Sitagliptin/Metformin Grindeks
This medicine helps adults with type 2 diabetes control their blood sugar by increasing insulin after meals and reducing sugar made by the body.
Form
tabletti, kalvopäällysteinen
Strength
50 mg / 850 mg
Active Ingredient
Sitagliptin hydrochloride monohydrate
Manufacturer
Grindeks AS
How to Use
Dosage
Take one tablet twice a day.
Method
Take with meals to reduce the risk of stomach upset.
Important
Do not exceed the dose prescribed by your doctor, usually one tablet twice daily.
Possible Side Effects
COMMON
- •low blood sugar
- •nausea
- •vomiting
- •diarrhea
- •stomach pain
- •flatulence
- •constipation
- •loss of appetite
- •headache
- •upper respiratory infection (stuffy or runny nose and sore throat)
- •joint pain, arm or leg pain
- •swelling of hands or legs
- •metallic taste in mouth
- •low vitamin B12 levels in blood (may cause extreme tiredness, sore or red tongue, tingling sensation, pale or yellowish skin)
RARE
- •drowsiness
- •dizziness
- •itching
- •dry mouth
- •reduced number of platelets
- •kidney problems (sometimes requiring dialysis)
- •muscle pain
- •back pain
- •interstitial lung disease
- •skin blisters (bullous pemphigoid)
- •liver inflammation (hepatitis)
- •hives
- •skin redness or rash
Important Warnings
- Stop taking this medicine and contact a doctor or nearest hospital immediately if you experience symptoms of lactic acidosis (e.g., vomiting, stomach pain, muscle cramps, severe tiredness, difficulty breathing, feeling cold).
- Stop taking this medicine and contact a doctor immediately if you have severe, ongoing stomach pain with or without nausea and vomiting. These could be signs of pancreatitis (inflammation of the pancreas).
- Stop taking this medicine and contact a doctor immediately if you have a severe allergic reaction, such as rash, hives, skin blisters, swelling of the face/lips/tongue/throat, which may cause difficulty breathing or swallowing.
- Do not take if you have severe kidney problems.
- Do not take if your diabetes is not well-controlled (e.g., high blood sugar, nausea, vomiting, diarrhea, rapid weight loss, ketoacidosis).
Show 3 more warnings
- Do not take if you have a severe infection, are dehydrated, recently had a heart attack, severe circulation problems, liver disease, or if you drink a lot of alcohol.
- Do not use this medicine if you are pregnant or breastfeeding.
- This medicine should be stopped before or during imaging procedures that use iodine contrast.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Reduce the dose already in mild renal impairment. Do not use in severe renal impairment or tissue hypoxia. May reduce the absorption of vitamin B12. Consider risk of lactic acidosis. The drug should be paused during fever, gastroenteritis or dehydration, and before surgery or imaging with a contrast agent. (updated 20.5.2024)