Riociguat Adalvo
Riociguat Adalvo widens the blood vessels leading from the heart to the lungs and is used to treat pulmonary hypertension, improving physical performance.
Form
tabletti, kalvopäällysteinen
Strength
1.5 mg
Active Ingredient
Riociguat
Manufacturer
Adalvo Limited
How to Use
Dosage
The recommended starting dose is one 1 mg tablet 3 times a day for 2 weeks.
Method
Take tablets three times a day, every 6–8 hours, with or without food. They can be crushed and mixed with water or soft food.
Important
Your doctor may gradually increase the dose up to a maximum of 2.5 mg 3 times a day, making the maximum daily dose 7.5 mg.
Possible Side Effects
COMMON
- •Coughing up blood (hemoptysis)
- •Headache
- •Dizziness
- •Indigestion (dyspepsia)
- •Swelling of arms and legs (peripheral edema)
- •Diarrhea
- •Nausea or vomiting
- •Inflammation of the stomach (gastritis)
- •Inflammation of the digestive tract (gastroenteritis)
- •Decrease in red blood cells (anemia), showing as pale skin, weakness, or shortness of breath
- •Irregular, strong, or fast heartbeat (palpitations)
- •Low blood pressure (hypotension)
- •Nosebleed (epistaxis)
- •Difficulty breathing through the nose (nasal congestion)
- •Stomach, intestinal, or abdominal pain
- •Heartburn (reflux disease)
- •Difficulty swallowing (dysphagia)
- •Constipation
- •Abdominal swelling
RARE
- •Sudden bleeding in the lungs (pulmonary hemorrhage)
Important Warnings
- Do not take this medicine if you are allergic to riociguat or any other of its ingredients.
- Do not take if you are already using medicines called PDE5 inhibitors (like sildenafil).
- Do not take if you have severe liver disease.
- Do not take if you are pregnant.
- Do not take if you are using medicines called nitrates or nitric oxide donors.
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- Do not take if you are using other similar medicines that stimulate soluble guanylate cyclase (like vericiguat).
- Do not take if you have very low blood pressure.
- Do not take if you have high blood pressure in your lungs due to unknown reasons, with lung scarring.
- Tell your doctor if you have recently had serious bleeding in your lungs.
- Tell your doctor if you have been treated for coughing up blood.
- Tell your doctor if you are taking blood thinning medicines, as this medicine can increase bleeding risk.
- Tell your doctor if you feel very short of breath.
- Tell your doctor if you have symptoms of low blood pressure like dizziness or fainting.
- Tell your doctor if you are taking medicines for fungal infections (e.g., ketoconazole) or HIV infection (e.g., ritonavir), as your dose may need to be adjusted.
- Tell your doctor if you are on dialysis or your kidneys do not work well, as this medicine is not recommended.
- Tell your doctor if you have moderate liver problems.
- Tell your doctor if you start or stop smoking during treatment, as your dose may need to be changed.
- Women who can get pregnant must use effective birth control during this treatment.