Propolipid
Propolipid is a general anesthetic used to put patients to sleep for surgery or other medical procedures, or to calm them down without fully sleeping.
Form
injektio-/infuusioneste, emulsio, esitäytetty ruisku
Strength
20 mg/ml
Active Ingredient
Propofol
Manufacturer
Fresenius Kabi AB
How to Use
Dosage
The dose is adjusted by a doctor based on your age, weight, and condition, typically 1.5-2.5 mg per kg to start anesthesia, or 0.3-12 mg per kg per hour for continuous sedation or anesthesia.
Method
This medicine is given as an injection or infusion into a vein, usually in the back of your hand or arm, by a doctor or nurse.
Important
For continuous sedation, the infusion rate should not exceed 4.0 mg of propofol per kg of body weight per hour.
Possible Side Effects
COMMON
- •Pain at injection site (before falling asleep)
- •Slow or fast heartbeat
- •Low blood pressure
- •Changes in breathing (fast breathing, stopped breathing)
- •Hiccups
- •Cough (may also occur upon waking)
- •Headache
- •Nausea, vomiting
RARE
- •Swelling and redness or blood clots in the vein near the injection site
- •Body twitching and trembling or seizures (may also occur upon waking)
- •Severe allergic reaction (difficulty breathing, skin swelling/redness, hot flashes)
- •Fluid in the lungs causing shortness of breath (may also occur upon waking)
- •Unusual urine color (may also occur upon waking)
- •Involuntary movements
- •Severe skin and tissue reaction if medicine is accidentally given outside the vein
- •Prolonged, often painful erection
- •Dizziness, chills and feeling cold (after anesthesia)
- •Agitation (after anesthesia)
- •Unconsciousness after the procedure (patient recovered without problems)
- •Pancreatitis (severe stomach pain, link not proven)
- •Fever after surgery
- •Abnormal good mood (euphoria)
- •Sexual arousal
- •Irregular heartbeat
- •ECG changes (Brugada syndrome-like ECG)
- •Liver enlargement
- •Kidney failure
- •Muscle breakdown (rhabdomyolysis), increased blood acidity, increased blood potassium and fat levels, heart failure
- •Drug abuse (mainly among healthcare professionals)
- •Hepatitis (liver inflammation), acute liver failure (symptoms like yellow skin/eyes, itching, dark urine, stomach pain, tenderness in liver area, sometimes loss of appetite)
- •Drowsiness (when given with lidocaine)
- •Vomiting (when given with lidocaine)
- •Seizures (when given with lidocaine)
- •Slow heart rate (bradycardia) (when given with lidocaine)
- •Irregular heartbeat (arrhythmia) (when given with lidocaine)
- •Shock (when given with lidocaine)
Important Warnings
- Do not use if you are allergic to propofol, soy, peanuts, or any other ingredient in this medicine.
- Do not use for sedation in children under 16 years old in intensive care.
- Use with extreme caution if you have severe heart failure, another serious heart condition, or are receiving electroconvulsive therapy (ECT).
- Older or very weak patients should receive this medicine with caution and possibly lower doses.
- Tell your doctor if you have heart, lung, kidney, or liver disease, epilepsy, high pressure in your head, abnormal fat levels in your blood, or if you are dehydrated.
Show 5 more warnings
- Certain conditions like heart failure, circulatory problems, severe breathing difficulties, dehydration, or seizures must be treated before you receive Propolipid.
- Propolipid may increase the risk of seizures, slow heart rate, and blood flow problems to organs if you are overweight and receive high doses.
- Do not leave the hospital until you are fully awake, and if you go home soon after, make sure someone accompanies you. Do not drive or operate machinery until the medicine's effects have completely worn off.
- Not recommended during pregnancy unless absolutely necessary; breastfeeding mothers should stop breastfeeding and discard breast milk for 24 hours after treatment.
- This medicine contains soy oil; do not use if you are allergic to peanuts or soy.