Sislaf
Sislaf is a medicine that helps prevent blood clots from forming by blocking a substance called Factor Xa, which is needed for blood to clot.
How to Use
Dosage
Your doctor will tell you the exact dose. Typically, it's one 2.5 mg or 5 mg tablet twice a day, in the morning and evening, depending on your condition.
Method
Swallow the tablet whole with water. You can take it with or without food. If you have trouble swallowing, you can crush the tablet and mix it with water, 5% glucose solution, apple juice, or applesauce right before taking it. Try to take your tablets at the same time each day.
The maximum daily dose is 20 mg for the first 7 days when treating existing blood clots; otherwise, it is typically 5 mg or 10 mg as prescribed by your doctor.
Possible Side Effects
- •Anemia (may cause tiredness or paleness)
- •Bleeding (general, bruising, swelling, nosebleeds, bleeding gums, blood in urine, bleeding in stomach, intestines, rectum, eyes, or mouth, vaginal bleeding)
- •Nausea
- •Low blood pressure (may cause faintness or faster heartbeat)
- •Decreased platelet count (may affect blood clotting)
- •Rash
- •Increased gamma-glutamyl transferase (GGT) and/or alanine aminotransferase (ALAT) levels in blood tests
- •Bleeding after surgery, including blood or fluid leaking from surgical wound/incision or injection site
- •Bleeding in stomach or intestines with bright red blood in stools
- •Abnormal liver function, increased liver enzyme levels, increased bilirubin (may cause yellowing of skin or eyes)
- •Itching
- •Hair loss
- •Allergic reactions (may cause swelling of face, lips, mouth, tongue, throat, and difficulty breathing). Seek immediate medical attention if these symptoms occur.
- •Bleeding in muscle
- •Bleeding in the brain or spinal cord
- •Bleeding in the lungs or throat
- •Bleeding in the abdominal cavity or behind it
- •Rash with blisters that look like small targets (erythema multiforme)
- •Blood vessel inflammation (vasculitis) which may cause a rash or raised, flat, red, round spots under the skin or bruises.
Important Warnings
- Do not take Sislaf if you are allergic to apixaban or any other ingredients in this medicine.
- Do not take Sislaf if you are currently bleeding heavily.
- Do not take Sislaf if you have a condition that increases your risk of severe bleeding, such as a recent stomach ulcer, intestinal ulcer, or bleeding in the brain.
- Do not take Sislaf if you have liver disease that increases your risk of bleeding.
- Do not take Sislaf if you are already taking other medicines to prevent blood clots (like warfarin, rivaroxaban, dabigatran, or heparin), unless your doctor tells you to switch medicines, or if you are receiving heparin through a catheter to keep it open, or if you are having a procedure for an irregular heartbeat.
Show 13 more warnings
- Tell your doctor if you have bleeding problems, especially if your platelets don't work well.
- Tell your doctor if you have very high blood pressure that is not controlled by medicine.
- Tell your doctor if you are over 75 years old.
- Tell your doctor if you weigh 60 kg or less.
- Tell your doctor if you have severe kidney disease or are on dialysis.
- Tell your doctor if you have or have had liver problems; special care is needed if liver function changes.
- Tell your doctor if you have had a spinal catheter inserted or an injection in your spine (for anesthesia or pain relief); your doctor will tell you when to take this medicine after the catheter is removed.
- Tell your doctor if you have a prosthetic heart valve.
- Tell your doctor if your blood pressure is unstable, or if you are planning to have treatment or surgery to remove a blood clot from your lungs.
- Tell your doctor if you have antiphospholipid syndrome (an immune system disorder that increases the risk of blood clots), as another treatment might be better for you.
- If you need surgery or a procedure that might cause bleeding, your doctor might ask you to temporarily stop taking this medicine. Ask your doctor if you are unsure whether a procedure could cause bleeding.
- Do not take this medicine if you are pregnant. Contact your doctor immediately if you become pregnant while using this medicine.
- It is not known if Sislaf passes into breast milk. Ask your doctor or pharmacist for advice before taking this medicine if you are breastfeeding. They will advise you whether to stop breastfeeding or stop/not start this medicine.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Consider renal impairment, age and body weight when determining the dosage. Consider potential interactions especially with other drugs that increase the risk of bleeding. (updated 19.9.2025)