Targiniq
This medicine is used to treat severe pain when other pain relievers don't work, and to treat severe restless legs syndrome when other medicines can't be used, while also helping prevent constipation.
How to Use
Dosage
The typical starting dose for adults is one extended-release tablet (e.g., 10 mg/5 mg for pain or 5 mg/2.5 mg for restless legs) taken every 12 hours; your doctor will tell you the exact dose.
Method
Swallow the tablets whole with about half a glass of water. Do not break, chew, or crush them. You can take them with or without food, every 12 hours at the same times each day (e.g., 8 AM and 8 PM).
For pain, the maximum daily dose is 160 mg of oxycodone hydrochloride and 80 mg of naloxone hydrochloride. For restless legs syndrome, the maximum is 60 mg of oxycodone hydrochloride and 30 mg of naloxone hydrochloride. Your doctor will set your exact maximum dose.
Possible Side Effects
- •Abdominal pain
- •Nausea
- •Unusual weakness or tiredness
- •Constipation
- •Flatulence (gas)
- •Diarrhea
- •Decreased or lost appetite
- •Itching
- •Dry mouth
- •Skin reactions or rash
- •Digestive problems
- •Dizziness or vertigo
- •Sweating
- •Vomiting
- •Headache
- •Hot flashes
- •Sleep difficulties
- •Drowsiness
- •Depression
- •Tingling in hands or feet
- •Impaired vision
- •Tremor
- •Decreased blood pressure
- •Increased blood pressure
- •Increased liver enzyme values
- •Chest pain
- •Chills
- •Pain
- •Abdominal swelling
- •Palpitations (fast or strong heartbeat)
- •Runny nose
- •Thought disturbances
- •Gallstone attack
- •Cough
- •Anxiety
- •Allergic or hypersensitivity reactions
- •Confusion
- •General malaise (feeling unwell)
- •Weight loss
- •Nervousness
- •Swelling of hands, ankles or feet
- •Frequent urination
- •Pressure in chest
- •Muscle cramps
- •Concentration difficulties
- •Muscle twitching
- •Speech disorder
- •Epileptic seizures
- •Agitation
- •Restlessness
- •Fainting
- •Weakness
- •Thirst
- •Taste disturbance
- •Decreased libido (sex drive)
- •Increased heart rate
- •Drug dependence
- •Tooth changes
- •Weight gain
- •Yawning
- •Feeling of extreme happiness (euforia)
- •Hallucinations
- •Tingling skin sensation
- •Severe drowsiness
- •Burping
- •Erectile dysfunction
- •Sleep apnea (breathing stops during sleep)
- •Nightmares
- •Urination difficulties
- •Aggressiveness
- •Sudden onset of sleep
- •Shallow breathing
- •Accidental injuries
- •Gallflow problems (dysfunction of sphincter of Oddi)
- •Withdrawal symptoms in newborns
Important Warnings
- Do not take this medicine if you are allergic to oxycodone, naloxone, or any other ingredient.
- Do not take if you have severe breathing problems (like slow, shallow breathing) or severe lung disease (like severe asthma or COPD).
- Tell your doctor if you have liver or kidney problems, or if you have a blocked intestine (paralytic ileus).
- Avoid alcohol and grapefruit juice while taking this medicine, as they can increase side effects.
- This medicine contains an opioid (oxycodone) and can cause dependence or addiction. Follow your doctor's instructions carefully.
Show 3 more warnings
- Do not break, chew, or crush the tablets. Swallow them whole, as breaking them can release a dangerous amount of medicine at once.
- This medicine can make you sleepy or cause you to fall asleep suddenly. Do not drive or operate machinery if you experience these effects.
- Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. Reduce the dose already in mild renal impairment. Increases the risk of confusion and falling. Need for laxative is often necessary. Consider potential interactions. Avoid grapefruit. (updated 24.3.2025)