Sunitinib Viatris
Sunitinib Viatris is a cancer medicine that works by stopping certain cancer cells from growing and spreading.
Form
kapseli, kova
Strength
37.5 mg
Active Ingredient
Sunitinib
Manufacturer
Viatris Limited
How to Use
Dosage
For GIST and kidney cancer: 50 mg once daily for 28 days, followed by a 14-day break. For pancreatic NET: 37.5 mg once daily without a break.
Method
Take the capsules whole with water, with or without food, exactly as your doctor or pharmacist tells you.
Important
The maximum daily dose is 50 mg (for GIST/kidney cancer) or 37.5 mg (for pancreatic NET), as prescribed by your doctor.
Possible Side Effects
COMMON
- •Decreased number of platelets, red blood cells, and/or white blood cells.
- •Shortness of breath, cough.
- •High blood pressure.
- •Severe tiredness, weakness, difficulty falling asleep.
- •Swelling (fluid retention under the skin, around eyes, in the lungs).
- •Mouth and gum problems (pain, sores, inflammation), altered taste, nausea, vomiting, diarrhea, constipation, stomach pain, loss of appetite, difficulty swallowing, gas, hemorrhoids.
- •Underactive thyroid.
- •Dizziness, headache.
- •Nosebleeds.
- •Back, joint, and limb pain, muscle pain and cramps.
- •Skin and hair color changes, rash (on palms/soles), dry skin, itching, flaking, blisters, nail problems, acne-like reactions, hair loss.
- •Fever, chills.
- •Blood clots in vessels, reduced blood flow to heart muscle, chest pain, decreased blood pumped by the heart.
- •Infections, severe infections (sepsis).
- •Low blood sugar.
- •Protein in urine (may cause swelling).
- •Flu-like symptoms.
- •Abnormal lab results (blood, pancreatic, and liver enzymes), high uric acid in blood.
- •Weight loss.
- •Numbness or altered sensation (touch sensitivity, in arms and legs).
- •Heartburn, dehydration, hot flashes.
- •Abnormally colored urine.
- •Depression.
- •Dry nose, blocked nose, watery eyes.
RARE
- •Life-threatening soft tissue infection (in anal and genital areas).
- •Stroke.
- •Heart attack or abnormal heart rhythm.
- •Fluid around the heart.
- •Liver failure, liver inflammation (hepatitis).
- •Pancreas inflammation and resulting stomach pain.
- •Bowel perforation due to tumor breakdown, tumor lysis syndrome (TLS).
- •Gallbladder inflammation (swelling, redness, gallstones).
- •Abnormal connection within the body or to the skin (fistula).
- •Jaw bone damage (pain in mouth, swelling, numbness, loose teeth).
- •Overactive thyroid, thyroid inflammation.
- •Wound healing problems after surgery.
- •Increased muscle enzyme levels in blood.
- •Severe allergic reaction (rash, swelling, breathing difficulties).
- •Large intestine inflammation (colitis).
- •Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), painful skin sores (pyoderma gangrenosum).
- •Muscle breakdown that can harm kidneys (rhabdomyolysis).
- •Abnormal brain changes (headache, confusion, seizures, vision loss).
- •Small blood vessel damage (thrombotic microangiopathy, TMA).
Important Warnings
- Do not use this medicine if you are allergic to sunitinib or any other ingredient in this medicine.
- This medicine can raise your blood pressure; your doctor will check it regularly.
- Tell your doctor if you have had bleeding, bruising, or blood count problems.
- Inform your doctor if you have heart problems, such as severe tiredness, shortness of breath, or swelling.
- Seek immediate medical attention if you have symptoms of a blood clot, such as chest pain, shortness of breath, or weakness on one side of your body.
Show 8 more warnings
- Inform your doctor if you have or have had blood vessel bulges (aneurysms) or damage to small blood vessels (TMA).
- Tell your doctor if you have thyroid, pancreas, gallbladder, liver, or kidney problems.
- Inform your doctor or dentist if you are having surgery or dental work, as the medicine can affect healing.
- Contact your doctor immediately if you develop a severe rash, painful skin sores, or signs of a skin infection.
- Tell your doctor if you have had seizures or diabetes, as blood sugar levels may need monitoring.
- Use effective birth control during treatment. Do not breastfeed while taking this medicine.
- Be careful when driving or operating machinery if you feel dizzy or tired.
- Avoid grapefruit juice during treatment.