Sorafenib Stada
Sorafenib STADA is a medication used to treat certain cancers by slowing cancer cell growth and limiting their blood supply.
Form
tabletti, kalvopäällysteinen
Strength
200 mg
Active Ingredient
Sorafenib tosilate
Manufacturer
STADA Arzneimittel AG
How to Use
Dosage
The recommended dose for adults is two 200 mg tablets twice a day.
Method
Swallow the tablets with a glass of water, either without food or with a low-fat meal. Avoid taking them with high-fat meals, or take them at least 1 hour before or 2 hours after such a meal.
Important
The maximum daily dose is 800 mg, which is 4 tablets per day.
Possible Side Effects
COMMON
- •Diarrhea
- •Nausea (feeling sick)
- •Feeling weak or tired (fatigue)
- •Pain (including mouth pain, stomach pain, headache, bone pain, tumor pain)
- •Hair loss (alopecia)
- •Hot or painful hands or feet (hand-foot skin reaction)
- •Itching or rash
- •Vomiting
- •Bleeding (including in the brain, bowel wall, and airways)
- •High blood pressure or increase in blood pressure (hypertension)
- •Infections
- •Loss of appetite (anorexia)
- •Constipation
- •Joint pain (arthralgia)
- •Fever
- •Weight loss
- •Dry skin
RARE
- •Allergic reaction with swelling of the skin (e.g., face, tongue) that may cause difficulty breathing or swallowing (angioedema)
- •Abnormal heart rhythm (QT prolongation)
- •Liver inflammation which can lead to nausea, vomiting, stomach pain, and yellow skin (drug-induced hepatitis)
- •Sunburn-like rash that may appear on skin previously exposed to radiation therapy and can become severe ("radiation recall" dermatitis)
- •Severe skin and/or mucous membrane reactions that may involve painful blisters and fever, as well as skin shedding (Stevens-Johnson syndrome and toxic epidermal necrolysis)
- •Abnormal muscle breakdown that can lead to kidney problems (rhabdomyolysis)
- •Kidney damage that leads to large amounts of protein leaking into the urine (nephrotic syndrome)
- •Inflammation of blood vessels in the skin, which can cause a rash (leukocytoclastic vasculitis)
- •Flu-like symptoms
- •Indigestion (dyspepsia)
- •Difficulty swallowing (dysphagia)
- •Inflamed or dry mouth, tongue pain (stomatitis and mucositis)
- •Low calcium levels in the blood (hypocalcemia)
- •Low potassium levels in the blood (hypokalemia)
- •Low blood sugar levels (hypoglycemia)
- •Muscle pain (myalgia)
- •Altered sensation in fingers and toes, including tingling and numbness (peripheral sensory neuropathy)
- •Depression
- •Erection problems (impotence)
- •Voice changes (dysphonia)
- •Acne
- •Inflamed, dry, or peeling skin (dermatitis, skin desquamation)
- •Heart failure
- •Heart attack (myocardial infarction) or chest pain
- •Ringing in the ears (tinnitus)
- •Kidney failure
- •Abnormally high levels of protein in urine (proteinuria)
- •General weakness or lack of strength (asthenia)
- •Decreased number of white blood cells (leukopenia and neutropenia)
- •Decreased number of red blood cells (anemia)
- •Decreased number of platelets (thrombocytopenia)
- •Inflammation of hair follicles (folliculitis)
- •Underactive thyroid gland (hypothyroidism)
- •Low sodium levels in the blood (hyponatremia)
- •Taste disturbance (dysgeusia)
- •Redness of the face and often other body parts (flushing)
- •Runny nose (rhinorrhea)
- •Heartburn (gastroesophageal reflux)
- •Skin cancer (keratoacanthoma or squamous cell carcinoma)
- •Thickening of the outermost skin layer (hyperkeratosis)
- •Sudden, involuntary muscle contractions (muscle spasms)
- •Inflamed stomach lining (gastritis)
- •Stomach pain caused by inflammation of the pancreas, gallbladder, and/or bile ducts
- •Yellow skin or eyes (jaundice) caused by high bile pigment levels in the blood (hyperbilirubinemia)
- •Allergy-like reactions (including skin reactions and hives)
- •Dehydration
- •Enlarged breasts (gynecomastia)
- •Breathing difficulties (lung disease)
- •Eczema
- •Overactive thyroid gland (hyperthyroidism)
- •Rash with blisters (erythema multiforme)
- •Abnormally high blood pressure
- •Holes in the bowel wall (gastrointestinal perforation)
- •Temporary swelling of the back of the brain, which can cause headaches, altered consciousness, seizures, and vision changes, including blindness (reversible posterior leukoencephalopathy, RPLE)
- •Sudden, severe allergic reaction (anaphylactic reaction)
- •Impaired brain function, which may include drowsiness, behavioral changes, or confusion (encephalopathy)
- •Enlargement and weakening of a blood vessel wall or a rupture in a blood vessel wall (aneurysms and arterial dissections)
- •Nausea, shortness of breath, irregular heartbeat, muscle cramps, seizures, cloudy urine, and tiredness (tumor lysis syndrome, TLS)
Important Warnings
- If you experience skin problems, such as rash or changes on your hands and feet, your doctor may need to adjust your treatment.
- Sorafenib STADA can increase blood pressure, so your doctor will monitor it and may prescribe medication if needed.
- Tell your doctor if you have or have had an aneurysm (a bulging and weak spot in a blood vessel) or a ruptured blood vessel.
- If you have diabetes, your blood sugar levels will be checked regularly to adjust medication doses if necessary.
- Treatment with Sorafenib STADA can increase the risk of bleeding. Be especially careful if you are taking blood thinners like warfarin.
Show 11 more warnings
- If you experience chest pain or heart problems, your doctor may temporarily stop or end your treatment.
- Inform your doctor if you have a heart rhythm disorder, such as a prolonged QT interval.
- If you are having or recently had surgery, Sorafenib STADA treatment may be paused as it can affect wound healing.
- Using Sorafenib STADA with certain other cancer drugs (like irinotecan or docetaxel) may increase their side effects.
- Some antibiotics (like neomycin) can reduce the effect of Sorafenib STADA.
- If you have severe liver problems, you might experience more intense side effects.
- If you have kidney problems, your doctor will monitor your fluid and electrolyte balance.
- Sorafenib STADA may reduce fertility in both men and women. Discuss any concerns with your doctor.
- Holes in the bowel wall can occur during treatment. If this happens, your doctor will stop the treatment.
- If you have thyroid cancer, your doctor will check your calcium and thyroid hormone levels.
- Seek immediate medical attention if you experience nausea, shortness of breath, irregular heartbeat, muscle cramps, seizures, cloudy urine, and tiredness, as these could be life-threatening symptoms of tumor lysis syndrome (TLS).