Quetiapine Accord
Quetiapine Accord helps treat mental health conditions like schizophrenia, mania, and depression related to bipolar disorder.
Form
depottabletti
Strength
150 mg
Active Ingredient
Quetiapine fumarate
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
Your doctor will tell you how much to take; the usual daily amount is between 150 mg and 800 mg.
Method
Take the tablets once a day, whole with water, at least one hour before food or at bedtime, as your doctor advises. Do not break, chew, or crush them.
Important
The most you should take in a day is usually 800 mg.
Possible Side Effects
COMMON
- •Feeling dizzy (which can cause falls), headache, or having a dry mouth.
- •Feeling sleepy (this might get better over time, but can lead to falls).
- •Symptoms when stopping treatment, like trouble sleeping, feeling sick, headache, diarrhea, vomiting, dizziness, and feeling irritable.
- •Gaining weight.
- •Unusual muscle movements, like difficulty starting to move, shaking, restlessness, or stiff muscles without pain.
- •Changes in the levels of certain fats in your blood (triglycerides and total cholesterol).
- •Fast heart rate.
- •Feeling your heart pound, race, or skip beats.
- •Constipation or stomach problems.
- •Feeling weak.
- •Swelling in your arms or legs.
- •Low blood pressure when standing up, which can make you dizzy or faint (leading to falls).
- •High blood sugar levels.
- •Blurred eyesight.
- •Strange dreams or nightmares.
- •Increased hunger.
- •Feeling irritable.
- •Problems with speaking.
- •Feeling short of breath.
- •Vomiting (mostly in older people).
- •Fever.
- •Changes in thyroid hormone levels in the blood.
- •A decrease in certain types of white blood cells.
- •Increased liver enzymes in blood tests.
- •Increased prolactin hormone levels in the blood (can cause breast swelling and unexpected milk in both men and women, and missed or irregular periods in women).
RARE
- •Seizures or fits.
- •Allergic reactions, like hives and swelling around the mouth or face.
- •An uncomfortable feeling in your legs (restless legs syndrome).
- •Trouble swallowing.
- •Uncontrolled movements, especially of the face or tongue.
- •Problems with sexual function.
- •Diabetes.
- •Changes in the heart's electrical activity seen on an ECG (prolonged QT interval).
- •Slower heartbeat than normal, especially at the start of treatment, which may involve low blood pressure and fainting.
- •Problems with urinating.
- •Fainting (which can lead to falls).
- •Stuffy nose.
- •A decrease in red blood cells.
- •Low sodium levels in the blood.
- •Worsening of diabetes.
- •Feeling confused.
- •A combination of symptoms like high fever, sweating, stiff muscles, extreme drowsiness, or weakness (Neuroleptic Malignant Syndrome).
- •Yellow skin and eyes (jaundice) or liver inflammation (hepatitis).
- •A long-lasting and painful erection.
- •Breast swelling and unexpected milk production (galactorrhea), or menstrual problems.
- •Blood clots in veins (especially in legs, causing swelling, pain, redness), which can travel to the lungs, causing chest pain and breathing problems.
- •Sleepwalking, sleep-talking, sleep-eating, or other activities while asleep.
- •Drop in body temperature (hypothermia).
- •Inflammation of the pancreas.
- •Metabolic syndrome (a mix of at least three of: belly fat, low 'good' cholesterol, high triglycerides, high blood pressure, and high blood sugar).
- •Agranulocytosis (fever, flu-like symptoms, sore throat, or other infection with very low white blood cell count).
- •Blockage in the bowel.
- •Increased levels of creatine phosphokinase (a substance from muscles) in the blood.
- •Severe skin reactions such as widespread rash with blisters, peeling skin, or red patches (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, AGEP, erythema multiforme).
- •A very serious allergic reaction (anaphylactic shock) that can cause breathing problems or shock.
- •Sudden swelling of the skin, usually around the eyes, lips, or throat (angioedema).
- •Abnormal release of a hormone that controls urine volume.
- •Muscle fiber breakdown and muscle pain (rhabdomyolysis).
- •Withdrawal symptoms in newborns if the mother used Quetiapine Accord during pregnancy.
- •Stroke.
- •Heart muscle disease (cardiomyopathy).
- •Inflammation of the heart muscle (myocarditis).
- •Inflammation of blood vessels (vasculitis), often with small red or purple rashes.
Important Warnings
- Do not take this medicine if you are allergic to quetiapine or any other ingredients in it.
- Do not use with certain HIV medicines, antifungal medicines (like azoles), erythromycin or clarithromycin (for infections), or nefazodone (for depression).
- Get help right away if you have a fever, very stiff muscles, sweat a lot, or feel confused and less aware (signs of a serious condition called neuroleptic malignant syndrome).
- Tell your doctor immediately if you have movements you cannot control, especially in your face or tongue.
- Contact your doctor if you feel very dizzy or sleepy, as this can increase the risk of falls, especially for older people.
Show 10 more warnings
- Inform your doctor if you have seizures (fits).
- Tell your doctor if you have a long-lasting and painful erection.
- If you think about hurting yourself or suicide, contact your doctor or go to the nearest hospital right away.
- Stop taking this medicine and call your doctor right away if you get severe skin reactions like a widespread rash with blisters, peeling skin, or flu-like symptoms with rash and fever.
- Your weight should be checked regularly, as people taking this medicine have gained weight.
- This medicine is not for children or teenagers under 18 years old.
- Do not drink grapefruit juice while taking this medicine, as it can change how the medicine works.
- Be careful with alcohol, as it can make you feel more sleepy when taken with this medicine.
- Do not take if you are pregnant or breastfeeding unless your doctor says it is okay.
- This medicine can make you sleepy; do not drive or use machines until you know how it affects you.
Use in Elderly Patients
Category D
Avoid use in older adults. Anticholinergic. Sedative. For treatment of psychosis only. Inappropriate as a hypnotic. Increases the risk of cardiovascular events, QT prolongation and orthostatic hypotension. Increases risk of falls, extrapyramidal symptoms and cognitive impairment. Reduces the effectiveness of drugs for Alzheimer’s disease. Avoid grapefruit. (updated 15.1.2024)