Sorafenib Viatris
Sorafenib Viatris is used to treat advanced kidney cancer, liver cancer, and a type of thyroid cancer by slowing cancer cell growth.
Form
tabletti, kalvopäällysteinen
Strength
200 mg
Active Ingredient
Sorafenib tosilate
Manufacturer
Viatris Limited
How to Use
Dosage
The recommended dose for adults is two 200 mg tablets, twice a day.
Method
Take the tablets with a glass of water, either without food or with a low-fat meal. Do not take with a high-fat meal as it can reduce the medicine's effect. If you plan to eat a high-fat meal, take the tablets at least 1 hour before or 2 hours after. Take it at roughly the same time each day.
Important
The maximum daily dose is 800 mg, which is 4 tablets.
Possible Side Effects
COMMON
- •Diarrhea
- •Nausea (feeling sick)
- •Feeling weak or tired (fatigue)
- •Pain (including mouth pain, stomach pain, headache, bone pain, tumor pain)
- •Hair loss (alopecia)
- •Red or painful hands or feet (hand-foot skin reaction)
- •Itching or rash
- •Vomiting
- •Bleeding (including in the brain, bowel wall, and airways)
- •High blood pressure (hypertension)
- •Infections
- •Loss of appetite (anorexia)
- •Constipation
- •Joint pain (arthralgia)
- •Fever
- •Weight loss
- •Dry skin
- •Flu-like symptoms
- •Indigestion (dyspepsia)
- •Difficulty swallowing (dysphagia)
- •Inflamed or dry mouth, tongue pain (stomatitis and mucous membrane inflammation)
- •Low blood calcium levels (hypocalcemia)
- •Low blood potassium levels (hypokalemia)
- •Low blood sugar levels (hypoglycemia)
- •Muscle pain (myalgia)
- •Numbness or tingling in fingers and toes (peripheral sensory neuropathy)
- •Depression
- •Erectile dysfunction (impotence)
- •Voice changes (dysphonia)
- •Acne
- •Inflamed, dry, or peeling skin (dermatitis, skin desquamation)
- •Heart failure
- •Heart attack or chest pain
- •Ringing in the ears (tinnitus)
- •Kidney failure
- •High levels of protein in urine (proteinuria)
- •General weakness or lack of strength (asthenia)
- •Decreased white blood cell count (leukopenia and neutropenia)
- •Decreased red blood cell count (anemia)
- •Low platelet count (thrombocytopenia)
- •Hair follicle inflammation (folliculitis)
- •Underactive thyroid (hypothyroidism)
- •Low sodium levels in blood (hyponatremia)
- •Taste disturbance (dysgeusia)
- •Redness of the face and often other body parts (flushing)
- •Runny nose (rhinorrhea)
- •Heartburn (gastroesophageal reflux disease)
- •Skin cancer (keratoacanthoma or squamous cell skin cancer)
- •Thickening of the outer skin layer (hyperkeratosis)
- •Sudden, involuntary muscle spasms
RARE
- •Inflamed stomach lining (gastritis)
- •Stomach pain due to inflammation of the pancreas, gallbladder, and/or bile ducts
- •Yellow skin or eyes (jaundice) due to high bile pigment levels (hyperbilirubinemia)
- •Allergic-like reactions (including skin reaction and hives)
- •Dehydration
- •Enlarged breasts (gynecomastia)
- •Breathing difficulties (lung disease)
- •Eczema
- •Overactive thyroid (hyperthyroidism)
- •Rash with blisters (erythema multiforme)
- •Abnormally high blood pressure
- •Hole in the bowel wall (gastrointestinal perforation)
- •Temporary swelling in the back of the brain causing headache, changes in consciousness, seizures, and vision problems (posterior reversible encephalopathy syndrome)
- •Sudden, severe allergic reaction (anaphylactic reaction)
- •Allergic reaction with skin swelling (e.g., face, tongue) that can cause difficulty breathing or swallowing (angioedema)
- •Abnormal heart rhythm (QT prolongation)
- •Liver inflammation causing nausea, vomiting, stomach pain, and jaundice (drug-induced hepatitis)
- •Sunburn-like rash on skin previously exposed to radiation, which can be severe ("radiation recall" dermatitis)
- •Severe skin and/or mucous membrane reactions causing painful blisters, fever, and skin peeling (Stevens-Johnson syndrome and toxic epidermal necrolysis)
- •Abnormal muscle breakdown leading to kidney problems (rhabdomyolysis)
- •Kidney damage causing large amounts of protein to leak into the urine (nephrotic syndrome)
- •Inflammation of blood vessels in the skin causing a rash (leukocytoclastic vasculitis)
- •Worsening brain function, possibly causing drowsiness, behavioral changes, or confusion (encephalopathy)
- •Enlargement and weakening of a blood vessel wall, or a tear in a blood vessel wall (aneurysms and arterial dissections)
- •Nausea, shortness of breath, irregular heartbeat, muscle cramps, seizures, cloudy urine, and tiredness (Tumour Lysis Syndrome - TLS)
Important Warnings
- Do not take Sorafenib Viatris if you are allergic to sorafenib or any other ingredient in this medicine.
- This medicine can cause skin rashes and changes, especially on your hands and feet. Your doctor may need to pause or stop treatment if these reactions are severe.
- This medicine can raise blood pressure. Your doctor will check your blood pressure regularly and may prescribe medicine for high blood pressure.
- Tell your doctor if you have or have had an aneurysm (a weakened, bulging blood vessel) or a torn blood vessel.
- This medicine can increase the risk of bleeding, especially if you take blood thinners like warfarin or fenprocoumon.
Show 6 more warnings
- If you experience chest pain or heart problems, your doctor might pause or stop your treatment.
- Inform your doctor if you have an abnormal heart rhythm (e.g., prolonged QT interval).
- This medicine can affect wound healing. Treatment is usually paused before surgery and your doctor will decide when to restart it.
- If you have severe liver problems, side effects may be stronger.
- Holes in the stomach or bowel wall (perforation) can occur. If this happens, your doctor will stop treatment.
- Seek immediate medical attention if you have nausea, shortness of breath, irregular heartbeat, muscle cramps, seizures, cloudy urine, and tiredness, as these could be signs of a serious, life-threatening condition (Tumour Lysis Syndrome).