Quetiapin Krka
Quetiapine is a medicine used to treat several mental health conditions, such as bipolar disorder and schizophrenia, helping to balance mood and thoughts.
Form
depottabletti
Strength
300 mg
Active Ingredient
Quetiapine hemifumarate
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
Your doctor will determine your starting dose; the daily dose usually ranges from 150 mg to 800 mg, depending on your specific condition.
Method
Take the tablets once a day whole with water; do not split, chew, or crush them. Take them without food, at least 1 hour before a meal or at bedtime, and avoid grapefruit juice.
Important
The usual maximum daily dose is 800 mg, but your doctor will set the exact dose for you.
Possible Side Effects
COMMON
- •Dizziness (can sometimes lead to falls)
- •Headache
- •Dry mouth
- •Drowsiness (may lessen over time, can sometimes lead to falls)
- •Withdrawal symptoms if you stop suddenly, like trouble sleeping, nausea, headache, diarrhea, vomiting, dizziness, and feeling irritable. It's best to stop gradually over 1-2 weeks as advised by your doctor.
- •Weight gain
- •Abnormal muscle movements, such as difficulty starting movements, shaking, restlessness, or muscle stiffness without pain
- •Changes in certain fat levels in your blood (triglycerides and total cholesterol)
- •Fast heart rate
- •Feeling your heart pound, race, or skip beats (palpitations)
- •Constipation, upset stomach (indigestion)
- •Weakness or lack of energy
- •Swelling in arms or legs
- •Low blood pressure, especially when standing up (may cause dizziness or faintness, leading to falls)
- •High blood sugar
- •Blurred vision
- •Abnormal dreams and nightmares
- •Increased appetite
- •Feeling irritable
- •Speech and language problems
- •Thoughts of harming yourself or worsening depression
- •Shortness of breath
- •Vomiting (mainly in older people)
- •Fever
- •Changes in thyroid hormone levels in your blood
- •Decrease in certain types of white blood cells
- •Increase in liver enzymes (substances from your liver) measured in blood tests
- •Increased prolactin hormone levels in your blood, which can rarely cause breast swelling in men and women, unexpected breast milk production, or missed or irregular periods in women.
RARE
- •Seizures
- •Allergic reactions, such as hives (itchy red welts) or swelling of the skin and around the mouth
- •Unpleasant feeling in the legs (restless legs syndrome)
- •Difficulty swallowing
- •Uncontrolled movements, especially of the face or tongue
- •Sexual problems
- •Diabetes or worsening of existing diabetes
- •Changes in your heart's electrical activity seen on an ECG (QT prolongation)
- •Slower heart rate than normal (may happen at the start of treatment and be linked to low blood pressure and fainting)
- •Difficulty urinating
- •Fainting (can lead to falls)
- •Blocked nose
- •Decrease in red blood cells
- •Decrease in blood sodium levels
- •Confusion
- •A serious condition with fever, sweating, severe muscle stiffness, feeling very sleepy, or fainting (called neuroleptic malignant syndrome)
- •Yellow skin and eyes (jaundice), or liver inflammation (hepatitis)
- •Long-lasting and painful erection (priapism)
- •Breast swelling and unexpected milk production (galactorrhea), or menstrual problems
- •Blood clots in the veins, especially in the legs (with swelling, pain, and redness), which can travel to the lungs, causing chest pain and breathing difficulties. Seek immediate medical help if this happens.
- •Sleepwalking, sleep-talking, sleep-eating, or other activities while asleep
- •Drop in body temperature (hypothermia)
- •Inflammation of the pancreas (pancreatitis)
- •Metabolic syndrome (a combination of at least three conditions: increased belly fat, lower 'good' cholesterol, increased blood fats called triglycerides, high blood pressure, and high blood sugar)
- •Very low white blood cell count (agranulocytosis), with symptoms like fever, flu-like symptoms, and sore throat
- •Bowel blockage
- •Increased levels of creatine phosphokinase (a substance from muscles) in your blood
- •Severe skin reactions, such as a widespread rash with blisters, peeling skin, or red, itchy patches, sometimes with flu-like symptoms.
- •Severe allergic reaction (anaphylactic shock) that can cause breathing problems or shock
- •Rapid swelling of the skin, usually around the eyes, lips, or throat (angioedema)
- •Abnormal release of a hormone that controls how much urine you make
- •Muscle fiber breakdown and muscle pain (rhabdomyolysis)
- •Stroke
- •Heart muscle disease (cardiomyopathy)
- •Inflammation of the heart muscle (myocarditis)
- •Inflammation of blood vessels (vasculitis), often with small red or purple spots on the skin.
Important Warnings
- Do not take if you are allergic to quetiapine or any other ingredients in this medicine.
- Avoid use with certain HIV medications, antifungal drugs, antibiotics (like erythromycin, clarithromycin), and nefazodone (an antidepressant).
- Seek immediate medical help if you experience a combination of fever and muscle stiffness, uncontrollable movements (especially of the face or tongue), seizures, a long-lasting and painful erection, or a fast/irregular heartbeat.
- Tell your doctor as soon as possible if you have fever, flu-like symptoms, sore throat, or other infections, as this could indicate a very low white blood cell count.
- Inform your doctor if you have constipation and stomach pain that doesn't get better, as it could lead to a serious bowel blockage.
Show 6 more warnings
- If you have depression and thoughts of harming yourself or suicide, contact your doctor immediately, especially if you stop the medicine suddenly, as such thoughts can increase.
- If you notice severe skin reactions like a widespread rash with blisters, peeling skin, or red, itchy patches, stop the medicine and seek immediate medical help.
- Weight gain is possible with this medicine, so your weight should be checked regularly by you and your doctor.
- This medicine is not for use in children or adolescents under 18 years of age.
- Talk to your doctor before use if you are pregnant, breastfeeding, or planning to become pregnant, as this medicine should not be used during pregnancy or breastfeeding unless specifically discussed with your doctor.
- This medicine may cause drowsiness. Do not drive or operate machinery until you know how it affects you and you feel alert.