in breathing during sleep, waking up due to shortness of breath, or feeling very sleepy during the day, tell your doctor.
- Swallow tablets whole. Do not break, chew, or crush them, as this can lead to a dangerous overdose.
Show 2 more warnings
- This medicine contains oxycodone, which is an opioid. It can lead to dependence and addiction, especially with long-term use or high doses.
- Do not drink alcohol or grapefruit juice while taking this medicine, as it can increase side effects like drowsiness and breathing problems.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. Reduce the dose already in mild renal impairment. Increases the risk of confusion and falling. Need for laxative is often necessary. Consider potential interactions. Avoid grapefruit. (updated 24.3.2025)