Sitagliptin/Metformin Sandoz
This medicine helps adults with type 2 diabetes manage blood sugar by increasing insulin and reducing sugar production in the body.
Form
tabletti, kalvopäällysteinen
Strength
50 mg / 850 mg
Active Ingredient
Metformin hydrochloride
Manufacturer
Sandoz A/S
How to Use
Dosage
Take one tablet twice daily.
Method
Take orally with meals to reduce stomach upset.
Important
Your doctor will determine your maximum daily dose.
Possible Side Effects
COMMON
- •Low blood sugar
- •Nausea
- •Vomiting
- •Diarrhea
- •Stomach pain
- •Flatulence (gas)
- •Constipation
- •Loss of appetite
- •Headache
- •Upper respiratory infection (like a common cold)
- •Stuffy or runny nose and sore throat
- •Joint pain (osteoarthritis)
- •Pain in arms or legs
- •Swelling of hands or legs
- •Metallic taste in mouth
- •Low vitamin B12 levels (can cause fatigue, sore tongue, tingling, pale skin)
RARE
- •Drowsiness
- •Dry mouth
- •Dizziness
- •Itching
- •Decreased number of platelets (which help blood clot)
- •Kidney problems (sometimes requiring dialysis)
- •Joint pain
- •Muscle pain
- •Back pain
- •Lung disease (Interstitial lung disease)
- •Bullous pemphigoid (a type of skin blistering)
- •Hepatitis (liver inflammation)
- •Hives
- •Skin redness or rash
Important Warnings
- Do not take if you are allergic to sitagliptin, metformin, or any other ingredient in this medicine.
- Do not take if you have severe kidney problems.
- Do not take if your diabetes is poorly controlled, with very high blood sugar, nausea, vomiting, diarrhea, fast weight loss, lactic acidosis, or ketoacidosis (too many acid substances in your blood).
- Do not take if you have a severe infection or are very dehydrated.
- If you are having an X-ray or scan with contrast dye, you must stop this medicine for a short time before and after the procedure, as instructed by your doctor.
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- Do not take if you recently had a heart attack or have severe blood circulation problems like shock or breathing difficulties.
- Do not take if you have liver disease.
- Do not take if you drink a lot of alcohol regularly or occasionally.
- Do not take if you are breastfeeding.
- This medicine may cause inflammation of the pancreas (pancreatitis), which is a serious condition. Seek medical help immediately if you have severe stomach pain.
- If you get skin blisters, tell your doctor, as this could be a sign of a serious skin condition.
- Lactic acidosis is a very rare but serious side effect. Stop taking this medicine and get medical help right away if you have symptoms like vomiting, stomach pain, muscle cramps, feeling very tired, trouble breathing, or a slow heartbeat.
- Do not take if you have type 1 diabetes.
- If you take sulfonylurea or insulin with this medicine, your blood sugar might drop too low. Your doctor may need to adjust your dose.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Reduce the dose already in mild renal impairment. Do not use in severe renal impairment or tissue hypoxia. May reduce the absorption of vitamin B12. Consider risk of lactic acidosis. The drug should be paused during fever, gastroenteritis or dehydration, and before surgery or imaging with a contrast agent. (updated 20.5.2024)