Targiniq
Targiniq is an extended-release medicine used to treat severe pain or severe restless legs syndrome, and it helps prevent constipation often caused by similar pain medicines.
How to Use
Dosage
For pain, the usual starting dose is one 10 mg/5 mg extended-release tablet every 12 hours. For restless legs syndrome, the usual starting dose is one 5 mg/2.5 mg extended-release tablet every 12 hours.
Method
Swallow the extended-release tablet whole with enough liquid; do not break, chew, or crush it, and take the tablets every 12 hours at the same times each day.
Your doctor will decide your maximum daily dose. For pain, the maximum daily dose is 160 mg oxycodone hydrochloride and 80 mg naloxone hydrochloride. For restless legs syndrome, the maximum daily dose is 60 mg oxycodone hydrochloride and 30 mg naloxone hydrochloride.
Possible Side Effects
- •Abdominal pain
- •Nausea
- •Constipation
- •Flatulence
- •Diarrhea
- •Decreased appetite
- •Dry mouth
- •Skin rash or reactions
- •Indigestion
- •Dizziness
- •Sweating
- •Vomiting
- •Headache
- •Vertigo (spinning sensation)
- •Hot flashes
- •Insomnia (trouble sleeping)
- •Drowsiness (feeling sleepy)
- •Unusual weakness
- •Fatigue or exhaustion
- •Itching
- •Abdominal swelling
- •Palpitations (fast or strong heartbeat)
- •Runny nose
- •Thinking problems
- •Gallstone attack
- •Cough
- •Anxiety
- •Chest pain
- •Allergic reactions
- •Confusion
- •General malaise (feeling unwell)
- •Weight loss
- •Depression
- •Nervousness
- •Swelling in hands, ankles, or feet
- •Increased urination frequency
- •Chest tightness
- •Muscle cramps
- •Muscle twitching
- •Muscle pain
- •Low or high blood pressure
- •Blurred vision
- •Withdrawal symptoms (e.g., agitation)
- •Epileptic seizures
- •Fainting
- •Severe weakness
- •Thirst
- •Altered taste
- •Chills
- •Increased liver enzymes
- •Decreased sex drive
- •Increased heart rate
- •Drug dependence
- •Dental changes
- •Weight gain
- •Yawning
- •Sleep apnea (breathing stops during sleep)
- •Hallucinations
- •Aggressiveness
- •Erectile dysfunction
- •Sudden sleep onset
- •Speech problems
Important Warnings
- Do not take if you are allergic to oxycodone, naloxone, or any other ingredient in this medicine.
- Do not take if you have serious breathing problems, such as very slow or shallow breathing, severe lung disease, or severe asthma.
- Do not take if you have moderate to severe liver failure.
- Do not take if you have a bowel blockage that is not caused by opioid medicines.
- This medicine contains an opioid and can cause dependence and addiction. There is a risk of misuse.
Show 4 more warnings
- Tell your doctor if you are taking other medicines that make you sleepy, like sedatives or antidepressants, as this can increase side effects.
- Do not drink alcohol or grapefruit juice while taking this medicine.
- If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
- This medicine can make you drowsy. Do not drive or operate machinery if you feel sleepy.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. Reduce the dose already in mild renal impairment. Increases the risk of confusion and falling. Need for laxative is often necessary. Consider potential interactions. Avoid grapefruit. (updated 24.3.2025)