Sacubitril/Valsartan Krka
Sacubitril/Valsartan Krka is a heart medicine used to treat a certain type of long-term heart failure in adults and children aged one year and older.
Form
tabletti, kalvopäällysteinen
Strength
24 mg / 26 mg
Active Ingredient
Sacubitril sodium
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
The usual starting dose is one 24 mg/26 mg or 49 mg/51 mg tablet twice a day (morning and evening); the usual target dose is one 97 mg/103 mg tablet twice a day.
Method
Swallow the tablets whole with a glass of water. You can take them with or without food. Do not break or crush the tablets.
Important
The usual maximum recommended daily dose is one 97 mg/103 mg tablet twice a day.
Possible Side Effects
COMMON
- •Low blood pressure (hypotension), which can cause dizziness and light-headedness.
- •High potassium in the blood (hyperkalemia), seen in blood tests.
- •Reduced kidney function (renal impairment).
- •Cough.
- •Light-headedness.
- •Diarrhea.
- •Low red blood cell count (anemia), seen in blood tests.
- •Tiredness (fatigue).
- •Sudden inability of kidneys to work properly (acute kidney failure).
- •Low potassium in the blood (hypokalemia), seen in blood tests.
- •Headache.
- •Fainting (syncope).
- •Weakness (asthenia).
- •Nausea.
- •Low blood pressure (dizziness, light-headedness) when changing from sitting or lying to standing.
- •Stomach inflammation (stomach pain, nausea).
- •Spinning sensation (vertigo/dizziness).
- •Low blood sugar (hypoglycemia), seen in blood tests.
RARE
- •Angioedema (swelling of the face, lips, tongue, and throat that can cause difficulty breathing or swallowing).
- •Allergic reaction with rash and itching (hypersensitivity).
- •Dizziness when changing from sitting to standing (postural dizziness).
- •Low sodium in the blood (hyponatremia), seen in blood tests.
- •Seeing, hearing, or feeling things that are not there (hallucinations).
- •Changes in sleep patterns (sleep disorders).
- •Paranoia.
- •Intestinal angioedema: swelling in the intestines with symptoms like stomach pain, nausea, vomiting, and diarrhea.
- •Sudden involuntary muscle twitching (myoclonus).
Important Warnings
- Do not take this medicine if you are allergic to sacubitril, valsartan, or any other ingredients of this medicine.
- Do not use this medicine if you are also taking an ACE inhibitor; wait 36 hours after your last ACE inhibitor dose before starting Sacubitril/Valsartan Krka.
- Do not use if you have had angioedema (rapid swelling of the face, throat, or other body parts) which can make breathing or swallowing difficult.
- Do not use if you have diabetes or kidney disease and are taking a blood pressure medicine containing aliskiren.
- Do not use if you have severe liver disease.
Show 4 more warnings
- Do not use if you are more than 3 months pregnant or are in the first 3 months of pregnancy; tell your doctor right away if you become pregnant.
- Do not give this medicine to children under 1 year of age.
- If you feel dizzy or very tired while taking this medicine, do not drive, cycle, or use machinery.
- Do not stop taking this medicine suddenly without your doctor's approval, as it may worsen your condition.