Sitagliptin/Metformin Glenmark
Sitagliptin/Metformin Glenmark helps lower blood sugar and manage type 2 diabetes by increasing insulin after meals and reducing sugar production by the body.
Form
tabletti, kalvopäällysteinen
Strength
50 mg / 1000 mg
Active Ingredient
Sitagliptin hydrochloride monohydrate
Manufacturer
Glenmark Arzneimittel GmbH
How to Use
Dosage
Take one tablet twice a day.
Method
Take with meals to help prevent stomach upset.
Important
Your doctor will decide your maximum daily dose and may adjust it, especially if you have kidney problems.
Possible Side Effects
COMMON
- •Low blood sugar
- •Nausea
- •Vomiting
- •Diarrhea
- •Bloating or gas
- •Constipation
- •Stomach pain
- •Headache
- •Upper respiratory infection
- •Stuffy or runny nose and sore throat
- •Osteoarthritis
- •Arm or leg pain
- •Loss of appetite (especially when starting metformin)
- •Metallic taste in mouth
- •Decreased vitamin B12 levels in blood (may cause extreme tiredness, sore tongue, tingling, pale or yellow skin)
RARE
- •Drowsiness
- •Dizziness
- •Itching
- •Dry mouth
- •Decreased number of platelets (blood cells that help blood clot)
- •Kidney problems (sometimes requiring dialysis)
- •Joint pain
- •Muscle pain
- •Back pain
- •Interstitial lung disease (a type of lung disease)
- •Bullous pemphigoid (a skin blistering condition)
- •Hepatitis (liver inflammation)
- •Hives
- •Skin redness or rash
- •Swollen hands and legs (when taken with pioglitazone)
Important Warnings
- Do not take this medicine if you are allergic to sitagliptin, metformin, or any other ingredient in this medicine.
- Do not take this medicine if you have severe kidney problems.
- Stop taking this medicine and see your doctor immediately if you experience severe stomach pain that may spread to your back, with or without nausea and vomiting, as these can be signs of pancreatitis (inflammation of the pancreas).
- Stop taking this medicine and go to the nearest hospital immediately if you have symptoms of lactic acidosis, such as vomiting, stomach pain, muscle cramps, feeling unwell and tired, difficulty breathing, decreased body temperature, and slow heart rate. This is a very serious but rare side effect.
- If you get a severe allergic reaction, such as a rash, hives, skin blisters, or swelling of your face, lips, tongue, or throat causing breathing or swallowing problems, stop taking this medicine and contact your doctor right away.
Show 11 more warnings
- If you develop skin blisters, which could be a sign of a condition called bullous pemphigoid, your doctor may ask you to stop this medicine.
- Temporarily stop taking this medicine if you have severe dehydration (significant fluid loss) due to severe vomiting, diarrhea, fever, heat exposure, or drinking less than usual. Ask your doctor for advice.
- Do not take this medicine if you have uncontrolled diabetes with very high blood sugar, nausea, vomiting, diarrhea, rapid weight loss, or if you have lactic acidosis or ketoacidosis.
- Do not take this medicine if you have a severe infection or are very dehydrated.
- If you are having an imaging test that uses an iodine injection, you must stop taking this medicine before and for at least two days after the test, as directed by your doctor.
- Do not take this medicine if you have recently had a heart attack or have severe circulation problems, such as shock or trouble breathing.
- Do not take this medicine if you have liver problems.
- Do not take this medicine if you drink a lot of alcohol regularly or occasionally.
- Do not take this medicine if you are breastfeeding.
- Your doctor will check your kidney function at least once a year, or more often if you are older or have worsening kidney function.
- Avoid drinking too much alcohol while taking this medicine, as it can increase the risk of lactic acidosis.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Reduce the dose already in mild renal impairment. Do not use in severe renal impairment or tissue hypoxia. May reduce the absorption of vitamin B12. Consider risk of lactic acidosis. The drug should be paused during fever, gastroenteritis or dehydration, and before surgery or imaging with a contrast agent. (updated 20.5.2024)