Targiniq
Targiniq is a prolonged-release tablet used to treat severe pain or severe restless legs syndrome in adults, and it also contains an ingredient to prevent constipation.
How to Use
Dosage
Your doctor will decide your correct dose. Typically, you take one 10 mg/5 mg prolonged-release tablet every 12 hours.
Method
Swallow the tablet whole. Do not break, chew, or crush it. Take it with half a glass of water, with or without food, every 12 hours at the same time each day.
Your doctor will determine your maximum daily dose. For pain, it is typically up to 160 mg/80 mg of Targiniq, and for restless legs, it is typically up to 60 mg/30 mg.
Possible Side Effects
- •Stomach pain
- •Nausea
- •Constipation
- •Gas
- •Diarrhea
- •Reduced or lost appetite
- •Dry mouth
- •Skin reactions or rash
- •Dizziness
- •Sweating
- •Vomiting
- •Headache
- •Sleep problems
- •Drowsiness
- •Tiredness or fatigue
- •Itching
- •Bloating
- •Heart palpitations
- •Anxiety
- •Depression
- •Muscle pain
- •Swelling of hands, ankles, or feet
- •Difficulty breathing
- •Fast heart rate
- •Hallucinations
- •Sleep apnea (breathing stops during sleep)
- •Drug dependence
- •Sudden sleepiness
- •Urination problems
Important Warnings
- Do not take if you are allergic to oxycodone, naloxone, or any other ingredients in this medicine.
- Do not take if you have severe breathing problems (like very slow or shallow breathing, severe lung disease, or severe asthma).
- Do not take if you have moderate to severe liver problems.
- Do not take if you have a bowel blockage not caused by opioids.
- This medicine contains an opioid and can cause addiction. Do not take more than your doctor prescribes.
Show 4 more warnings
- Swallow tablets whole. Do not crush, chew, or break them, as this can be dangerous.
- Avoid alcohol and grapefruit juice while taking this medicine, as they can increase side effects.
- If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
- This medicine can make you sleepy and affect your ability to drive or use machines.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. Reduce the dose already in mild renal impairment. Increases the risk of confusion and falling. Need for laxative is often necessary. Consider potential interactions. Avoid grapefruit. (updated 24.3.2025)