Remodulin
Remodulin helps lower high blood pressure in the lungs, making it easier for the heart to pump blood and improving your breathing and ability to be active.
How to Use
Dosage
Your doctor will determine your exact dose and how fast it should be given, which can be adjusted over time under medical supervision.
Method
Remodulin is given as a continuous infusion through a small tube (cannula) placed under your skin (usually in your stomach or thigh) or directly into a vein (usually in your neck, chest, or groin), using a portable pump. In some cases, an implanted pump under the skin can be used for intravenous infusion.
Your doctor will adjust your dose to find what works best for you, ensuring it is effective without causing too many side effects. Do not increase the dose without consulting your doctor.
Possible Side Effects
- •Widened blood vessels and skin redness
- •Pain or tenderness around the infusion site
- •Skin discoloration or bruising around the infusion site
- •Headaches
- •Rash
- •Nausea (feeling sick)
- •Diarrhea
- •Jaw pain
- •Dizziness
- •Vomiting
- •Fainting or feeling lightheaded due to low blood pressure
- •Itching or general skin redness
- •Swelling of feet, ankles, legs, or general fluid retention
- •Bleeding such as nosebleeds, coughing up blood, blood in urine, bleeding gums, or blood in stool
- •Joint pain
- •Muscle pain
- •Pain in legs and/or arms
- •Infusion site infection
- •Infusion site abscess
- •Reduced platelet count (thrombocytopenia), which can affect blood clotting
- •Bleeding at the infusion site
- •Bone pain
- •Rash with skin discoloration or hives
- •Infection of the tissue under the skin (cellulitis)
- •Shortness of breath, fatigue, swelling in legs and abdomen, and persistent cough due to the heart pumping too much blood (fluid overload)
- •Inflammation of a vein (thrombophlebitis)
- •Bacterial infection in the bloodstream (bacteremia)
- •Severe bloodstream bacterial infection (sepsis), which can be life-threatening
Important Warnings
- Do not use Remodulin if you are allergic to treprostinil or any other ingredients in this medicine.
- Do not use if you have a serious lung condition called pulmonary veno-occlusive disease (PVOD).
- Do not use if you have severe liver disease.
- Do not use if you have certain heart problems, such as a heart attack in the last 6 months, severe irregular heartbeat, serious coronary artery disease, heart valve problems, or untreated heart disease.
- Do not use if you have a high risk of bleeding, for example, from an active stomach ulcer or another bleeding condition.
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- Do not use if you have had a stroke or other brain circulation problem in the last 3 months.
- Tell your doctor before starting treatment if you have any other liver disease, are very overweight (BMI over 30 kg/m²), are HIV-positive, have high blood pressure in your liver veins, or have a congenital heart defect.
- During treatment, tell your doctor if your blood pressure drops too low.
- During treatment, contact your doctor immediately if you have quickly worsening breathing problems or a persistent cough, as this could be a sign of too much fluid in your lungs, asthma, or another condition.
- During treatment, tell your doctor if you experience severe bleeding, as Remodulin can increase the risk of bleeding by slowing down blood clotting.
- During intravenous treatment, tell your doctor if you develop a fever or if the infusion site becomes red, swollen, or tender to the touch, as these could be signs of an infection.