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Quetiapine Accord

This medicine helps treat mental illnesses like schizophrenia (hearing or seeing things that aren't real), mania (feeling extremely excited or irritable), and bipolar depression (feeling very sad or low on energy).

Form
tabletti, kalvopäällysteinen
Strength
200 mg
Active Ingredient
Quetiapine hemifumarate
Manufacturer
Accord Healthcare B.V.

How to Use

Dosage

Your doctor will tell you how much to take. The usual daily dose is between 150 mg and 800 mg.

Method

Take the tablets once a day at bedtime or twice a day. Swallow whole with water, with or without food. Do not drink grapefruit juice.

Important

The maximum daily dose is 800 mg.

Possible Side Effects

COMMON
  • •Dizziness (which can lead to falls), headache, dry mouth.
  • •Feeling sleepy (this may lessen over time).
  • •Withdrawal symptoms if you stop the medicine suddenly, such as trouble sleeping, nausea, headache, diarrhea, vomiting, dizziness, and feeling irritable. (Gradual stopping is recommended).
  • •Weight gain.
  • •Abnormal muscle movements, such as difficulty starting movements, shaking, restlessness, or muscle stiffness without pain.
  • •Changes in certain fat levels in your blood (triglycerides and total cholesterol).
  • •Rapid heartbeat or a feeling of a pounding or irregular heart.
  • •Constipation, upset stomach (digestion problems).
  • •Weakness, swelling in arms or legs.
  • •Low blood pressure, especially when standing up, which can make you feel dizzy or faint (can lead to falls).
  • •High blood sugar, blurred vision.
  • •Abnormal dreams and nightmares, increased feeling of hunger.
  • •Irritability, speech and language problems.
  • •Suicidal thoughts and worsening depression.
  • •Shortness of breath, vomiting (mostly in older people).
  • •Fever, changes in thyroid hormone levels in the blood.
  • •Decrease in certain types of white blood cells, increase in liver enzymes measured in blood.
  • •Increased prolactin hormone levels in the blood, which can rarely cause breast swelling and unexpected milk production in men and women, or missed/irregular periods in women.
RARE
  • •Seizures or fits.
  • •Allergic reactions, such as hives or swelling of the skin and around the mouth.
  • •Fainting (which can lead to falls).
  • •Unpleasant feeling in the legs (restless legs syndrome).
  • •Difficulty swallowing.
  • •Uncontrolled movements, especially of the face or tongue.
  • •Sexual dysfunction.
  • •Stuffy nose.
  • •Diabetes.
  • •Changes in the heart's electrical activity seen on an ECG (prolonged QT interval).
  • •Abnormally slow heart rate, which can happen at the start of treatment and may be linked to low blood pressure and fainting.
  • •Difficulty urinating.
  • •Reduced number of red blood cells.
  • •Reduced sodium levels in the blood.
  • •Worsening of existing diabetes.
  • •Confusion.
  • •A serious condition called neuroleptic malignant syndrome (high fever, sweating, severe muscle stiffness, significant drowsiness or weakness).
  • •Yellowing of the skin and eyes (jaundice).
  • •Liver inflammation (hepatitis).
  • •Long-lasting and painful erection (priapism).
  • •Menstrual disorders.
  • •Blood clots in veins, especially in the legs (symptoms include swelling, pain, and redness in the leg), which can travel to the lungs, causing chest pain and breathing difficulties.
  • •Sleepwalking, talking in sleep, eating in sleep, or other activities during sleep.
  • •Low body temperature (hypothermia).
  • •Breast swelling and unexpected milk production (galactorrhea).
  • •Inflammation of the pancreas (pancreatitis).
  • •Metabolic syndrome (a combination of at least three signs: increased belly fat, low "good" cholesterol, increased triglycerides, high blood pressure, and high blood sugar).
  • •A serious condition with fever, flu-like symptoms, sore throat, or another infection combined with very low white blood cell count (agranulocytosis).
  • •Bowel obstruction.
  • •Increased levels of creatine phosphokinase (a substance from muscles) in the blood.
  • •Severe rash, blisters, or red patches on the skin.
  • •Severe allergic reaction (anaphylactic shock), which can cause breathing difficulties or shock.
  • •Rapid swelling of the skin, usually around the eyes, lips, or throat (angioedema).
  • •A severe condition with blistering skin in the mouth, on the skin, eyes, and genitals (Stevens-Johnson syndrome).
  • •Abnormal secretion of a hormone that controls urine volume.
  • •Muscle breakdown and muscle pain (rhabdomyolysis).
  • •Rash with irregular red patches (erythema multiforme).
  • •Sudden red skin areas with small pus-filled blisters (acute generalized exanthematous pustulosis - AGEP).
  • •Severe, sudden allergic reaction with symptoms like fever, skin blisters, and skin peeling (toxic epidermal necrolysis - TEN).
  • •Drug reaction with eosinophilia and systemic symptoms (DRESS), which appears as flu-like symptoms along with rash, high fever, swollen lymph nodes, and abnormal blood counts (including high white blood cells and liver enzymes).
  • •Withdrawal symptoms in newborns if the mother used Quetiapine Accord during late pregnancy.
  • •Stroke.
  • •Heart muscle disease (cardiomyopathy).
  • •Inflammation of the heart muscle (myocarditis).
  • •Inflammation in blood vessels (vasculitis), often with a rash of small red or purple bumps.

Important Warnings

  • Do not take if you are allergic to quetiapine or any other ingredients in this medicine.
  • Do not take with certain medicines for HIV, fungal infections (azoles), infections (erythromycin or clarithromycin), or depression (nefazodone).
  • Tell your doctor immediately if you get a high fever, very stiff muscles, sweating, or feel very sleepy or confused.
  • Tell your doctor immediately if you have uncontrolled movements, especially of your face or tongue.
  • Tell your doctor immediately if you feel dizzy or very sleepy, as this may increase the risk of falls, especially in older people.
Show 10 more warnings
  • Tell your doctor immediately if you have seizures (fits).
  • Tell your doctor immediately if you have a long-lasting and painful erection.
  • Tell your doctor immediately if you have a fast or irregular heartbeat, even at rest, palpitations, breathing problems, chest pain, or unexplained tiredness. Your heart needs to be checked right away.
  • Tell your doctor as soon as possible if you have a fever, flu-like symptoms, sore throat, or any other infection, as this could mean you have very few white blood cells.
  • Tell your doctor as soon as possible if you have constipation with long-lasting stomach pain, or constipation that treatment doesn't help, as this could lead to a severe bowel blockage.
  • If you are depressed, you might sometimes think about hurting yourself or taking your own life. If you have these thoughts, contact your doctor or hospital immediately.
  • If you notice any severe skin reactions, such as widespread rash with blisters and peeling skin (especially around the mouth, nose, eyes, and genitals), widespread skin peeling, flu-like symptoms with rash, fever, swollen lymph nodes, small pus-filled blisters, or red itchy patches, stop taking Quetiapine Accord and contact your doctor or hospital immediately.
  • Do not use this medicine if you are pregnant or breastfeeding. Discuss with your doctor first if you are pregnant or planning to become pregnant.
  • This medicine can make you sleepy. Do not drive or use machines until you know how it affects you.
  • This medicine should not be used in children and adolescents under 18 years.

Additional Information

ATC Code: N05AH04
→ View Professional Information (PDF)→ View Patient Leaflet (PDF)