Sendoxan
Sendoxan is a cancer medicine that damages the DNA of cells, stopping them from dividing and killing them, and also weakens the immune system.
Form
tabletti, päällystetty
Strength
50 mg
Active Ingredient
Cyclophosphamide monohydrate
Manufacturer
Baxter Oy
How to Use
Dosage
The usual dose for adults is 2-4 tablets daily.
Method
Swallow the tablets whole. Your doctor will determine your exact dose individually.
Important
The maximum dose for adults is 4 tablets daily.
Possible Side Effects
COMMON
- •Bone marrow depression, low white blood cell count
- •Weakened immune response
- •Nausea, vomiting
- •Hair loss
- •Bladder inflammation, small amounts of blood in urine
- •Fever
- •Infections
- •Fever due to a lack of white blood cells
- •Bladder inflammation with bleeding, large amounts of blood in urine
- •Chills, weakness, fatigue, general malaise
RARE
- •Serious infections, such as blood poisoning or severe bacterial infection (septic shock)
- •Changes in blood counts (low platelets and red blood cells), leukemia or a rare blood disease (myelodysplastic syndrome), blood clotting disorders
- •Allergic and hypersensitivity reactions, including allergic shock
- •Dehydration, fluid buildup in the body, low blood sodium, or a rare blood and kidney disorder (hemolytic uremic syndrome)
- •Dizziness, confusion, seizures, nerve damage, changes in sensation and taste, headache, or multi-organ failure
- •Blurred vision, eye inflammation or swelling, deafness
- •Serious heart problems, such as fast or slow heartbeat, heart muscle disease, heart failure, heart attack or cardiac arrest, chest pain
- •High or low blood pressure
- •Severe breathing problems (ARDS), lung scarring, fluid in the lungs, cough, or other lung issues, high blood pressure in the lungs
- •Loss of appetite, weight gain, intestinal bleeding or inflammation, pancreatitis, mouth ulcers
- •Liver problems, such as liver vein blockage, hepatitis, enlarged liver, jaundice, fluid in the abdomen, or brain disease due to liver issues
- •Severe skin and mucous membrane reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis), skin discoloration, itching, rash
- •Muscle breakdown (rhabdomyolysis), muscle cramps, joint pain
- •Urinary tract bleeding, bladder swelling, inflammation or hardening, kidney problems or failure, high creatinine levels
- •Reduced sperm production, ovulation disorders, missed periods, or permanent infertility
- •Secondary tumors in the urinary tract and bladder
Important Warnings
- If you have ever had an allergic reaction to cyclophosphamide.
- If your bone marrow is not working correctly (this will be checked with blood tests).
- If you have bladder inflammation causing pain when you urinate.
- If you have an acute infection.
- If you have a blockage in your lower urinary tract and have difficulty urinating.
Show 15 more warnings
- If you are breastfeeding.
- If you are pregnant.
- Talk to your doctor if you have had or recently had radiation therapy or chemotherapy.
- If you have diabetes.
- If you have liver problems.
- If you have kidney problems. Your doctor will take blood tests to check how well your kidneys are working.
- If you have heart problems or have received radiation therapy to the heart area.
- If your general health is poor and you are weak.
- If you are elderly.
- Do not eat grapefruit or drink grapefruit juice while taking Sendoxan, as it can weaken the medicine's effect.
- Drinking alcohol can increase the risk of nausea and vomiting.
- Men and women should use effective contraception and avoid pregnancy for 6–12 months after treatment ends.
- Talk to your doctor about freezing sperm or eggs before starting treatment.
- If you notice blood in your urine, tell your doctor immediately.
- You are more likely to get infections when your blood cell count is low. Try to avoid close contact with people who have coughs, colds, or other infections.