Tadex
Tadex tablets are used to treat breast cancer by blocking the effects of estrogen.
Form
tabletti
Strength
20 mg
Active Ingredient
Tamoxifen citrate
Manufacturer
Orion Corporation
How to Use
Dosage
The usual dose is 20-40 mg per day.
Method
Take the tablets by mouth with enough liquid, like a glass of water. A 40 mg daily dose can be taken once a day or divided into two doses.
Important
Do not exceed 40 mg per day.
Possible Side Effects
COMMON
- •Fluid retention (swelling)
- •Feeling sick (nausea)
- •Skin rash
- •Hot flashes
- •Less frequent periods before menopause
- •Vaginal discharge
- •Vaginal bleeding
RARE
- •Anemia (low red blood cells)
- •Low white blood cells
- •High levels of fats in the blood (triglycerides)
- •Weakness
- •Headache
- •Vision problems, such as cataracts or changes to the retina/cornea
- •Increased risk of blood clots and vein inflammation
- •Complications from blood clots, such as lung blood clots or deep vein clots
- •Stroke or issues with blood flow to the brain
- •Leg cramps
- •Vomiting
- •Stomach pain
- •Constipation
- •Diarrhea
- •Loss of appetite
- •Changes in liver enzyme values or fatty liver
- •Dry skin
- •Hair loss
- •Allergic reactions
- •Bone pain (at the start of treatment)
- •Itching in the genital area
- •Irregular periods or absent periods
- •Changes in the womb lining (e.g., overgrowth, tumors, polyps, fibroids, or endometriosis)
- •Cancer of the womb lining
- •Low platelet count (cells that help blood clot)
- •High calcium in the blood (usually at the start of treatment for those with bone metastases)
- •Pancreatitis (inflammation of the pancreas)
- •Dizziness
- •Liver cirrhosis (chronic liver disease)
- •Sweating
- •Muscle pain
- •Weight gain
- •Womb tumors (sarcoma) or ovarian cysts (in patients treated before menopause)
- •Tumor activation or pain at the tumor site
- •Low white blood cells (agranulocytosis or neutropenia)
- •Depression, confusion, or trouble sleeping
- •Optic nerve disease, worsening vision, or changes to the retina/optic nerve/cornea
- •Lung inflammation (interstitial pneumonia) or cough
- •Jaundice, liver failure, liver cell damage, or liver necrosis
- •Severe skin reactions (e.g., erythema multiforme, pemphigoides bullosus) or skin vasculitis (inflammation of skin blood vessels)
- •Thinning hair or swelling of the skin and mucous membranes (angioedema)
- •General feeling of being unwell
- •Increased need to urinate
- •Stiff leg muscles
- •Very low white blood cells (severe neutropenia) or low counts of all blood cells (pancytopenia)
- •Very high fat levels in the blood (severe hypertriglyceridemia)
- •Lupus (skin rash)
- •Porphyria (skin condition)
- •Skin rash after radiation therapy that looks like a severe sunburn
- •Worsening of symptoms of hereditary angioedema
Important Warnings
- Do not take Tadex if you are allergic to tamoxifen or any other ingredient in this medicine.
- Do not use Tadex if you are pregnant or breastfeeding. Avoid getting pregnant during treatment and for 9 months after stopping treatment.
- Do not use Tadex if you are also taking anastrozole.
- If you or a family member have had a blood clot, or if you get symptoms of a blood clot (e.g., swelling in your leg, chest pain, or shortness of breath), stop Tadex and contact a doctor immediately.
- If you get symptoms of a stroke (e.g., sudden weakness or paralysis in arms/legs, speech/walking difficulties, trouble holding objects or thinking), contact a doctor immediately.
Show 3 more warnings
- If you have a history of hereditary angioedema, or if you get symptoms like swelling of your face, lips, tongue, or throat, with difficulty swallowing or breathing, contact a doctor immediately.
- If you develop severe skin reactions (e.g., red spots, blisters, peeling skin, or fever), stop Tadex and contact a doctor immediately.
- Tadex can make your vision worse or make you feel weak. Be extra careful when driving or using machines.