Sitagliptin/Metformin ratiopharm
This medicine helps control blood sugar levels in adults with type 2 diabetes by increasing insulin after meals and reducing the amount of sugar the body produces.
Form
tabletti, kalvopäällysteinen
Strength
50 mg / 850 mg
Active Ingredient
Metformin hydrochloride
Manufacturer
ratiopharm GmbH
How to Use
Dosage
One tablet
Method
Take orally twice a day with meals to reduce stomach upset.
Important
Your doctor will adjust your dose if needed; typically two tablets per day.
Possible Side Effects
COMMON
- •Low blood sugar
- •Nausea
- •Vomiting
- •Diarrhea
- •Abdominal pain (stomach ache)
- •Flatulence (gas)
- •Constipation
- •Headache
- •Upper respiratory tract infection (e.g., common cold)
- •Stuffy or runny nose and sore throat
- •Loss of appetite
- •Metallic taste in mouth
- •Arm or leg pain
- •Swelling of hands or feet
RARE
- •Drowsiness
- •Dry mouth
- •Itching
- •Decreased platelet count (may cause easy bruising or bleeding)
- •Kidney problems (sometimes needing dialysis)
- •Joint pain
- •Muscle pain
- •Back pain
- •Interstitial lung disease (a serious lung condition)
- •Hives
- •Skin redness (rash)
- •Hepatitis (liver inflammation)
- •Low vitamin B12 levels (symptoms: extreme tiredness, sore/red tongue, tingling, pale/yellow skin)
Important Warnings
- Do not take if you are allergic to sitagliptin, metformin, or any other ingredient in this medicine.
- Do not take if you have severe kidney problems, a severe infection, or are very dehydrated.
- Stop taking this medicine and call your doctor right away if you have severe stomach pain (which could be pancreatitis) or symptoms of lactic acidosis (like feeling very tired, having trouble breathing, muscle cramps, feeling cold, stomach pain, or vomiting). Lactic acidosis is a serious medical emergency.
- You may need to stop taking this medicine before and after certain X-ray procedures involving contrast dye, as advised by your doctor.
- Do not take if you have recently had a heart attack, or have severe circulation or breathing problems.
Show 4 more warnings
- Do not take if you have severe liver disease or drink a lot of alcohol.
- Do not take if you are pregnant or breastfeeding.
- Tell your doctor if you develop skin blisters.
- This medicine can cause low blood sugar, dizziness, or drowsiness, especially with other diabetes medications, which may affect your ability to drive or use machines.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Reduce the dose already in mild renal impairment. Do not use in severe renal impairment or tissue hypoxia. May reduce the absorption of vitamin B12. Consider risk of lactic acidosis. The drug should be paused during fever, gastroenteritis or dehydration, and before surgery or imaging with a contrast agent. (updated 20.5.2024)