Sitagliptin/Metformin Grindeks
This medicine helps adults with type 2 diabetes manage their blood sugar by increasing insulin after meals and reducing the amount of sugar produced by the body.
Form
tabletti, kalvopäällysteinen
Strength
50 mg / 1000 mg
Active Ingredient
Sitagliptin hydrochloride monohydrate
Manufacturer
Grindeks AS
How to Use
Dosage
Take one tablet two times a day.
Method
Swallow the tablet whole with a meal to reduce the risk of stomach upset.
Important
Your doctor will determine your maximum daily dose based on your condition and kidney function.
Possible Side Effects
COMMON
- •low blood sugar
- •nausea
- •vomiting
- •flatulence
- •diarrhea
- •constipation
- •abdominal pain
- •loss of appetite
- •headache
- •upper respiratory infection
- •stuffy or runny nose and sore throat
- •osteoarthritis
- •pain in arms or legs
- •metallic taste in mouth
- •decreased or low vitamin B12 levels in the blood
- •swelling of hands or feet
RARE
- •drowsiness
- •dry mouth
- •dizziness
- •itching
- •decreased platelet count
- •kidney problems (sometimes requiring dialysis)
- •joint pain (general)
- •muscle pain
- •back pain
- •interstitial lung disease
- •bullous pemphigoid (a type of skin blisters)
- •hepatitis (liver inflammation)
- •hives
- •skin redness / rash
Important Warnings
- Do not take this medicine if you are allergic to sitagliptin, metformin, or any other ingredients.
- Do not take this medicine if you have severe kidney failure.
- Do not take this medicine if you have uncontrolled diabetes with high blood sugar, nausea, vomiting, diarrhea, rapid weight loss, lactic acidosis, or ketoacidosis.
- Do not take this medicine if you have a severe infection or are dehydrated.
- You must stop taking this medicine before and for two or more days after an X-ray where a contrast agent is injected, as directed by your doctor.
Show 7 more warnings
- Do not take this medicine if you recently had a heart attack or have severe circulatory or breathing problems, such as shock.
- Do not take this medicine if you have liver disease.
- Do not take this medicine if you drink a lot of alcohol (either daily or occasionally).
- Do not take this medicine if you are breastfeeding.
- STOP taking this medicine and contact a doctor immediately if you have severe and constant stomach pain (in the abdomen) that may spread to your back, with or without nausea and vomiting. These can be signs of pancreatitis (inflammation of the pancreas).
- If you notice blisters on your skin, tell your doctor. Your doctor may ask you to stop taking this medicine.
- STOP taking this medicine and contact a doctor or nearest hospital immediately if you have symptoms of lactic acidosis, such as vomiting, stomach pain, muscle cramps, a general feeling of not being well and severe tiredness, difficulty breathing, decreased body temperature, and slow pulse. Lactic acidosis can lead to coma.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Reduce the dose already in mild renal impairment. Do not use in severe renal impairment or tissue hypoxia. May reduce the absorption of vitamin B12. Consider risk of lactic acidosis. The drug should be paused during fever, gastroenteritis or dehydration, and before surgery or imaging with a contrast agent. (updated 20.5.2024)