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Sunitinib Sandoz

Sunitinib Sandoz is a cancer medicine that works by stopping certain proteins from helping cancer cells grow and spread.

Form
kapseli, kova
Strength
25 mg
Active Ingredient
Sunitinib
Manufacturer
Sandoz A/S

How to Use

Dosage

For GIST or kidney cancer, take 50 mg once a day for 28 days, then stop for 14 days. This is a 6-week cycle. For pancreatic NET, take 37.5 mg once a day without a break.

Method

You can take this medicine with or without food.

Important

The maximum daily dose is 50 mg for GIST or kidney cancer, or 37.5 mg for pancreatic NET.

Possible Side Effects

COMMON
  • •Low levels of blood cells (platelets, red blood cells, white blood cells).
  • •Shortness of breath.
  • •High blood pressure.
  • •Feeling very tired or weak.
  • •Swelling due to fluid under the skin or around the eyes.
  • •Mouth pain or soreness, mouth sores or inflammation, dry mouth, taste changes, stomach upset, nausea, vomiting, diarrhea, constipation, stomach pain or swelling, loss of appetite.
  • •Underactive thyroid gland.
  • •Dizziness.
  • •Headache.
  • •Nosebleeds.
  • •Back pain, joint pain.
  • •Pain in arms and legs.
  • •Yellow or discolored skin, darker skin patches, hair color changes, rash on hands and feet, skin rash, dry skin.
  • •Cough.
  • •Fever.
  • •Trouble sleeping.
  • •Blood clots in blood vessels.
  • •Reduced blood flow to the heart muscle due to blocked or narrowed heart arteries.
  • •Chest pain.
  • •Reduced amount of blood pumped by the heart.
  • •Fluid buildup in the body, including around the lungs.
  • •Infections.
  • •Serious infection complications, such as blood infection leading to tissue damage, organ failure, and death.
  • •Low blood sugar.
  • •Protein in urine, sometimes causing swelling.
  • •Flu-like symptoms.
  • •Abnormal blood test results, including high pancreas and liver enzymes, and high uric acid.
  • •Hemorrhoids, rectal pain, bleeding gums, difficulty swallowing, burning or painful tongue, inflammation of digestive tract lining, gas, weight loss.
  • •Muscle and bone pain, muscle weakness, muscle fatigue, muscle aches, muscle cramps.
  • •Dry nose, stuffy nose.
  • •Increased tearing.
  • •Unusual skin sensations, itching, peeling or inflamed skin, blisters, acne, nail discoloration, hair loss.
  • •Unusual sensations in limbs.
  • •Unusual reduced or increased sensitivity, especially to touch.
  • •Heartburn.
  • •Dehydration.
  • •Hot flashes.
  • •Abnormal colored urine.
  • •Depression.
  • •Chills.
RARE
  • •Life-threatening infection in soft tissues, including around the anus and genitals.
  • •Stroke.
  • •Heart attack due to blocked or reduced blood flow to the heart.
  • •Changes in the heart's electrical activity or abnormal heart rhythm.
  • •Fluid buildup around the heart (pericardial effusion).
  • •Liver failure.
  • •Stomach pain caused by inflammation of the pancreas.
  • •Bowel perforation due to tumor breakdown.
  • •Gallbladder inflammation (swelling and redness), possibly with gallstones.
  • •Abnormal connection (fistula) from a body cavity to another or to the skin.
  • •Mouth, teeth, or jaw pain, swelling or sores in the mouth, numbness or heavy feeling in the jaw, or loose teeth. These can be signs of jaw bone damage (osteonecrosis).
  • •Overactive thyroid gland.
  • •Problems with wound healing after surgery.
  • •Increased levels of muscle enzymes in the blood.
  • •Severe allergic reaction with symptoms like hay fever, rash, itching, hives, body swelling, and breathing difficulties.
  • •Colon inflammation (colitis, ischemic colitis).
  • •Severe skin or mucous membrane reactions (like Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme).
  • •Tumor lysis syndrome (TLS), which causes metabolic problems due to breaking down cancer cells. Symptoms include nausea, shortness of breath, irregular heartbeat, muscle cramps, seizures, cloudy urine, tiredness, and abnormal lab tests. This can lead to kidney problems.
  • •Unusual muscle cell damage (rhabdomyolysis) that can lead to kidney problems.
  • •Abnormal brain changes (Posterior Reversible Encephalopathy Syndrome - PRES) causing symptoms like headache, confusion, seizures, and vision loss.
  • •Painful skin ulcers (pyoderma gangrenosum).
  • •Liver inflammation (hepatitis).
  • •Thyroid inflammation.
  • •Damage to small blood vessels (thrombotic microangiopathy, TMA).
  • •Enlargement and weakening of a blood vessel wall, or a tear in a blood vessel wall (aneurysms and arterial dissections).
  • •Lack of energy, confusion, sleepiness, unconsciousness/coma - these can be signs of brain damage due to high ammonia levels in the blood.

Important Warnings

  • Do not take Sunitinib Sandoz if you are allergic to sunitinib or any other ingredient in this medicine.
  • Sunitinib Sandoz can raise your blood pressure, and your doctor may need to check and treat it.
  • This medicine can increase the risk of bleeding or affect your blood cells. Tell your doctor if you bleed easily or bruise often.
  • Sunitinib Sandoz can cause heart problems. Tell your doctor if you feel very tired, short of breath, or have swollen feet or ankles.
  • This medicine can affect your heart rhythm. Tell your doctor if you feel dizzy, faint, or have an unusual heartbeat.
Show 15 more warnings
  • Seek immediate medical help if you get chest pain, shortness of breath, numbness on one side of your body, or speech problems, as these can be signs of blood clots.
  • Tell your doctor if you have had an aneurysm (a bulge in a blood vessel) or a tear in a blood vessel wall.
  • Tell your doctor if you have fever, tiredness, bruising, bleeding, swelling, confusion, vision loss, or seizures, as these can be signs of small blood vessel damage.
  • This medicine can affect your thyroid. Tell your doctor if you feel more tired, cold, or your voice gets deeper.
  • Tell your doctor if you have stomach pain, nausea, vomiting, or fever, as these could be signs of pancreas or gallbladder inflammation.
  • Tell your doctor if you have itching, yellow skin or eyes, dark urine, or pain in the upper right side of your stomach, as these can be signs of liver problems.
  • Your doctor will check your kidney function regularly.
  • This medicine can affect wound healing. Your doctor will decide when you can stop and restart treatment around surgery.
  • You might need a dental check-up before starting treatment. Tell your dentist if you have mouth pain, swelling, or loose teeth.
  • Tell your doctor right away if you develop painful skin sores, fast-spreading skin infections, or severe rashes with blisters, as these can be serious.
  • Tell your doctor immediately if you have high blood pressure, headache, or vision loss, as these can be signs of seizures.
  • If you have diabetes, your blood sugar needs to be checked regularly, and your medicine dose may need to be changed.
  • Avoid drinking grapefruit juice while taking this medicine.
  • Do not take this medicine if you are pregnant or breastfeeding. Use reliable birth control if you can get pregnant.
  • This medicine can make you feel dizzy or very tired. Be careful when driving or operating machines.

Additional Information

ATC Code: L01EX01
→ View Professional Information (PDF)→ View Patient Leaflet (PDF)