Sacubitril/Valsartan Krka
Sacubitril/Valsartan Krka is a heart medicine used to treat a specific type of long-term heart failure in adults and children aged one year and older.
Form
tabletti, kalvopäällysteinen
Strength
97 mg / 103 mg
Active Ingredient
Sacubitril sodium
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
The usual starting dose is one 24 mg/26 mg or 49 mg/51 mg tablet twice a day (one in the morning and one in the evening); the usual target dose is 97 mg/103 mg twice a day.
Method
Swallow the tablet whole with a glass of water, with or without food. Do not split or crush the tablets.
Important
The maximum daily dose is 194 mg/206 mg, taken as 97 mg/103 mg twice a day.
Possible Side Effects
COMMON
- •Low blood pressure (hypotension), which can cause dizziness and light-headedness.
- •High potassium levels in the blood, seen in blood tests (hyperkalemia).
- •Decreased kidney function (renal impairment).
- •Cough
- •Light-headedness
- •Diarrhea
- •Low red blood cell count (anemia)
- •Tiredness (fatigue)
- •Acute kidney failure
- •Low potassium levels in the blood (hypokalemia)
- •Headache
- •Fainting (syncope)
- •Weakness (asthenia)
- •Nausea
- •Low blood pressure when standing up from sitting or lying down (orthostatic hypotension)
- •Gastritis (stomach pain, nausea)
- •Feeling dizzy (vertigo)
- •Low blood sugar (hypoglycemia)
RARE
- •Allergic reaction with rash and itching (hypersensitivity)
- •Dizziness when changing position from sitting to standing (postural dizziness)
- •Low sodium levels in the blood, seen in blood tests (hyponatremia)
- •Seeing, hearing, or feeling things that are not there (hallucinations)
- •Changes in sleep patterns (sleep disturbances)
- •Paranoia
- •Intestinal angioedema: swelling in the intestines with symptoms like abdominal pain, nausea, vomiting, and diarrhea.
- •Sudden involuntary muscle jerks (myoclonus)
Important Warnings
- Do not take if you are allergic to sacubitril, valsartan, or any other ingredient in this medicine.
- Do not take if you are using an ACE inhibitor; wait 36 hours after the last dose of an ACE inhibitor before starting this medicine.
- Stop taking this medicine and seek immediate medical help if you experience swelling of the face, lips, tongue, or throat, which may cause difficulty breathing or swallowing (angioedema).
- Do not take if you have a history of hereditary angioedema or angioedema with an unknown cause.
- Do not take if you have diabetes or kidney problems and are taking a blood pressure-lowering medicine containing aliskiren.
Show 2 more warnings
- Do not take if you have severe liver disease.
- Do not take if you are more than 3 months pregnant, as it can cause serious harm to your baby.